RICARDO ALBERTO MORENO
Projetos de Pesquisa
Unidades Organizacionais
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina - Médico
36 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 36
conferenceObject Dorsal anterior cingulate lactate and glutathione levels in euthymic bipolar I disorder: 1H-MRS study(2016) SOEIRO-DE-SOUZA, M.; MORENO, R.; MORENO, D.; PASTORELLO, B.; HENNING, A.; OTADUY, M. C.conferenceObject The association between family functioning and childhood trauma and cognition in patients with bipolar disorder type I(2013) BIO, D. S.; MONTEIRO, R. O.; SOEIRO-DE-SOUZA, M.; MORENO, D.; MORENO, R. A.Objective: Bipolar disorder (BD) is characterized by high levels of childhood trauma as well as of cognitive dysfunction. Our aim is to investigate the association between these two factors in bipolar patients and in healthy controls. Methods: A total of 35 patients with BD in euthymia, aged between 18 and 40 years old, were recruited at Hospital das Clinicas in São Paulo, Brazil. Ninety four healthy volunteers (HC) (predominantly medical students) aged between 18 and 40 years old, with no current or past history of psychiatric disorder, were recruited from the University of São Paulo. Information about early life stress was obtained using the Childhood Trauma Questionnaire (CTQ). Cognitive function was assessed through a comprehensive and standardized neuropsychological test battery, including social cognition – Facial Emotional Recognized (FER). Results: In the BD group we observed: that physical abuse was significantly associated with reduced scores on verbal recall (p = 0.04) and with fewer recognized of “fear” faces (p = 0.02); sexual abuse and physical neglect were significantly associated with reduced scores on executive function scales (p = 0.02 to p = 0.04); emotional neglect was significantly associated only with reduced scores on recognized of “anger” faces; emotional abuse was significantly associated with reduced scores on attentional process (p = 0.02), verbal task from the Wechsler Abbreviated Scale of Intelligence (WASI) (p = 0.01), and recognized “anger” faces; pshysical neglect was yet significantly associated with reduced scores on verbal and performance tasks and IQ from the WASI (p = 0.02 to p < 0.001), and FER scores on the Emotion Hexagon (Hx) tests and e Ekman 60 Faces (EK60) total scores. In the control HC, Emotional Neglect and Physical Neglect was significantly associated with reduced scores on verbal and performance tasks and IQ from the WASI (p = 0.02 to p < 0.001), working memory (p = 0.01) and executive function (p = 0.01to p = 0.007); Emotional Neglect and Sexual Abuse was significantly associated with reduced scores on verbal fluency; and significantly reduced scores on FER was observed in emotional abuse (p = 0.03), Physical Neglect (p = 0.04 to p = 0.008) and Sexual Abuse (p = 0.04). Discussion: Our results indicate that childhood trauma is associated with a reduction in cognitive function across cognitive domains in patients with BD and HC, in particular social cognition, working memory and executive function as well as general cognition.conferenceObject Increased Anterior Cingulate Glutamate Levels in Euthymic Bipolar I Disorder: A 1h MRS Study(2012) SOEIRO-DE-SOUZA, Marcio G.; OTADUY, Maria C. G.; LEITE, Claudia C.; MACHADO-VIEIRA, Rodrigo; MORENO, RicardoconferenceObject The Role Of Dopamine Transporter Intron 8 VNTR Polymorphism In The Occurrence Of Depression In Temporal Lobe Epilepsy(2019) VINCENTIIS, S.; ALCANTARA, J.; RZEZAK, P.; KERR, D.; GATTAZ, W.; LINDEN JUNIOR, H. van der; ARRUDA, F.; SANTOS, B. dos; CHAIM-AVANCINI, T.; SERPA, M.; FERNANDES, F.; MORENO, R. A.; BUSATTO, G. F.; DEMARQUE, R.; VALENTE, K. D.; ALESSI, R.conferenceObject GAD1 POLYMORPHISMS ARE ASSOCIATED WITH GLUTAMATERGIC ACTIVITY IN THE ANTERIOR CINGULATE IN BIPOLAR I DISORDER(2017) SOEIRO-DE-SOUZA, Marcio; MACHADO-VIEIRA, Rodrigo; MORENO, Ricardo; CHILE, Thais; GOUVEIA, Gisele; PASTORELLO, Bruno; LEITE, Claudia; HENNING, Anke; OTADUY, Maria Concepcion; VALLADA, HomeroconferenceObject Influence of childhood trauma on personality development in bipolar patients and healthy controls(2013) MONTEIRO, R.; BIO, D. Soares; SOEIRO-DE-SOUZA, M.; MISSIO, G.; MORENO, D.; MORENO, R. A.Objective: Bipolar disorder (BD) is characterized