CARLA CRISTINA GUSMON DE OLIVEIRA
Índice h a partir de 2011
8
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
4 resultados
Resultados de Busca
Agora exibindo 1 - 4 de 4
conferenceObject Probe-Based Confocal Endomicroscopy May Improve the Diagnosis of Clinical Complete Response After Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Neoplasia(2018) SAFATLE-RIBEIRO, Adriana; MARQUES, Carlos; PIRES, Clelma; BABA, Elisa; MEIRELLES, Luciana; FARAJ, Sheila; ARRAES, Livia; ARAUJO, Diogo; GUSMON, Carla; KAWAGUTI, Fabio; LENZ, Luciano; SIMAS, Marcelo; MARTINS, Bruno; NAHAS, Caio; NAHAS, Sergio; RIBEIRO JR., Ulysses; MALUF FILHO, Fauze- Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer(2018) GUSMON-OLIVEIRA, Carla Cristina; KUBOKI, Yeda Mayumi; PAULO, Gustavo Andrade de; LIMA, Marcelo Simas de; UEMURA, Ricardo Sato; MARTINS, Bruno Costa; TOLENTINO, Luciano Lenz; SAFATLE-RIBEIRO, Adriana Vaz; KULCSAR, Marco Aurelio; RIBEIRO JR., Ulysses; MALUF-FILHO, FauzeBackground. Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. It is not uncommon that PES is refractory to dilation sessions. This study aimed at evaluating the efficacy of Mitomycin C (MMC) endoscopic injection for the treatment of refractory pharyngoesophageal stenosis. Patients and methods. This is a prospective study in patients with dysphagia following head and neck cancer treatment, without evidence suggestive of tumor recurrence, and refractory to endoscopic treatment. These patients were submitted to endoscopic dilation of the stenotic segment with thermoplastic bougies, followed by injection of MMC. We repeated the endoscopic sessions every three weeks. Results. From January 2015 to May 2015, we treated 13 patients with PES. Three patients were initially enrolled in the study for refractory stricture. We observed adverse events in all of them, with intense neck pain and ulcer development, justifying the interruption of the trial. Conclusion. The repeated injection in the short interval of MMC in refractory PES is not recommended, because it resulted in serious adverse events.
conferenceObject CLINICAL AND ENDOSCOPIC FEATURES OF METASTASES TO THE GASTROINTESTINAL TRACT(2018) BENTO, Luiza H.; MINATA, Mauricio K.; PIRES, Clelma Batista; SCOMPARIN, Rodrigo Corsato; LENZ, Luciano; LIMA, Marcelo S. de; MARTINS, Bruno da Costa; GUSMON, Carla C.; KAWAGUTI, Fabio S.; PENNACCHI, Caterina; GEIGER, Sebastian N.; UEMURA, Ricardo S.; FRANCO, Matheus C.; PAULO, Gustavo A. de; BABA, Elisa R.; SAFATLE-RIBEIRO, Adriana V.; RIBEIRO, Ulysses; MALUF-FILHO, Fauze- Probe-based confocal endomicroscopy is accurate for differentiating gastric lesions in patients in a Western center(2018) SAFATLE-RIBEIRO, Adriana Vaz; BABA, Elisa Ryoka; SCOMPARIN, Rodrigo Corsato; FARAJ, Sheila Friedrich; LIMA, Marcelo Simas de; LENZ, Luciano; MARTINS, Bruno Costa; GUSMON, Carla; KAWAGUTI, Fabio Shiguehissa; PENNACCHI, Caterina; ZILBERSTEIN, Bruno; RIBEIRO JR., Ulysses; MALUF-FILHO, FauzeObjective: Probe-based confocal laser endomicroscopy (pCLE) technique may improve the diagnosis of gastric mucosal lesions allowing acquisition of high-resolution in vivo images at the cellular and microvascular levels. This study aims to evaluate the accuracy of pCLE for the differential diagnosis of non-neoplastic and neoplastic gastric lesions. Methods: Twenty gastric mucosal lesions from 10 patients were evaluated during endoscopic procedure and were examined by pCLE. Diagnostic pCLE was followed by biopsies or endoscopic resection of suspected lesions. A senior pathologist evaluated the specimens and was blinded to the pCLE results. Results: Patients' mean age was 68.3 (range, 42-83) years and six were men. Thirteen suspicious flat or elevated lesions (classified as 0-Is, 0-IIa or 0-IIa + IIc) and seven pre-malignant lesions (atrophy and intestinal metaplasia) were evaluated. One patient was studied during his long-term follow-up after partial gastrectomy and presented severe atrophy, intestinal metaplasia, and xanthomas at the stump mucosa. The location of gastric lesions was in the body (n=10 lesions), the antrum (n=9) and the incisura angularis (n=1). All neoplastic lesions and all but one benign lesion were properly diagnosed by pCLE. pCLE incorrectly diagnosed one small antrum lesion as adenoma, however the final diagnosis was intestinal metaplasia. The final histological diagnosis was neoplastic in 9 and benign lesions in 11. In this small case series, pCLE accuracy was 95% (19/20 lesions). Conclusions: pCLE is accurate for real time histology of gastric lesions. pCLE may change the management of patients with gastric mucosal lesions, guiding biopsies and endoscopic resection, and avoiding further diagnostic workup or unnecessary therapy.