VANDERSON GERALDO ROCHA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
Instituto Central, Hospital das Clínicas, Faculdade de Medicina
LIM/31 - Laboratório de Genética e Hematologia Molecular, Hospital das Clínicas, Faculdade de Medicina - Líder
8 resultados
Resultados de Busca
Agora exibindo 1 - 8 de 8
bookPart Leucemias Crônicas(2014) NOVIS, Yana; ROCHA, Vanderson; RODRIGUES, Celso Arrais; FERREIRA, Fernando Blumm; FONSECA, Guilherme Hencklain; VILELA, Volney; TUCUNDUVA, LucianabookPart Síndrome Mielodisplásica (SMD)(2014) NOVIS, Yana; ROCHA, Vanderson; RODRIGUES, Celso Arrais; FERREIRA, Fernando Blumm; FONSECA, Guilherme Hencklain; VILELA, Volney; TUCUNDUVA, LucianabookPart Leucemias Agudas(2014) NOVIS, Yana; ROCHA, Vanderson; RODRIGUES, Celso Arrais; FERREIRA, Fernando Blumm; FONSECA, Guilherme Hencklain; VILELA, Volney; TUCUNDUVA, LucianabookPart Mieloma Múltiplo(2014) NOVIS, Yana; ROCHA, Vanderson; RODRIGUES, Celso Arrais; FERREIRA, Fernando Blumm; FONSECA, Guilherme Hencklain; VILELA, Volney; TUCUNDUVA, LucianabookPart Doença de Hodgkin(2014) NOVIS, Yana; ROCHA, Vanderson; RODRIGUES, Celso Arrais; FERREIRA, Fernando Blumm; FONSECA, Guilherme Hencklain; VILELA, Volney; TUCUNDUVA, Luciana- Autoimmune manifestations in SCID due to IL7R mutations: Omenn syndrome and cytopenias(2014) ZAGO, Claudia Augusta; JACOB, Cristina Miuki Abe; DINIZ, Edna Maria de Albuquerque; LOVISOLO, Silvana Maria; ZERBINI, Maria Claudia Nogueira; DORNA, Mayra; WATANABE, Leticia; FERNANDES, Juliana Folloni; ROCHA, Vanderson; OLIVEIRA, Joao Bosco; CARNEIRO-SAMPAIO, MagdaB+NK+SCID (severe combined immunodeficiency) due to IL7R alpha deficiency represents approximately 10% of American SCID cases. To better understand the spectrum of autoimmune disorders associated with IL7R alpha deficiency, we describe two unrelated IL7R alpha-deficient female SCID infants whose clinical picture was dominated by autoimmune manifestations: one with intrauterine Omenn syndrome (OS) and another with persistent thrombocytopenic purpura since 4 months of age. The OS baby harbored a homozygous p.C118Y mutation in IL7R. She presented dense eosinophilic infiltrates in several organs, including pancarditis, which may have contributed to her death (on the 2nd day of life). B cells were observed in lymph nodes, spleen, bone marrow and thymus. The second patient harbored compound heterozygous p.01 8Y and p.I121NfsX8 mutations. She underwent a successful unrelated cord blood transplant. In conclusion, early OS can be observed in patients with IL7R mutations, and autoimmune cytopenias could also complicate the clinical course of SCID babies with this type of defect. (C) 2014 Published by Elsevier Inc. on behalf of American Society for Histocompatibility and Immunogenetics.
bookPart Linfoma Não-Hodgkin(2014) NOVIS, Yana; ROCHA, Vanderson; RODRIGUES, Celso Arrais; FERREIRA, Fernando Blumm; FONSECA, Guilherme Hencklain; VILELA, Volney; TUCUNDUVA, LucianaconferenceObject Hemophagocytic Syndrome Due to Perforin-Deficiency in Three Brazilian Infants: Immunization Could be the Trigger?(2014) JACOB, Cristina Miuki Abe; SANTOS, Cristiane de Jesus Nunes dos; GOMES, Monizi Campelo; PASTORINO, Antonio Carlos; DORNA, Mayra de Barros; FERNANDES, Juliana Folloni; CASTRO, Ana Paula B. Moschione; ROCHA, Vanderson; HAMERSCHLAK, Nelson; SAINT-BASILE, Genevieve de; CARNEIRO-SAMPAIO, Magda M. Sales