MARIA LUCIA HIRATA KATAYAMA
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Radiologia, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Somatic mutations in early onset luminal breast cancer(2018) ENCINAS, G.; SABELNYKOVA, V. Y.; LYRA, E. C. de; KATAYAMA, M. L. H.; MAISTRO, S.; VALLE, P. W. M. V.; PEREIRA, G. F. L.; RODRIGUES, L. M.; SERIO, P. A. M. P.; GOUVêA, A. C. R. C. de; GEYER, F. C.; BASSO, R. A.; PASINI, F. S.; DIZ, M. P. E.; BRENTANI, M. M.; GóES, J. C. G. S.; CHAMMAS, R.; BOUTROS, P. C.; FOLGUEIRA, M. A. A. K.Breast cancer arising in very young patients may be biologically distinct; however, these tumors have been less well studied. We characterized a group of very young patients (≤ 35 years) for BRCA germline mutation and for somatic mutations in luminal (HER2 negative) breast cancer. Thirteen of 79 unselected very young patients were BRCA1/2 germline mutation carriers. Of the non-BRCA tumors, eight with luminal subtype (HER2 negative) were submitted for whole exome sequencing and integrated with 29 luminal samples from the COSMIC database or previous literature for analysis. We identified C to T single nucleotide variants (SNVs) as the most common base-change. A median of six candidate driver genes was mutated by SNVs in each sample and the most frequently mutated genes were PIK3CA, GATA3, TP53 and MAP2K4. Potential cancer drivers affected in the present non-BRCA tumors include GRHL2, PIK3AP1, CACNA1E, SEMA6D, SMURF2, RSBN1 and MTHFD2. Sixteen out of 37 luminal tumors (43%) harbored SNVs in DNA repair genes, such as ATR, BAP1, ERCC6, FANCD2, FANCL, MLH1, MUTYH, PALB2, POLD1, POLE, RAD9A, RAD51 and TP53, and 54% presented pathogenic mutations (frameshift or nonsense) in at least one gene involved in gene transcription. The differential biology of luminal early-age onset breast cancer needs a deeper genomic investigation. © Encinas et al.
- Survival and prognosis of young adults with gastric cancer(2018) CORMEDI, Marina Candido Visontai; KATAYAMA, Maria Lucia Hirata; GUINDALINI, Rodrigo Santa Cruz; FARAJ, Sheila Friedrich; FOLGUEIRA, Maria Aparecida Azevedo KoikeOBJECTIVES: Survival data for young adults (YA) with gastric cancer is conflicting and scarce in Brazil. The aim of this study was to compare the clinicopathological factors and survival rates of younger and older patients with gastric cancer. METHODS: Hospital registries for 294 gastric cancer patients from a reference cancer hospital in Sao Paulo, Brazil, were consulted for the retrieval of clinicopathological information and follow-up time. Patients were placed into the following groups: YA ( <= 40 years; N.71), older adult (OA: 41 to 65 years; N=129) and elderly (E: >= 66 years; N=94). Differences were assessed through Pearson's chi(2) test, Kaplan-Meier analysis, Log rank test and Cox regression. RESULTS: More YA were diagnosed with advanced disease (clinical stage III/IV: 86.7% YA, 69.9% OA, and 67% E); however, fewer E patients underwent surgery (64.3% YA, 72.7% OA, and 52.4% E). The median overall survival among all patients was 16 months, and the overall survival rate was not significantly different among the age groups (p=0.129). There were no significant differences in the disease-free survival rate. Metastatic disease at diagnosis (HR=4.84; p <0.01) was associated with an increased hazard of death for YA. CONCLUSION: Overall survival was similar among age groups. Metastatic disease at diagnosis was the only factor associated with a poorer prognosis in YA. These results suggest that younger patients deserve special attention regarding the detection of early stage disease.
- Pathology and molecular biology(2018) FOLGUEIRA, M. A. A. K.; CORMEDI, M. C. V.; SACCARO, D. M.; KATAYAMA, M. L. H.
conferenceObject Stromal cell signature in luminal breast cancer associated with response to neoadjuvant chemotherapy.(2018) KATAYAMA, Maria Lucia H.; VIEIRA, Rene A. da Costa; ROELA, Rosimeire A.; ANDRADE, Victor P.; LIMA, Luiz Guilherme C. A. de; ENCINAS, Giselly; KERR, Ligia M.; MAISTRO, Simone; BRENTANI, M. Mitzi; FOLGUEIRA, Maria A. A. KoikeconferenceObject Germline BRCA1 and BRCA2 mutations in Brazilian ovarian and breast cancer patients.(2018) MAISTRO, Simone; ENCINAS, Giselly; NAGY, Tauana; TEIXEIRA, Natalia; KATAYAMA, Maria Lucia H.; GOUVEA, Ana Carolina R. C.; DIZ, Maria del Pilar E.; CHAMMAS, Roger; BOCH, Geertruida H. de; FOLGUEIRA, Maria Aparecida A. K.- Survival Analysis in Young Adults with Lung Carcinoma(2018) NICOLAU, J.; FOLGUEIRA, M. A. Koike; ROELA, R.; MAISTRO, S.; KATAYAMA, M. L.; ELUF NETO, J.; LUIZAGA, C.; RIBEIRO, K.; CASTRO JR., G. De