FATIMA DAS DORES DA CRUZ
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
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- Left cardiac sympathetic denervation for treatment of symptomatic systolic heart failure patients: a pilot study(2012) CONCEICAO-SOUZA, Germano Emilio; PEGO-FERNANDES, Paulo Manuel; CRUZ, Fatima das Dores; GUIMARAES, Guilherme Veiga; BACAL, Fernando; VIEIRA, Marcelo Luiz Campos; GRUPI, Cesar Jose; GIORGI, Maria Clementina Pinto; CONSOLIM-COLOMBO, Fernanda Marciano; NEGRAO, Carlos Eduardo; RONDON, Maria Urbana P.; MOREIRA, Luiz Felipe Pinho; BOCCHI, Edimar AlcidesTo evaluate the feasibility, safety, and potential beneficial effects of left cardiac sympathetic denervation (LCSD) in systolic heart failure (HF) patients. In this prospective, randomized pilot study, inclusion criteria were New York Heart Association (NYHA) functional class II or III, left ventricular ejection fraction (LVEF) 40, sinus rhythm, and resting heart rate 65 b.p.m., despite optimal medical therapy (MT). Fifteen patients were randomly assigned either to MT alone or MT plus LCSD. The primary endpoint was safety, measured by mortality in the first month of follow-up and morbidity according to pre-specified criteria. Secondary endpoints were exercise capacity, quality of life, LVEF, muscle sympathetic nerve activity (MSNA), brain natriuretic peptide (BNP) levels and 24 h Holter mean heart rate before and after 6 months. We studied clinical effects in long-term follow-up. Ten patients underwent LCSD. There were no adverse events attributable to surgery. In the LCSD group, LVEF improved from 25 6.6 to 33 5.2 (P 0.03); 6 min walking distance improved from 167 35 to 198 47 m (P 0.02). Minnesota Living with Heart Failure Questionnaire (MLWHFQ) score physical dimension changed from 21 5 to 15 7 (P 0.06). The remaining analysed variables were unchanged. During 848 549 days of follow-up, in the MT group, three patients either died or underwent cardiac transplantation (CT), while in the LCSD group six were alive without CT. LCSD was feasible and seemed to be safe in systolic HF patients. Its beneficial effects warrant the development of a larger randomized trial. Trail registration: NCT01224899.
- Updating of the Brazilian guidelines for chronic heart failure - 2012(2012) BOCCHI, Edimar Alcides; MARCONDES-BRAGA, Fabiana Goulart; BACAL, Fernando; FERRAZ, Almir Sergio; ALBUQUERQUE, Denilson; RODRIGUES, Dirceu de Almeida; MESQUITA, Evandro Tinoco; VILAS-BOAS, Fabio; CRUZ, Fatima; RAMIRES, Felix; VILLACORTA JUNIOR, Humberto; SOUZA NETO, Joao David de; ROSSI NETO, Joao Manoel; MOURA, Lidia Zytynski; BECK-DA-SILVA, Luis; MOREIRA, Luiz Felipe; ROHDE, Luis Eduardo Paim; MONTERA, Marcelo Westerlund; SIMOES, Marcus Vinicius; MOREIRA, Maria da Consolacao; CLAUSELL, Nadine; BESTETTI, Reinaldo; MOURILHE-ROCHA, Ricardo; MANGINI, Sandrigo; RASSI, Salvador; AYUB-FERREIRA, Silvia Moreira; MARTINS, Silvia Marinho; BORDIGNON, Solange; ISSA, Victor Sarli
conferenceObject Left cardiac sympathetic denervation for treatment of symptomatic systolic heart failure patients-3 years follow-up(2012) CONCEICAO-SOUZA, G. E.; PEGO-FERNANDES, P. M.; MOREIRA, L. F. P.; CRUZ, F. D.; GUIMARAES, G. V.; BACAL, F.; VIEIRA, M. L. C.; CONSOLIM-COLOMBO, F. M.; NEGRAO, C. E.; BOCCHI, E. A.conferenceObject Components of life quality evaluation in heart failure clinic(2012) CRUZ, F. D. C.; ISSA, V. S.; AYUB, S. F.; BACAL, F.; BOCCHI, E. A.