BARBARA MARIA IANNI
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
LIM/11 - Laboratório de Cirurgia Cardiovascular e Fisiopatologia da Circulação, Hospital das Clínicas, Faculdade de Medicina
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
bookPart Miocardiopatia Chagásica(2016) HOTTA, Viviane Tiemi; LIMA, Marcio Silva Miguel; IANNI, Barbara Maria; MADY, Charles- Chagas' heart disease: gender differences in myocardial damage assessed by cardiovascular magnetic resonance(2016) ASSUNCAO JR., Antonildes N.; JEROSCH-HEROLD, Michael; MELO, Rodrigo L.; MAURICIO, Alejandra V.; ROCHA, Liliane; TORREAO, Jorge A.; FERNANDES, Fabio; IANNI, Barbara M.; MADY, Charles; KALIL-FILHO, Roberto; ROCHITTE, Carlos E.Background: Since a male-related higher cardiovascular morbidity and mortality in patients with Chagas' heart disease has been reported, we aimed to investigate gender differences in myocardial damage assessed by cardiovascular magnetic resonance (CMR). Methods and results: Retrospectively, 62 seropositive Chagas' heart disease patients referred to CMR (1.5 T) and with low probability of having significant coronary artery disease were included in this analysis. Amongst both sexes, there was a strong negative correlation between LV ejection fraction and myocardial fibrosis (male r = 0.64, female r = 0.73, both P < 0.001), with males showing significantly greater myocardial fibrosis (P = 0.002) and lower LV ejection fraction (P < 0.001) than females. After adjustment for potential confounders, gender remained associated with myocardial dysfunction, and 53% of the effect was mediated by myocardial fibrosis (P for mediation = 0.004). Also, the transmural pattern was more prevalent among male patients (23.7 vs. 9.9%, P < 0.001) as well as the myocardial heterogeneity or gray zone (2.2 vs. 1.3 g, P = 0.003). Conclusions: We observed gender-related differences in myocardial damage assessed by CMR in patients with Chagas' heart disease. As myocardial fibrosis and myocardial dysfunction are associated to cardiovascular outcomes, our findings might help to understand the poorer prognosis observed in males in Chagas' disease.
bookPart Doença de Chagas(2016) HOTTA, Viviane Tiemi; IANNI, Barbara MariabookPart Doenças do pericárdio(2016) FERNANDES, Fabio; IANNI, Barbara Maria; MESQUITA, Evandro TinococonferenceObject The predictive value of plasma Galectin-3 for cardiac impairment and mortality in patients with Chagas disease(2016) FERNANDES, F.; MOREIRA, C. H.; OLIVEIRA, L. C.; IANNI, B. M.; LORENZO, C. D.; RAMIRES, F. J. A.; NASTARI, L.; RIBEIRO, A. L. P.; CUNHA NETO, E.; SABINO, E. C.; MADY, C.conferenceObject Exercise Training Increases Baroreflex Control of Heart Rate and Decreases Muscle Sympathetic Nerve Activity in Chronic Chagasic Cardiomyopathy Patients(2016) SARMENTO, Adriana Oliveira; ANTUNES-CORREA, Ligia Moraes; LOBO, Denise Moreira Lima; CARVALHO, Bruna Elisa Piovezani; TROMBETTA, Ivani Credidio; ALVES, Maria Janieire Nazare Nunes; RONDON, Maria Urbana Pinto Brandao; RONDON, Eduardo; VIEIRA, Marcelo Luiz Campos; MADY, Charles; NEGRAO, Carlos Eduardo; IANNI, Barbara MariaconferenceObject Long-Term Prognostic Value of Myocardial Fibrosis in Chagas' Disease(2016) SENRA, Tiago; IANNI, Barbara; MADY, Charles; MARTINELLI, Martino; FILHO, Roberto Kalil; ROCHITTE, Carlos E.bookPart Doenças de chagas(2016) IANNI, Barbara Maria; MADY, Charles; RIBEIRO, Antonio Luiz Pinho