FRANCISCO RAFAEL MARTINS LAURINDO
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/64, Hospital das Clínicas, Faculdade de Medicina - Líder
44 resultados
Resultados de Busca
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conferenceObject Reflex modulation of vasomotor sympathetic and peripheral autonomic control on hypertension: Sequential effects of aerobic training(2020) MASSON, Gustavo Santos; FERNANDES, Denise; YSHII, Lidia; SOARES, Pedro Paulo; LAURINDO, Francisco R.; SCAVONE, Cristoforo; MICHELINIL, Lisete C.conferenceObject Beneficial effects of physical exercise on functional capacity and skeletal muscle oxidative stress in rats with aortic stenosis-induced heart failure(2016) GOMES, M. J.; MARTINEZ, P. F.; PAGAN, L. U.; LIMA, A. R. R.; DAMATTO, R. L.; CEZAR, M. D. M.; FERNANDES, A. A. H.; FERNANDES, D. C.; LAURINDO, F. R.; OKOSHI, K.; OKOSHI, M. P.conferenceObject Lifestyle in wine drinkers and abstemious: the relationship of coronary lesions, calcium score and risk factors(2012) MOCHIDUKY, Roberta I.; ROCHITTE, Carlos E.; FAVARATO, Desiderio; ALBUQUERQUE, Cicero P.; GONSALVES, Cibele Regina L.; LAURINDO, Francisco Rafael M.; HUEB, Whady A.; LUZ, Protasio DaIntroduction: Red wine (RW) protects the cardiovascular system but objective evidence based on coronary status is lacking. Objectives: To assess the effects of chronic RW consumption upon coronary lesion burden. Methods: We performed Coronary Computed Tomographic Angiography in 204 male subjects whose mean age was 58.95±7.3 years and related lesions to risk factors (RF). One hundred were chronic RW drinkers who consumed at least one glass of RW wine/day, 4 –5 times/week, in the last 5 years and 104 were abstemious. Results: RW drinkers consumed 25.78 gr alcohol/day vs 0 among abstemious; they also ingested more calories (2118.50kcal vs 1776.21kcal daily; p<0.01) mainly from saturated fats (22.98 g vs16.51g; p<0.05) than abstemious. Abstemious, however, ingested more fibers (22.73 gr vs17.49 gr; p<0.05). There were no significant differences regarding age, smoking, BMI, arterial hypertension, diabetes, LDL and triglycerides. Psychological factors including anxiety, depression and stress also were similar. However, plasma glucose was lower (97.5±18.3 mg% vs105.9±32.0 mg %; p<0.06) and HDL was higher (46.9±10.9 mg% vs 39.5±9.0 mg%;p<0.01) in RW drinkers compared to abstemious. Calcium score was higher on RW drinkers than in abstemious(144.43±362.2 vs 122.05±370.26; p<0.004). Lesions were classified as absent or 50%. Considering LM, ADA, RCA and Cx in proximal, median and distal portions, plus 3 marginal, 3 diagonal and 2 terminal RCA branches, 3672 segments were included in the analysis. There were no significant differences regarding lesions severity between groups, except for more frequent zero lesions in proximal Cx (86.3 x 71.4 %; p<0.016). Conclusion: Despite higher caloric intake and saturated fats, RW drinkers have similar coronary lesion burden; calcium score, however, was higher compared to abstemious. Higher HDL cholesterol as cribed to RW drinking and lower plasma glucose may have protective roles.- Nitroarachidonic Acid (NO(2)AA) Inhibits Protein Disulfide Isomerase (PDI) Through Reversible Covalent Adduct Formation with Critical Cysteine Residues(2016) GONZALEZ-PERILLI, Lucia; MASTROGIOVANNI, Mauricio; FERNANDES, Denise; RUBBO, Homero; LAURINDO, Francisco; TROSTCHANSKY, Andres
conferenceObject Polyphenol-Rich Extract of Syzygium cumini Leaf Reduces Non-alcoholic Fatty Liver Disease in MSG-obese Mice by a Joint Action on Insulin Resistance and Endoplasmic Reticulum Stress(2017) FRANCA, Lucas Matins; SANTOS, Pamela Costa dos; FLISTER, Karla Frida Torres; VALE, Caroline Castro; SANCHES, Jonas Rodrigues; BENEVIDES, Renata Ohana Alves; RIBEIRO, Nathalee Liberal Xavier; LAURINDO, Francisco Rafael Martins; PAES, Antonio Marcus de Andrade- EXTRACELLULAR VESICLES AS PARACRINE REDOX REGULATORS OF THROMBOSIS AND HAEMOSTASIS(2023) GASPAR, Renato S.; LAURINDO, Francisco R. M.
conferenceObject Early exposure to high-sucrose diet triggers hippocampal endoplasmic reticulum-stress in young rats(2016) PAES, Antonio Marcus de Andrade; PINTO, Bruno Araujo Serra; MELO, Thamys Marinho; FLISTER, Karla Frida Torres; FRANCA, Lucas Martins; TANAKA, Leonardo Yudi; LAURINDO, Francisco Rafael MartinsconferenceObject Sustained Exposure to High-Sucrose Diet Triggers Endoplasmic Reticulum Stress in Hippocampus and Anticipates Cognitive and Motor Impairments in Adults Rats(2017) PINTO, Bruno Araujo Serra; MELO, Thamys Marinho; FLISTER, Karla Frida Torres; FRANCA, Lucas Martins; KAJIHARA, Daniela; MOREIRA, Vanessa Ribeiro; PEREIRA, Silma Regina Ferreira; LAURINDO, Francisco Rafael Martins; PAES, Antonio Marcus De Andrade- PDIA1 overexpression activates acutely Nox1 NADPH oxidase in VSMC(2015) GONCALVES, Renata; ZANATA, Daniela; STRAUSS, Bryan; LAURINDO, Francisco Rafael; FERNANDES, Denise de Castro
conferenceObject Methotrexate associated with a lipid core nanoparticle prevented the dilation and dissection of the aortic arch in mice with Marfan syndrome(2020) GUIDO, M. C.; LOPES, N. M.; I, C. Albuquerque; TAVARES, E. R.; JENSEN, L.; V, L. Pereira; KALIL-FILHO, R.; LAURINDO, F. R. M.; MARANHAO, R. C.