FERNANDA DEGOBBI TENORIO QUIRINO DOS SANTOS LOPES

(Fonte: Lattes)
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LIM/20 - Laboratório de Terapêutica Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/05 - Laboratório de Poluição Atmosférica Experimental, Hospital das Clínicas, Faculdade de Medicina

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Agora exibindo 1 - 10 de 23
  • conferenceObject
    Reduction In Vacht Levels Induced Pulmonary Inflammation In Experimental Model Of Pulmonary Emphysema
    (2015) BANZATO, R.; PINHEIRO, N. M.; OLIVO, C.; RANCON, F.; LOPES, F.; CAPERUTO, L.; CAMARA, N.; MARTINS, M.; TIBERIO, I.; PRADO, M.; PRADO, V.; PRADO, C.
  • article 0 Citação(ões) na Scopus
    Smoking induces increased apoptosis in osteoblasts: changes in bone matrix organic components
    (2023) KOHLER, Julia Benini; SILVA, Alex Ferreira da; FARIAS, Walleson Alves; SAMPAIO, Barbara Fialho Carvalho; NEVES, Marco Aurelio Silveiro; LIMA, Leandro Gregorut; LOURENCO, Juliana Dias; MOREIRA, Alyne Riani; BARBOSA, Alexandre Povoa; TIBERIO, Iolanda de Fatima Lopes Calvo; TEODORO, Walcy Rosolia; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos
    Clinical studies demonstrate the impact of smoking on bone tissue fragility and higher incidence of fractures. However, it is not totally understood which physiological mechanisms could be involved in these events. Previously, we showed important changes in bone tissue components in experimental model of cigarette smoke (CS) exposure. CS exposure induces worsening in bone mineralization and a decrease in collagen type I deposition, leading to bone fragility. Considering that the majority of clinical studies described bone structural changes by radiographic images, in this study we performed analyses ""in situ"" using tissue samples from smokers, former smokers and non-smokers to better understand how the increase in inflammatory mediators induced by smoking exposure could interfere in bone cells activity leading bone structural changes. We observed increased levels of IL-1 beta, IL-6 and TNF-alpha in bone tissue homogenates with a concomitant increase in osteoblast apoptosis in smokers and former smokers compared with non-smokers. Histological changes in both smokers and former smokers were characterized by reduction in collagen type I. Only in smokers, it was observed decrease in trabecular area, suggesting increased bone resorption and increase in collagen type V. These results showed that osteoblasts apoptosis in association with increased bone resorption leads bone structural changes in smokers.
  • conferenceObject
    Green Areas and PM2,5 exposure could be associated with Asthma and COPD?
    (2023) ALMEIDA, Francine Maria; MOREIRA, Tiana Carla Lopes; OLIVEIRA, Lucas Miranda; RIGHETTI, Renato Fraga; LOPES, Fernanda Degobbi Tenorio Quirino Santos; ALENCAR, Airlane P.; GOUVEIA, Nelson; MAUAD, Thais; LOTUFO, Paulo A.; BENSENOR, Isabela; SANTOS, Itamar Souza; TIBERIO, Iolanda Fatima Lopes Calvo
  • conferenceObject
    Effects of anti-IL 17 on inflammation in Asthma, COPD and Asthma-COPD models
    (2022) ALMEIDA, F. M.; CAMARGO, L. N.; MARTINS, N.; LOURENCO, J. D.; BEZERRA, S. K. M.; SARAIVA-ROMANHOLO, B.; LEICK, E. A.; LOPES, F. D. Q. S.; PRADO, C. M.; RIGHETTI, R. F.; TIBERIO, I. F. L. C.
  • conferenceObject
    The Role of Alpha 7 Nicotinic Receptor on Lung Alterations in an Experimental Model of Emphysema Induced by Elastase
    (2019) BANZATO, R. S.; SANTANA, F. P. R.; OLIVO, C. R.; LOPES, F. D. Q. S.; TIBERIO, I. F. L. C.; PRADO, M. A. M.; PRADO, V. F.; PRADO, C. M.
  • conferenceObject
    The role of monoterpenes derived from essential oils in lung alteration in a model of emphysema
    (2016) PEREIRA, Ellen; GUERREIRO, Marina; SANTANA, Fernanda; PINHEIRO, Nathalia; CAPELLO, Tabata; LOPES, Fernanda; OLIVO, Clarice; TIBERIO, Iolanda; MARTINS, Milton; LAGO, Joao; PRADO, Carla
  • conferenceObject
    Effects of environmental exposure to iron powder in an elastase mice model
    (2022) GALLI, T. Tafarel; CAMPOS, E. C.; SANTOS, T. M.; FUKUZAKI, S.; CAMARGO, L. N.; BEZERRA, S. K. M.; HAMAGUCHI, S. S. S.; SILVA, F. J. A. Da; SARAIVA-ROMANHOLO, B. M.; OLIVO, C. R.; PRADO, C. M.; LOPES, F. Degobbi Tenorio Quirino Dos Santos; LEICK, E. A.; BOUROTTE, C. L. M.; BENSENOR, I. J. M.; LOTUFO, P. A.; RIGHETTI, R. F.; TIBERIO, I. F. L. C.