by high levels of childhood trauma and they can be detrimental in relation to the formation of personality. The aim of this study is to investigate the association between childhood trauma and BD personality compared to healthy controls (HC). Methods: A total of 27 euthimic BD patients, aged between 18 and 40 years old, were recruited at Hospital das Clinicas in São Paulo, Brazil. Twenty HC (predominantly medical students) aged between 18 and 35 years old, with no current or past history of psychiatric disorder, were recruited from the University of São Paulo. Information about early life stress was obtained using the Childhood Trauma Questionnaire (CTQ). Personality Formation was assessed through NEO-PI-R personality test – based on the Big Five personality traits: Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience. Results: In the BD group the main significant associations were: physical abuse with concientiousness (p = 0.03); emotional neglect with agreeableness (p =0.03) and emotional abuse with conscientiousness (p = 0.04). There were no significant differences in HC group. Comparing BD and HC physical abuse was associated with concientiousness (p = 0.03) and emotion Neglecent was associated with agreeableness (p = 0.03). Discussion: Our results indicate that childhood trauma can be associated with personality traits in BD patients but not in HC, mainly regarding concientiousness and emotional neglect.conferenceObject The Burden of a Progressive Disease: Number of Manic Episodes and Lifetime History of Psychotic Symptoms Increases Dna Oxidation in Bipolar I Disorder(2012) SOEIRO-DE-SOUZA, Marcio G.; ANDREAZZA, Ana Cristina; MACHADO-VIEIRA, Rodrigo; YOUNG, Trevor; MORENO, RicardoconferenceObject Genetic polymorphisms of dopamine receptors are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis(2022) VINCENTIIS, S.; ALCANTARA, J. A.; RZEZAK, P.; KERR, D. S.; GATTAZ, W. F.; LINDEN JR., H. van der; SANTOS, B. dos; ARRUDA, F.; CHAIM-AVANCINI, T.; SERPA, M. H.; FERNANDES, F.; MORENO, R. A.; BUSATTO, G. F.; ALESSI, R.; DEMARQUE, R.; VALENTE, K. D.conferenceObject Psychoeducation efficacy and symptomatic and functional recovery in severe bipolar disorder(2012) PELLEGRINELLI, K. B.; COSTA, L. O.; SILVAL, K. I.; DIAS, V. V.; ROSO, M.; BANDEIRA, M.; MORENO, R. A.Background: Despite increasing recognition of the effectiveness of psychoeducation in the treatment of mood disorders, some factors related to severity of illness can negatively influence intervention results. Objective: To evaluate the efficacy of psychoeducation in the symptomatic and functional recovery, and quality of life improvement, of severe bipolar disorder (BD) patients. Methods: The sample comprised 55 patients with BD I and II in remission (Young Mania Rating Scale ≤6, and Hamilton Depression Rating Scale ≤7). Eighty percent of the patient sample had severe BD (6 or more mood episodes). Outpatients were randomly assigned to receive 16 sessions of psychoeducation (experimental group - EG) or 16 sessions of placebo without psychoeducation (control group - CG). Groups were evaluated at study baseline, midpoint, endpoint, and at 6 and 12 month follow ups. Results: No significant differences between the groups was found for the variables evaluated (mood symptoms, functioning and quality of life), except for overall clinical improvement, subjectively perceived by EG subjects. Both groups showed a trend towards improved clinical global impression and quality of life (environmental). No reduction in mood symptoms or improvement in psychosocial functioning was observed. Psychosocial treatment compliance was positively correlated with global functioning, social adjustment, sociability, and global clinical impression. These factors emerged as predictors of poor adherence. Limitations: The main limitations of the study were small sample size and disease severity. Conclusion: psychoeducation seems to be ineffective to improve symptoms (mood episodes) or functioning but led to an improvement of clinical global impression scores and quality of life (environment domain). Specific psychoeducation programs need to be developed for severe bipolar patients.- Intramuscular ketamine in depression, suicidal thoughts and anxiety: A report on two cases(2017) CIGOGNINI, M.; MORENO, R.