LUCIANA DE PAULA SAMORANO
Projetos de Pesquisa
Unidades Organizacionais
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
LIM/56 - Laboratório de Investigação em Dermatologia e Imunodeficiências, Hospital das Clínicas, Faculdade de Medicina
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bookPart Manifestações Cutâneas Paraneoplásicas(2016) SAMORANO, Luciana de Paula; FESTA NETO, Cyro; SANCHES JUNIOR, José Antonio- Evaluation of the tolerability and safety of a 0.015% ingenol mebutate gel compared to 5% 5-fluorouracil cream for the treatment of facial actinic keratosis: a prospective randomized trial(2015) SAMORANO, L. P.; TOREZAN, L. A.; SANCHES, J. A.BackgroundFive per cent 5-fluorouracil (5-FU) cream is a well-established treatment for actinic keratosis (AK), and ingenol mebutate gel (IMB) is a novel topical field-directed therapy. ObjectiveTo compare the tolerability and safety of IMB with that of 5-FU for the treatment of facial AK. MethodsAn open-label, prospective, randomized, controlled clinical trial with 100 patients with AKs within a 25-cm(2) contiguous field on the face was conducted. IMB was applied daily for three consecutive days. 5-FU was applied twice a day for 4weeks. The treatment effect and the adverse events were evaluated at baseline and on days 2, 3, 4, 8, 15, 22, 29, 36 and 43 for intent-to-treat populations. ResultsThe mean (SD) maximum local skin reactions (LSR) for patients treated with IMB was 10.85 (+/- 3.12), compared with 10.86 (+/- 3.55) for those who received 5-FU. Patients in the IMB group presented LSR that peaked at day 4 and almost completely regressed after 15days. Differently, in the 5-FU group, the LSR peaked at day 29 and lasted until visit 36. Additionally, the area under the curve (LSRxvisit) was significantly smaller for IMB. No differences between the treatments for pruritus, pain, tearing, conjunctival hyperaemia or headaches were noted, but the eyelid oedema rate was higher for IMB group. No significant difference in the proportion of dropouts was observed between groups. Both treatments demonstrated a suitable safety profile. ConclusionFor treating AKs, the local skin reactions in the IMB group were more short-lived compared with those of 5-FU, but both treatments seemed to be safe and tolerable.
conferenceObject Evaluation of the tolerability and safety of 0.015% ingenol mebutate gel compared to 5% 5-fluorouracil cream for the treatment of facial actinic keratosis: A prospective randomized trial(2015) SAMORANO, Luciana Paula; ANTONIOTOREZAN, Luis; SANCHES, Jose AntonioconferenceObject Profile of patients and characteristics of admissions to a tertiary dermatology ward in Sao Paulo, Brazil(2012) SAMORANO, Luciana de Paula; FESTA NETO, Cyro; SANCHES, Jose Antonio; QUITERIO, Ligia MariaDermatology is primarily an outpatient clinical and surgical specialty, but it also plays important roles in the care of inpatients who are admitted to dermatology beds. The aim of this study was to assess the epidemiologic, clinical, and laboratory data of patients admitted to the Dermatology Division of Hospital das Cl ınicas da Faculdade de Medicina da Universidade de São Paulo. We performed a retrospective study of patients admitted to dermatology beds between September 1, 2002, and September 30, 2010. The following variables were analyzed: age, gender, ethnicity, length of stay, dermatologic disease, comorbidities, hospital infection, transfer to the intensive care unit (ICU), and mortality. During this 8-year period, 3308 admissions were analyzed. The most frequent admissions were for infections and infestation (18.0%) andeczema/dermatitis (17.8%). The median length of stay was 13.0 days(SD ± 13). We observed longer admissions for immunobullous disorders (mean, 21.8 days) and chronic ulcers (mean, 20.6 days). Admissions were shorter for benign (mean, 4.0 days) and malignant cutaneous neoplasms (mean, 4.4 days). The mean number of comorbidities per patient was 1.0 (SD ± 1.2) and among the most frequent were hypertension and diabetes mellitus. The rate of hospital infection was 6.2% with the blood stream infection regarded as the most common, and Staphylococcus aureu s as the most infectious agent found in culture. Of the admitted patients, 3.7% were transferred to ICU and 2.5% passed away. In these groups, the most common dermatological diagnosis was immunobullous diseases, and the mean of hospital length stay and hospital infection rate were higher in comparison with the total group of patients. A ward organized and specially intended for the care of patients with dermatologic disease and cutaneous/mucosal manifestations of systemic diseases often provide better medical and nursing care in addition to cost effectiveness. Higher valuation of dermatology inpatient services should be necessary in order to attempt to expand the availability of dermatology beds, mainly in tertiary hospitals, taking into consideration the higher potential of severity of the dermatologic diseases found in many patients referred to this kind of service.- Inpatient dermatology: profile of patients and characteristics of admissions to a tertiary dermatology inpatient unit in Sao Paulo, Brazil(2014) SAMORANO-LIMA, Luciana de Paula; QUITERIO, Ligia M.; SANCHES JR., Jose A.; NETO, Cyro FestaBackgroundDermatology is primarily an outpatient clinical and surgical specialty, but substantial numbers of patients are admitted to hospital for inpatient treatment in dermatology wards. MethodsWe performed a retrospective study of patients admitted to dermatology beds between September 1, 2002, and September 30, 2010. Patient data were analyzed for age, gender, ethnicity, length of stay (LoS), dermatologic disease, comorbidities, hospital-acquired infection (HAI), transfer to the intensive care unit (ICU), and mortality. ResultsA total of 3308 patients admitted during this 8-year period were identified for analysis. The most frequent admissions were for eczema/dermatitis (17.5%) and cutaneous infections (15.9%). The mean LoS was 13.0days. The meanstandard deviation (SD) number of comorbidities per patient was 1.0 +/- 1.2, among the most frequent of which were hypertension and diabetes mellitus. The rate of HAI was 6.2%; bloodstream infection was regarded as the most commonly acquired type and Staphylococcus aureus as the infectious agent most commonly found in culture. Of the patients admitted, 3.7% were transferred to the ICU and 2.5% died. In these latter two groups, the most common dermatologic diagnoses were immunobullous diseases, and the mean hospital LoS and rate of HAI were higher than in the total admissions cohort. ConclusionsHigher value should be placed on dermatology inpatient services in order to expand the availability of dermatology beds, mainly in tertiary hospitals, in view of the potentially high severity of the dermatologic diseases found in many patients referred to this type of service.