DANIEL LUCAS DA CONCEICAO COSTA
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina
11 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 11
conferenceObject Fear Conditioning in Obsessive-compulsive Disorder Patients Treated with Sertraline: Preliminary Results(2015) DINIZ, Juliana B.; CAPPI, Carolina; COSTA, Daniel L. C.; REIMER, Adriano E.; OLIVEIRA, Amanda R. de; BRANDAO, Marcus L.; HOEXTER, Marcelo; MIGUEL, Euripedes C.; SHAVITT, Roseli G.conferenceObject Can early improvement be an indicator of treatment response at twelve weeks in obsessive-compulsive disorder? Implications for early-treatment decision-making(2013) COSTA, Daniel Lucas Conceicao; SHAVITT, Roseli Gedanke; CASSAB, Raony; JOAQUIM, Marines Alves; BORCATO, Sonia Regina; VALERIO, Carolina; MIGUEL, Euripedes Constantino; DINIZ, Juliana BeloconferenceObject Serotonin reuptake inhibitor augmentation with n-acetylcysteine in treatment resistant ocd: a double-blind randomized controlled trial(2015) COSTA, D. L. C.; DINIZ, J. B.; JOAQUIM, M.; ACCIARITO, A. C.; RODRIGUES, B.; ODA, E.; REQUENA, G.; MIGUEL, E. C.; SHAVITT, R. GedankeconferenceObject Fear conditioning and BDNF levels and genotype in obsessive-compulsive disorder patients pre and post treatment with sertraline: preliminary results(2015) DINIZ, J.; CAPPI, C.; COSTA, D.; REIMER, A.; OLIVEIRA, A. De; BRANDAO, M.; HOEXTER, M.; MIGUEL, E.; SHAVITT, R.conferenceObject Social Phobia in Obsessive-Compulsive Disorder: Prevalence and Correlates(2013) ASSUNCAO, M. C.; COSTA, D. C.; MATHIS, M. A.; SHAVITT, R. G.; FERRAO, Y. A.; ROSARIO, M. C.; MIGUEL, E. C.; TORRES, A. R.conferenceObject Can Early Improvement be an Indicator of Treatment Response at Twelve Weeks in Obsessive Compulsive Disorder? Implications for Early-Treatment Decision-Making(2012) COSTA, Daniel L. C.; DINIZ, Juliana B.; JOAQUIM, Marines; BORCATO, Sonia R.; VALERIO, Carolina; MIGUEL, Euripedes C.; SHAVITT, Roseli G.Background: Delayed onset of response to serotonin reuptake inhibitors represents a challenge in obsessive-compulsive disorder (OCD) treatment. In depression, absence of improvement in the first weeks has been raised as a motive to switch antidepressants before full non-response is observed. We aimed to investigate if early improvement is a predictor of OCD outcome after 12 weeks. Methods: Participants (n=150) were admitted to a specialized OCD outpatient program. Inclusion criteria: age 18-65, DSM-IV diagnosis of OCD, minimum baseline Yale-Brown Obsessive Compulsive Scale(Y-BOCS) score of 16, absence of previous pharmacological treatment for OCD. Fluoxetine was used up to 80mg/day. Systematic assessments were taken at baseline, weeks 4 and 12. Non-improvement at 4-weeks was defined as no reduction of baseline Y-BOCS scores. Response at 12 weeks was defined as 35% or greater decrease in baseline Y-BOC score. Spearman correlation, linear regression and chi-square test were performed to test the relationship between improvement at 4-weeks and the 12-weeks outcome. Results: Mean Y-BOCS scores(SD) at baseline, 4 and 12 weeks were, respectively: 27.3(5.4), 22.8(6.9) and 20.8(8.3). Correlation coefficient for 4-weeks improvement and 12-weeks outcome was 0.43(p=0.01). Linear regression analysis showed no-effect of the covariates on 12-weeks outcome and confirmed the relationship between improvement at 4-weeks and outcome at 12 weeks (β coef= 0.44, p< 0.01). Only five (11.9%) non-responders at 4-weeks were responders at 12-weeks (Pearson Chi-Square= 9.1, p= 0.003). Conclusions: Early improvement predicted 12-weeks outcome of OCD, which may have a role in early decision-making in OCD treatment.conferenceObject Fear of dying and fear of guilt: panic disorder/agoraphobia comorbidity in obsessive-compulsive disorder(2013) COSTA, D. L. C.; DINIZ, J. B.; FERRAO, Y. A.; ROSARIO-CAMPOS, M. C.; MIGUEL, E. C.; SHAVITT, R. G.; TORRES, A. R.; FONTENELLE, L. F.- Can early improvement be an indicator of treatment response at twelve weeks in obsessive-compulsive disorder?(2012) COSTA, D.; DINIZ, J. B.; JOAQUIM, M.; BORCATO, S.; VALERIO, C.; MIGUEL, E. C.; SHAVITT, R. G.
conferenceObject Efficacy and Safety of Transcranial Direct Current Stimulation as a Treatment for Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled Trial(2020) SILVA, Renata; BRUNONI, Andre R.; GOERIGK, Stephan; BATISTUZZO, Marcelo; COSTA, Daniel; DINIZ, Juliana; PADBERG, Frank; D'URSO, Giordano; MIGUEL, Euripedes; SHAVITT, RoseliconferenceObject Serotonin Reuptake Inhibitor Augmentation with N-Acetylcysteine in Treatment Resistant Obsessive-Compulsive Disorder: A Double-blind Randomized Controlled Trial(2015) COSTA, Daniel L. C.; DINIZ, Juliana B.; JOAQUIM, Marines; ACCIARITO, Ana C.; RODRIGUES, Bernardo; ODA, Eduardo F.; REQUENA, Guaraci; MIGUEL, Euripedes C.; PITTENGER, Christopher; BLOCH, Michael H.; SHAVITT, Roseli G.