JULIANO PINHEIRO DE ALMEIDA

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Instituto de Ortopedia e Traumatologia, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/08 - Laboratório de Anestesiologia, Hospital das Clínicas, Faculdade de Medicina

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  • article 42 Citação(ões) na Scopus
    Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery
    (2019) EDWARDS, Mark R.; FORBES, Gordon; MACDONALD, Neil; BERDUNOV, Vladislav; MIHAYLOVA, Borislava; DIAS, Priyanthi; THOMSON, Ann; GROCOTT, Michael P. W.; MYTHEN, Monty G.; GILLIES, Mike A.; SANDER, Michael; PHAN, Tuong D.; EVERED, Lisbeth; WIJEYSUNDERA, Duminda N.; MCCLUSKEY, Stuart A.; ALDECOA, Cesar; RIPOLLES-MELCHOR, Javier; HOFER, Christoph K.; ABUKHUDAIR, Hussein; SZCZEKLIK, Wojciech; GRIGORAS, Ioana; KAHAN, Brennan C.; PEARSE, Rupert M.; MACDONALD, Neil; ABBOTT, Tom; MARTIN, Tim; JANUSZEWSKA, Marta; NIEBRZEGOWSKA, Edyta; BEKELE, Solana; PATES, Katherine; HAINES, Ryan; WALKER, Sophie; FOWLER, Alexander; OLIVEIRA, Monica; WHALLEY, Jan; STEPHENS, Tim; AMARAL, Vanessa Da Silva; MAY, Shaun; MANOU, Vasi; JONES, Tim; DUNKLEY, Steven; PAKATS, Mari-Liis; GRIFFITHS, Bethan; FERNANDEZ, Maria; EDWARDS, Mark; JONAS, Max; BOLGER, Clare; COLLINGS, Nikki; BURNISH, Rachel; KELLEHER, Mort; DAWSON, Heidi; LANG, Alastair; CAMPBELL, Rachael; REA, Nicola; CLARK, Sarah; BLUNT, Mark; ROSBERGEN, Melissa; HODGSON, Ruth; WITTENBERG, Marc; FILIPE, Helder; GLEESON, Yvonne; PAKOU, Glykeria; SZAKMANY, Tamas; GUNTER, Una; HODKINSON, Gemma; REAY, Michael; GIDDA, Ranjit; ALLCOCK, Clare; COLE, Andrea; WATTS, Angela; GARDNER, Wendy; TINDALL, Mark; ANUMAKONDA, Vikram; AGARWAL, Nipun; PRICE, Tracey; CLARK, Philip; THOMPSON, Robert; FOWLER, Susan; GRAY, Karan; MCGREGOR, Amanda; SMITH, Tim; WILSON, Toni; GUHA, Abhik; HODGSON, Adrian; MCSKEANE, Anna; BARBERIS, Luigi; MOHAMED, Mohamed; PRENTICE, Scott; SAUNDERS, Zoe; RATNAM, Valli; PAWA, Nikhil; SAYAN, Amrinder; THANKACHEN, Mini; SVENSSON, Marie-Louise; RAJ, Ashok; AHMAD, Nadeem; IVERMEE, Clare; CASHMAN, Josephine; SMEE, Elizabeth; KANAPECKAITE, Lina; Tuong Phan; EVERED, Lis; CORCORAN, Petrea; FITZGERALD, Emily; PEYTON, Philip; BUCKLEY, Aisling; BAULCH, Sarah; CLAXTON, Gayle; HARRIS, Saskia; SIDIROPOLOUS, Sofia; ALMEIDA, Juliano Pinheiro de; SIMOES, Claudia; GALAS, Filomena Regina B. G.; HAJJAR, Ludhmila Abrahao; CAMARA, Ligia; MALBOUISSON, Luiz Marcelo Sa; SOARES, Sanzio Dupim; FERNANDES, Claudia Regina; JOAQUIM, Eduardo Henrique Giroud; STEFANI, Luciana Cadore; FALCAO, Luiz Fernando; SALGADO, Marcello; GUIMARAES, Gabriel Nunes; GOMES, Mauricio Daher Andrade; LINEBURGER, Eric; NAVARRO, Lais; SALLES, Luiz Carlos; AZI, Liana Maria Torres de Araujo; PRADO, Ricardo Goncalves; BENEDETTI, Roberto Henrique; GODOY, Eudes Paiva de; BASTOS, Flavio Andrade; SILVA, Ricardo Jose Curioso da; SANTOS, Wagner Farias dos; MCCLUSKEY, Stuart; WIJEYSUNDERA, Duminda; PAZMINO-CANIZARES, Janeth; PAROTTO, Matteo; WASOWICZ, Marcin; BEATTIE, Scott; MEINERI, Massimiliano; CLARKE, Hance; LADHA, Karim; JERATH, Angela; AYACH, Nour; POONAWALA, Humara; SELLERS, Daniel; DUNCAN, Dallas; CARROLL, Jo; HUDSON, Chris; VLYMEN, Janet van; JAEGER, Melanie; SHELLEY, Jessica; SHORE, Debbie DuMerton; MCQUAIDE, Sheila; RICHEBE, Philipe; GODIN, Nadia; GOBERT, Quentin; FORTIER, Louis