HOMERO PINTO VALLADA FILHO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Psiquiatria, Faculdade de Medicina - Docente
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
LIM/23 - Laboratório de Psicopatologia e Terapêutica Psiquiátrica, Hospital das Clínicas, Faculdade de Medicina - Líder
17 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 17
- GENOME-WIDE DNA METHYLATION ANALYSIS IN THE SALIVA OF CRACK COCAINE DEPENDENTS(2019) CAMILO, Caroline; MASCHIETTO, Mariana; NEGRAO, Andre Brooking; RIBEIRO, Marcelo; LARANJEIRA, Ronaldo; BRENTANI, Helena; VALLADA, Homero
conferenceObject GAD1 POLYMORPHISMS ARE ASSOCIATED WITH GLUTAMATERGIC ACTIVITY IN THE ANTERIOR CINGULATE IN BIPOLAR I DISORDER(2017) SOEIRO-DE-SOUZA, Marcio; MACHADO-VIEIRA, Rodrigo; MORENO, Ricardo; CHILE, Thais; GOUVEIA, Gisele; PASTORELLO, Bruno; LEITE, Claudia; HENNING, Anke; OTADUY, Maria Concepcion; VALLADA, Homero- GENOME-WIDE ASSOCIATION STUDY OF COMORBID DEPRESSION AND ANXIETY SYMPTOMS IN AN EXTENDED PEDIGREE COHORT(2019) NEGRAO, Andre Brooking; TAPOROSKI, Tamara; ESTEBAN, Nubia; SCHANTZ, Malcolm von; VALLADA, Homero; PEREIRA, Alexandre Costa
- IDENTIFICATION OF NOVEL GWAS HITS FOR SEMANTIC VERBAL FLUENCY: RESULTS FROM A FAMILY-BASED STUDY(2019) TAPOROSKI, Tamara; SCHANTZ, Malcolm Von; HORIMOTO, Andrea R. V. R.; DUARTE, Nubia E.; POMPEIA, Sabine; EVANS, Simon; KRIEGER, Jose E.; VALLADA, Homero; NEGRAO, Andre Brooking; PEREIRA, Alexandre C.
- Genetic polymorphism in the cacna1c is associated with glutamatergic neurometabolites in the anterior cingulate cortex in bipolar disorder(2021) SCOTTI-MUZZI, E.; CHILE, T.; VALLADA, H.; OTADUY, M. C.; SOEIRO-DE-SOUZA, M. G.
conferenceObject Prefrontal cortex gamma-aminobutyric acid levels in bipolar I disorder determined using proton magnetic resonance spectroscopy(2014) SOEIRO-DE-SOUZA, M.; OTADUY, M. C. G.; MORENO, R. A.; MORENO, D. H.; VALLADA, H.conferenceObject The impact of CACNA1C risk allele on prefrontal age-related cortical thinning in bipolar I disorder(2016) SOEIRO-DE-SOUZA, M.; MORENO, R.; NERY, F.; MACHADO-VIEIRA, R.; CHAIM, K.; LAFER, B.; OTADUY, M.; VALLADA, H.- PER3 POLYMORPHISMS, MORNINGNESS-EVENINGNESS AND DEPRESSION: PRELIMINARY EVIDENCE IN A BRAZILIAN FAMILY-BASED COHORT, THE BAEPENDI HEART STUDY(2019) RUIZ, Francieli; TAPOROSKI, Tamara P.; MARTINEZ, Daniela; BEALE, Andrew; BEIJAMINI, Felipe; KRIEGER, Jose E.; KNUTSON, Kristen L.; PEREIRA, Alexandre; PEDRAZZOLI, Mario; VALLADA, Homero; SCHANTZ, Malcolm Von
- Association between CACNA1C gene rs100737 polymorphism and glutamatergic neurometabolites in bipolar disorder(2022) SCOTTI-MUZZI, Estevao; CHILE, Thais; VALLADA, Homero; OTADUY, Maria Concepcion Garcia; SOEIRO-DE-SOUZA, Marcio GerhardtAbnormalities in Ca 2 + homeostasis in Bipolar Disorders (BD) have been associated with impairments in glutamatergic receptors and voltage-gated calcium channels. Increased anterior cingulate cortex (ACC) glutamatergic neurometabolites have been consistently disclosed in BD by proton magnetic resonance spectroscopy ( 1 H-MRS). A single nucleotide polymorphism (SNP) in the CACNA1C gene (rs1006737), which encodes the alpha 1-C subunit of the L-type calcium channel, has been associated with BD and is reported to modulate intra-cellular Ca 2 + . Thus, this study aimed to explore the association of the CACNA1C genotype with ACC glutamatergic metabolites measured by 1 H-MRS in both BD and HC subjects. A total of 194 subjects (121 euthymic BD type I patients and 73 healthy controls (HC) were genotyped for CACNA1C rs1006737, underwent a 3-Tesla 1 H-MRS imaging examination and ACC glutamatergic metabolite were assessed. We found overall increased glutamatergic metabolites in AA carriers in BD. Specifically, higher Glx/Cr was observed in subjects with the AA genotype compared to both AG and GG in the overall sample (BD + HC). Also, female individuals in the BD group with AA genotype were found to have higher Glx/Cr compared to those with other genotypes. CACNA1C AA carriers in use of anticonvulsant medication had higher estimated Glutamine (Glx-Glu) than the other genotypes. Thus, this study suggest an association between calcium channel genetics and in- creased glutamatergic metabolites in BD, possibly playing a synergic role in intracellular Ca2+ overload and excitotoxicity.
conferenceObject ASSOCIATION OF LITHIUM RESPONSE TO TELOMERE LENGTH IN BIPOLAR DISORDER IN A BRAZILIAN COHORT(2017) MICHELON, Leandro; MARTINEZ, Daniela; CHILE, Thais; GOUVEIA, Gisele; CAMILO, Caroline; SCHALLING, Martin; VALLADA, Homero