MOACYR ROBERTO CUCE NOBRE
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/38 - Laboratório de Epidemiologia e Imunobiologia, Hospital das Clínicas, Faculdade de Medicina
LIM/38 - Laboratório de Epidemiologia e Imunobiologia, Hospital das Clínicas, Faculdade de Medicina
5 resultados
Resultados de Busca
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- Ice pack induced perineal analgesia after spontaneous vaginal birth: Randomized controlled trial(2018) FRANCISCO, Adriana Amorim; OLIVEIRA, Sonia Maria Junqueira Vasconcellos De; STEEN, Mary; NOBRE, Moacyr Roberto Cuce; SOUZA, Eder Viana DeBackground: Ice-pack is widely used for alleviating postpartum perineal pain sustained after birth related perineal trauma. However, it lacks robust evidence on timing and frequency of applications, to ensure the effective and safe use of this therapy. Aims: To evaluate if a 10 min ice-pack application relieved postpartum perineal pain and if the analgesic effect was maintained for up to 2 h. Methods: A randomised controlled trial conducted from December 2012 to February 2013 with 69 primiparous women >= 18 years old, 6-24 h postpartum, with perineal pain >= 3, who had not received anti-inflammatory medication or analgesics after childbirth, who were randomised to a single ice-pack application on the perineum for 10 min or standard care. The primary and secondary outcomes were a reduction >= 30% in perineal pain intensity, immediately after the application and the maintenance of the analgesic effect for up to 2 h, respectively. Findings: Immediately post-intervention, the proportion of women whose perineal pain decreased >= 30% was significantly higher in the experimental group. Within 2 h, there was no significant difference in the pain levels in both groups. Within 2 h, for 61.9% and 89.3% of women in the experimental and control group, respectively, the perineal pain levels remained unchanged. For the remaining participants, perineal pain was increasing after an average time of 1 h 45 min and 1 h 56 min for the experimental and control groups, respectively. Conclusion: By applying an ice-pack for 10 min to the perineum, effective pain relief is achieved, that is maintained for between 1 h 45 min and 2 h.
- Staying in the labor force among patients with rheumatoid arthritis and associated factors in Southern Brazil(2018) GOMES, Rafael Kmiliauskis Santos; SCHREINER, Luana Cristina; VIEIRA, Mateus Oliveira; MACHADO, Patricia Helena; NOBRE, Moacyr Roberto CuceBackground: Rheumatoid arthritis primarily affects the working-age population and may cause key functional and work limitations. As the disease progresses, individuals become increasingly unable to conduct daily activities, which has a substantial personal and socioeconomic impact. Fairly recent prior studies showed that patients with RA stop working 20 years earlier than age-matched controls. Factors related to sociodemographic, clinical, care and disease profiles might affect the loss of work capacity. The purpose of this study was to assess the factors associated with the prevalence of working patients with rheumatoid arthritis in the municipality of Blumenau. Methods: A cross-sectional, population-based study was conducted between July 2014 and January 2015, with 296 individuals aged 20 years or older, male and female, living in Blumenau, Santa Catarina state, Brazil, and diagnosed with rheumatoid arthritis according to the 1987 American College of Rheumatology criteria. The prevalence of working patients with RA was assessed by employment status self-reporting during the interview. The chi-squared test, Wald test and Poisson regression analysis were used to test the possible associations between the independent variables and outcome. Results: The prevalence of working patients with rheumatoid arthritis was 44.3%. Patients aged 20 to 59 years had a 90% higher prevalence of outcome than subjects aged 60 years or older. The prevalence of working patients was 132% and 73% higher among individuals with low income and high functional disability, measured using the Health Assessment Questionnaire (HAQ), respectively. Conclusion: The prevalence of working RA patients was highest among adult patients with low income and high functional disability. The first variable is directly related to the individual characteristic, the second reflects the socioeconomic context of the patient, and the third reflects the degree of disability caused by the disease, which may be modifiable by health professionals.
- Quality of life in patients with implantable cardioverter-defibrillator: systematic review of randomized controlled trials(2018) SILVA, Katia Regina da; COSTA, Roberto; RODRIGUES, Clarissa Garcia; SCHASECHTER, Andi; NOBRE, Moacyr Cuce; PASSMAN, Rod; MARK, Daniel B.Background: Implantable cardioverter-defibrillator (ICD) therapy significantly improves the survival of patients who are at high risk for sudden cardiac death. However, it is unclear whether this survival is accompanied by impairment on quality of life (QoL). Objectives: This systematic review sought to describe whether ICD therapy, as compared with standard treatment, can have an impact on QoL outcomes. Methods: Extensive literature searches were carried out in PubMed, EMBASE, LILACS and Cochrane Library. Eligible studies were randomized controlled trials (RCTs) of ICD versus medical therapy that reported valid and reliable measures of QoL. Included studies were reviewed to determine baseline patient characteristics, mean duration of follow-up, questionnaires used to assess QoL and association between QoL scores and ICD shock therapy. Results: Seven studies, enrolling a total of 5,701 patients, were included in this review. The analyzed trials showed conflicting results about the impact of ICD on QoL outcomes. Among the secondary prevention studies, CIDS reported a clear benefit from ICD and AVID showed no difference between ICD and amiodarone groups. Of the primary prevention trials, AMIOVIRT, MADIT II, DEFINITE, and SCD-HeFT found no evidence of impaired QoL in patients with an ICD. Evidence for an association between ICD shocks and QoL was mixed and seemed to depend on the interval between shocks and QoL assessment. Conclusion: There was no evidence of impaired QoL in patients with an ICD. However, ICD patients must be educated of all possible risks and benefits, including transitory declines in QoL after ICD shocks.
- SERIOUS ADVERSE REACTIONS REPORTED FOR DRUGS INVOLVED IN LAWSUITS FILED AGAINST THE BRAZILIAN PUBLIC HEALTH SYSTEM(2018) RIBEIRO, E.; RIBEIRO, A.; NOBRE, M. R.; SECOLI, S. R.
- DRUGS INVOLVED IN LAWSUITS FILED AGAINST THE UNIFIED HEALTH SYSTEM (SUS) IN SAO PAULO - BRAZIL, IN 2017(2018) RIBEIRO, A.; RIBEIRO, E.; NOBRE, M. R.; SECOLI, S. R.