Philippe; VERDONCK, Oliver; SATO, Hiroaki; SCHRICKER, Thomas; CODERE-MARUYAMA, Takumi; LATTERMANN, Ralph; HATZAKORZIAN, Roupen; MOORE, Albert; SATO, Tamaki; FUNK, Duane; KOWALSKI, Stephen; GIRLING, Linda; MONTEROLA, Marita; FIDLER, Kelsi; SANDER, Michael; MARKMANN, Melanie; SCHULTE, Dagmar; SINGER, Rabea; KOCH, Christian; RUHRMANN, Sophie; HABIG, Lukas; EDINGER, Fabien; SCHNECK, Emmanuel; TRESKATSCH, Sascha; ERTMER, Martin; TRAUZEDDEL, Ralf-Felix; WEYLAND, Andreas; DIERS, Anja; GROTE, Thomas; PABEL, Svenja; LIPKA, Alien; NANNEN, Luhas; FLEISCHER, Andreas; WITTMANN, Maria; WINKLER, Anja; NEUMANN, Claudia; FINGERHUT, Marie-Louise; EHRENTRAUT, Heidi; GUTTENTHALER, Vera; HERINGLAKE, Matthias; BRANDT, Sebastian; OLSSON, Silke; SCHMIDT, Christian; SCHEMKE, Simon; MURAT, Lennart; KHUDAIR, Hussein Abu; FARHOUD, Esam; GHIDAN, Ahmad; MASRI, Mahmoud Al; KWIAK, Sameer Abu; ABDEL-NABI, Helen; GRIGORAS, Ioana; RISTESCU, Irina; JITARU, Iulia; MANOLE, Madalin; RUSU, Daniel; GATA, Angelica; ALDECOA, Cesar; GONZALEZ, Alba Perez; ALFONSO, Silvia Martin; PERZ, Laura Vaquero; FEIJOO, Jesus Rico; GUERRA, Yessica; HERRERO, Alba; RIPOLLES-MELCHOR, Javier; ABAD-MOTOS, Ane; PABLO, Elena Lucena de; MARTINEZ-HURTADO, Eugenio; ABAD-GURUMETA, Alfredo; SALVACHUA-FERNANDEZ, Rut; NOZAL-MATEO, Beatriz; NADAL, Miriam de; GALAN, Patricia; VISAUTA, Elena Camio; PERAL, Esther Cano; PRAT, Ivette Chocron Da; SUAREZ, Susana Gonzalez; PERAL, Cano; UNA-OREJON, Rafael; CALDERA-ALVAREZ, Maria V.; FERNANDEZ-FRANCOS, Silvia; DAVILA, Azahara Sancho; ORTOLA, Carlos Ferrando; GUTIERREZ, Andrea; MUGARRA, Ana; ROMERO, Esther; SORO, Marina; GRACIA, Estefania; POZO, Natividad; VILLAFANE, Ana Perez; DIEZ, Ana Fernandez; SANCHEZ, Cristina Garcia Miguel; BURON, Fernando Diez; BLANCO, Rodrigo Perez; DURAN, Marina Varela; PARADA, Pilar Diaz; TORRES, Marina Barreiro; RIVAS, Marta Casalderrey; BRAGE, Susana Marcelo; CASTRO, Ana Maria Gonzalez; CONDE, Maria Jose Pampin; PARDAL, Cristina Barreiro; BEN, Maria Rosa Taboada; PEREZ, Ana; SANCHO, Jaime Miralles; ALARCON, Maria Mercader; HOFER, Christoph; MARIOTTI, Sergio; MARCOLINO, Isabel; WINTER, Andreas; MCGRANE, Tracy; CRAVEN, Debra; TURNBO, Teresa; MAYO, Gail; CAMPBELL, Derwin; KLINTWORTH, Steven; TILLEY, Amanda; WEINSTEIN, Mitchell; HORAN, Annamarie; CHOWDARY, Rupa; CARLON, Vittoria Arslan; BALASINORWALA, Tasneem; YANG, Gloria
    Introduction Postoperative morbidity and mortality in older patients with comorbidities undergoing gastrointestinal surgery are a major burden on healthcare systems. Infections after surgery are common in such patients, prolonging hospitalisation and reducing postoperative short-term and long-term survival. Optimal management of perioperative intravenous fluids and inotropic drugs may reduce infection rates and improve outcomes from surgery. Previous small trials of cardiac-output-guided haemodynamic therapy algorithms suggested a modest reduction in postoperative morbidity. A large definitive trial is needed to confirm or refute this and inform widespread clinical practice. Methods The Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial is a multicentre, international, parallel group, open, randomised controlled trial. 