  • article 4 Citação(ões) na Scopus
    Editorial: The importance of Th17/Treg imbalance in asthma and COPD development and progression
    (2022) LOPES, Fernanda Degobbi T. Q. S.; TIBERIO, Iolanda de Fatima Lopes Calvo; LEME, Adriana; FAIRCLOUGH, Lucy
  • conferenceObject
    Autonomic modulation's recovery after acute smoking in adults
    (2014) XAVIER, Rafaella Fagundes; ITO, Juliana Tiyaki; RAMOS, Dionei; LIMA, Fabiano Francisco; MANZANO, Beatriz Martins; RODRIGUES, Fernanda Maria Machado; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos; VANDERLEI, Luiz Carlos Marques; RAMOS, Ercy Mara Cipulo
  • article 0 Citação(ões) na Scopus
    Investigating the Effects of a New Peptide, Derived from the Enterolobium contortisiliquum Proteinase Inhibitor (EcTI), on Inflammation, Remodeling, and Oxidative Stress in an Experimental Mouse Model of Asthma-Chronic Obstructive Pulmonary Disease Overlap (ACO)
    (2023) BARBOSA, Jessica Anastacia Silva; SILVA, Luana Laura Sales da; JOAO, Juliana Morelli Lopes Goncalves; CAMPOS, Elaine Cristina de; FUKUZAKI, Silvia; CAMARGO, Leandro do Nascimento; SANTOS, Tabata Maruyama dos; SANTOS, Henrique Tibucheski dos; BEZERRA, Suellen Karoline Moreira; SARAIVA-ROMANHOLO, Beatriz Mangueira; LOPES, Fernanda Degobbi Tenorio Quirino dos Santos; BONTURI, Camila Ramalho; OLIVA, Maria Luiza Vilela; LEICK, Edna Aparecida; RIGHETTI, Renato Fraga; TIBERIO, Iolanda de Fatima Lopes Calvo
    The synthesized peptide derived from Enterolobium contortisiliquum (pep3-EcTI) has been associated with potent anti-inflammatory and antioxidant effects, and it may be a potential new treatment for asthma-COPD overlap-ACO). Purpose: To investigate the primary sequence effects of pep3-EcTI in an experimental ACO. BALB/c mice were divided into eight groups: SAL (saline), OVA (ovalbumin), ELA (elastase), ACO (ovalbumin + elastase), ACO-pep3-EcTI (treated with inhibitor), ACO-DX (treated with dexamethasone), ACO-DX-pep3-EcTI (treated with dexamethasone and inhibitor), and SAL-pep3-EcTI (saline group treated with inhibitor). We evaluated the hyperresponsiveness to methacholine, exhaled nitric oxide, bronchoalveolar lavage fluid (BALF), mean linear intercept (Lm), inflammatory markers, tumor necrosis factor (TNF-alpha), interferon (IFN)), matrix metalloproteinases (MMPs), growth factor (TGF-beta), collagen fibers, the oxidative stress marker inducible nitric oxide synthase (iNOS), transcription factors, and the signaling pathway NF-kappa B in the airways (AW) and alveolar septa (AS). Statistical analysis was conducted using one-way ANOVA and t-tests, significant when p < 0.05. ACO caused alterations in the airways and alveolar septa. Compared with SAL, ACO-pep3-EcTI reversed the changes in the percentage of resistance of the respiratory system (%Rrs), the elastance of the respiratory system (%Ers), tissue resistance (%Gtis), tissue elastance (%Htis), airway resistance (%Raw), Lm, exhaled nitric oxide (ENO), lymphocytes, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, TNF-alpha, INF-gamma, MMP-12, transforming growth factor (TGF)-beta, collagen fibers, and iNOS. ACO-DX reversed the changes in %Rrs, %Ers, %Gtis, %Htis, %Raw, total cells, eosinophils, neutrophils, lymphocytes, macrophages, IL-1 beta, IL-6, IL-10, IL-13, IL-17, TNF-alpha, INF-gamma, MMP-12, TGF-beta, collagen fibers, and iNOS. ACO-DX-pep3-EcTI reversed the changes, as was also observed for the pep3-EcTI and the ACO-DX-pep3-EcTI. Significance: The pep3-EcTI was revealed to be a promising strategy for the treatment of ACO, asthma, and COPD.