VERA LUCIA JORNADA KREBS
Projetos de Pesquisa
Unidades Organizacionais
Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
LIM/36 - Laboratório de Pediatria Clínica, Hospital das Clínicas, Faculdade de Medicina
6 resultados
Resultados de Busca
Agora exibindo 1 - 6 de 6
- Neonatal SARS-CoV-2 infection(2020) CARVALHO, Werther Brunow de; GIBELLI, Maria Augusta Cicaroni; KREBS, Vera Lucia Jornada; CALIL, Valdenise Martins Laurindo Tuma; NICOLAU, Carla Marques; JOHNSTON, Cintia
- Neonatal manifestations in COVID-19 patients at a Brazilian tertiary center COMMENT(2020) BEOZZO, Glenda Priscila Neves dos Santos; CARVALHO, Werther Brunow de; KREBS, Vera Lucia Jornada; GIBELLI, Maria Augusta Bento Cicaroni; ZACHARIAS, Romy Schmidt Brock; ROSSETTO, Larissa Elizabeth Schulz; FRANCISCO, Rossana Pulcinelli Vieira
- Artificial intelligence and machine learning in pediatrics and neonatology healthcare(2022) MATSUSHITA, Felipe Yu; KREBS, Vera Lucia Jornada; CARVALHO, Werther Brunow de
- Gray zone: mortality profile of newborns at the limit of viability(2019) CARVALHO, Werther Brunow de; MATSUSHITA, Felipe Yu; KREBS, Vera Lucia Jornada
- Menkes disease: importance of diagnosis with molecular analysis in the neonatal period(2015) COSTA, Larissa Sampaio de Athayde; PEGLER, Stephanie Pucci; LELLIS, Rute Facchini; KREBS, Vera Lucia Jornada; ROBERTSON, Stephen; MORGAN, Tim; HONJO, Rachel Sayuri; BERTOLA, Debora Romeo; KIM, Chong AeMenkes disease is a congenital disorder caused by changes in copper metabolism derived from mutations in the ATP7A gene. It is characterized by physical and neurological alterations. In the neonatal period, these alterations can be nonspecific, which makes early diagnosis a challenge. Diagnosis can be suspected when there are low levels of ceruloplasmin and serum copper. Molecular analysis confirms the diagnosis. Treatment is parenteral administration of copper histidine. We report a familial case with molecular confirmation. The proband had clinical and biochemical suspicious. Treatment with copper histidine was indicated, but initiated at the age of 2 months and 27 days only. He did not present improvements and died at 6 months. The mother became pregnant again, a male fetus was identified and copper histidine was manufactured during pregnancy. He was born healthy, biochemical markers were reduced and treatment was indicated. Molecular analysis was performed confirming mutation in both the mother and the proband, while the other son did not have mutation, so treatment was discontinued. We support the clinical relevance of molecular confirmation for the correct diagnosis and genetic counseling, once clinical findings in the neonatal period are nonspecific and early treatment with parenteral copper histidine must be indicated.
- CoronaVac can induce the production of anti-SARS-CoV-2 IgA antibodies in human milk(2021) CALIL, Valdenise Martins Laurindo Tuma; PALMEIRA, Patricia; ZHENG, Yingying; KREBS, Vera Lucia Jornada; CARVALHO, Werther Brunow de; CARNEIRO-SAMPAIO, Magda