2502 high-risk patients undergoing major elective gastrointestinal surgery will be randomly allocated in a 1: 1 ratio using minimisation to minimally invasive cardiac output monitoring to guide protocolised administration of intravenous fluid combined with low-dose inotrope infusion, or usual care. The trial intervention will be carried out during and for 4 hours after surgery. The primary outcome is postoperative infection of Clavien-Dindo grade II or higher within 30 days of randomisation. Participants and those delivering the intervention will not be blinded to treatment allocation; however, outcome assessors will be blinded when feasible. Participant recruitment started in January 2017 and is scheduled to last 3 years, within 50 hospitals worldwide. Ethics/dissemination The OPTIMISE II trial has been approved by the UK National Research Ethics Service and has been approved by responsible ethics committees in all participating countries. The findings will be disseminated through publication
  • article 178 Citação(ões) na Scopus
    Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non-cardiac surgery setting: systematic review and meta-analysis
    (2016) DOCHERTY, Annemarie B.; O'DONNELL, Rob; BRUNSKILL, Susan; TRIVELLA, Marialena; DOREE, Carolyn; HOLST, Lars; PARKER, Martyn; GREGERSEN, Merete; ALMEIDA, Juliano Pinheiro de; WALSH, Timothy S.; STANWORTH, Simon J.
    OBJECTIVE To compare patient outcomes of restrictive versus liberal blood transfusion strategies in patients with cardiovascular disease not undergoing cardiac surgery. DESIGN Systematic review and meta-analysis. DATA SOURCES Randomised controlled trials involving a threshold for red blood cell transfusion in hospital. We searched (to 2 November 2015) CENTRAL, Medline, Embase, CINAHL, PubMed, LILACS, NHSBT Transfusion Evidence Library, ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, ISRCTN Register, and EU Clinical Trials Register. Authors were contacted for data whenever possible. TRIAL SELECTION Published and unpublished randomised controlled trials comparing a restrictive with liberal transfusion threshold and that included patients with cardiovascular disease. DATA EXTRACTION AND SYNTHESIS Data extraction was completed in duplicate. Risk of bias was assessed using Cochrane methods. Relative risk ratios with 95% confidence intervals were presented in all meta-analyses. Mantel-Haenszel random effects models were used to pool risk ratios. MAIN OUTCOME MEASURES 30 day mortality, and cardiovascular events. RESULTS 41 trials were identified; of these, seven included data on patients with cardiovascular disease. Data from a further four trials enrolling patients with cardiovascular disease were obtained from the authors. In total, 11 trials enrolling patients with cardiovascular disease (n= 3033) were included for meta-analysis (restrictive transfusion, n= 1514 patients; liberal transfusion, n= 1519). The pooled risk ratio for the association between transfusion thresholds and 30 day mortality was 1.15 (95% confidence interval 0.88 to 1.50, P= 0.50), with little heterogeneity (I-2= 14%). The risk of acute coronary syndrome in patients managed with restrictive compared with liberal transfusion was increased (nine trials; risk ratio 1.78, 95% confidence interval 1.18 to 2.70, P= 0.01, I-2= 0%). CONCLUSIONS The results show that it may not be safe to use a restrictive transfusion threshold of less than 80 g/L in patients with ongoing acute coronary syndrome or chronic cardiovascular disease. Effects on mortality and other outcomes are uncertain. These data support the use of a more liberal transfusion threshold (> 80 g/L) for patients with both acute and chronic cardiovascular disease until adequately powered high quality randomised trials have been undertaken in patients with cardiovascular disease.