ROBERTA RIBEIRO DE SANTIS SANTIAGO
Projetos de Pesquisa
Unidades Organizacionais
LIM/09 - Laboratório de Pneumologia, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
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conferenceObject SPONTANEOIJS EFFORT CAUSES OCCULT PENDELLUFT DURING MECHANICAL VENTILATION(2013) YOSHIDA, T.; TORSANI, V.; GOMES, S.; SANTIAGO, R. R. D. S.; BERALDO, M.; TUCCI, M. R.; ZIN, W. A.; KAVANAGH, B. P.; AMATO, M. B. P.conferenceObject Spontaneous Breathing During Mechanical Ventilation Causes Unsuspected Over-Inflation Of Dependent Lung(2013) YOSHIDA, T.; TORSANI, V.; GOMES, S.; SANTIAGO, R. R. S.; CARVALHO, C. R. R.; KAVANAGH, B. P.; AMATO, M. B. P.conferenceObject Follow-up of surviving acute respiratory distress syndrome patients using quantitative computed tomography(2013) TOUFEN JR., Carlos; SANTIAGO, Roberta; HIROTA, Adriana; AMATO, Marcelo; CARVALHO, Carlos- Spontaneous Effort Causes Occult Pendelluft during Mechanical Ventilation(2013) YOSHIDA, Takeshi; TORSANI, Vinicius; GOMES, Susimeire; SANTIS, Roberta R. De; BERALDO, Marcelo A.; COSTA, Eduardo L. V.; TUCCI, Mauro R.; ZIN, Walter A.; KAVANAGH, Brian P.; AMATO, Marcelo B. P.Rationale: In normal lungs, local changes in pleural pressure (P-pl) are generalized over the whole pleural surface. However, in a patient with injured lungs, we observed (using electrical impedance tomography) a pendelluft phenomenon (movement of air within the lung from nondependent to dependent regions without change in tidal volume) that was caused by spontaneous breathing during mechanical ventilation. Objectives: To test the hypotheses that in injured lungs negative P-pl generated by diaphragm contraction has localized effects (in dependent regions) that are not uniformly transmitted, and that such localized changes in P-pl cause pendelluft. Methods: We used electrical impedance tomography and dynamic computed tomography (CT) to analyze regional inflation in anesthetized pigs with lung injury. Changes in local P-pl were measured in nondependent versus dependent regions using intrabronchial balloon catheters. The airway pressure needed to achieve comparable dependent lung inflation during paralysis versus spontaneous breathing was estimated. Measurements and Main Results: In all animals, spontaneous breathing caused pendelluft during early inflation, which was associated with more negative local P-pl in dependent regions versus nondependent regions (-13.0 +/- 4.0 vs. -6.4 +/- 3.8 cm H2O; P < 0.05). Dynamic CT confirmed pendelluft, which occurred despite limitation of tidal volume to less than 6 ml/kg. Comparable inflation of dependent lung during paralysis required almost threefold greater driving pressure (and tidal volume) versus spontaneous breathing (28.0 +/- 0.5 vs. 10.3 +/- 0.6 cm H2O, P < 0.01; 14.8 +/- 4.6 vs. 5.8 +/- 1.6 ml/kg, P < 0.05). Conclusions: Spontaneous breathing effort during mechanical ventilation causes unsuspected overstretch of dependent lung during early inflation (associated with reciprocal deflation of nondependent lung). Even when not increasing tidal volume, strong spontaneous effort may potentially enhance lung damage.
conferenceObject IMPACT OF ABDOMINAL MASS LOADING ON LUNG COLLAPSE DETECTED BY EIT DURING PEEP TITRATION ON A PORCINE MODEL OF ACUTE LUNG INJURY(2013) TORSANI, V.; HUKRAUF, S.; RAU, A.; HAMMERMUELLER, S.; GOMES, S.; SANTIAGO, R. R. D. S.; COSTA, E. L. V.; RESKE, A. W.; AMATO, M. B. P.conferenceObject HIGHER PEEP LEVELS (13 VS 8 CM H2O) AFTER CARDIAC SURGERY CAN PREVENT PROGRESSIVE ATELECTASIS AND IMPAIRED LUNG FUNCTION DURING WEANING(2013) SANTIAGO, R. R. D. S.; LEME, A. C.; FREITAS, M. B. V.; FIGUEIREDO, P. L.; SOUZA, M. L. D. A.; GOMES, S.; HIROTA, A. S.; CARVALHO, C. R. R.; GALAS, F. R. G.; HAJAR, L. A.; TOLDO, K. F.; COSTA, E. Leite Vieira; AMATO, M. B. P.