PAULO MAGNO MARTINS DOURADO
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- Epicardial adipose tissue and carotid artery disease: Protocol for systematic review and meta-analysis(2018) ROEVER, Leonardo; RESENDE, Elmiro Santos; DINIZ, Angelica Lemos Debs; PENHA-SILVA, Nilson; O'CONNELL, Joao Lucas; GOMES, Paulo Fernando Silva; ZANETTI, Hugo Ribeiro; ROERVER-BORGES, Anaisa Silva; VELOSO, Fernando Cesar; SOUZA, Fernanda Rodrigues de; DUARTE, Poliana Rodrigues Alves; FIDALE, Thiago Montes; CASELLA-FILHO, Antonio; DOURADO, Paulo Magno Martins; CHAGAS, Antonio Carlos Palandri; ALI-HASAN-AL-SAEGH, Sadeq; REIS, Paulo Eduardo Ocke; PINTO, Rogerio de Melo Costa; OLIVEIRA, Gustavo B. F.; AVEZUM, Alvaro; NETO, Mansueto; DURAES, Andre; SILVA, Rose Mary Ferreira Lisboa da; GRANDE, Antonio Jose; DENARDI, Celise; LOPES, Renato Delascio; NERLEKAR, Nitesh; ALIZADEH, Shahab; HERNANDEZ, Adrian V.; ROSA, Maria Ines da; BIONDI-ZOCCAI, GiuseppeBackground:Atherosclerosis is now widely recognized as a multifactorial disease with outcomes that arise from complex factors such as plaque components, blood flow, and inflammation. Epicardial adipose tissue (EAT) is a metabolically active fat depot, abundant in proinflammatory cytokines, and has been correlated with the extent and severity of carotid artery disease (CD). The locations most frequently affected by carotid atherosclerosis are the proximal internal carotid artery (ie, the origin) and the common carotid artery bifurcation. Progression of atheromatous plaque at the carotid bifurcation results in luminal narrowing, often accompanied by ulceration. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between EAT and CD. The aim of this study is to examine this association of EAT with CD in different ages and sex.Methods:This systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, Web of Science, and Google Scholar. Studies that (1) examined the association between EAT and CD, (2) focus on cohort, case-control and cross-sectional studies, (3) will conducted among in adults aged 40 to 70 years, (4) provided sufficient data for calculating ORs or relative risk with a 95% CI, (5) will published as original articles written in English or other languages, and (6) have been published until January 2018 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators.Results:We propose the current protocol to evaluate the evaluation of EAT with ED.Conclusion:This systematic review will not need ethical approval, because it does not involve human beings. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal.Ethics and dissemination:Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal.Trial registration number: PROSPERO (CRD42018083458).
- Metabolic syndrome and risk of stroke Protocol for an update systematic review and meta-analysis(2018) ROEVER, Leonardo; RESENDE, Elmiro Santos; DINIZ, Angelica Lemos Debs; PENHA-SILVA, Nilson; O'CONNELL, Joao Lucas; GOMES, Paulo Fernando Silva; ZANETTI, Hugo Ribeiro; ROERVER-BORGES, Anaisa Silva; VELOSO, Fernando Cesar; FIDALE, Thiago Montes; CASELLA-FILHO, Antonio; DOURADO, Paulo Magno Martins; CHAGAS, Antonio Carlos Palandri; ALI-HASAN-AL-SAEGH, Sadeq; REIS, Paulo Eduardo Ocke; PINTO, Rogerio de Melo; OLIVEIRA, Gustavo B. F.; AVEZUM, Alvaro; NETO, Mansueto; DURAES, Andre; SILVA, Rose Mary Ferreira Lisboa da; GRANDE, Antonio Jose; DENARDI, Celise; LOPES, Renato Delascio; NERLEKAR, Nitesh; ALIZADEH, Shahab; HERNANDEZ, Adrian V.; BIONDI-ZOCCAI, GiuseppeIntroduction: The metabolic syndrome is composed of several cardiovascular risk factors and has a high prevalence throughout the world. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between metabolic syndrome and stroke. The aim of this study is to examine this association of metabolic syndrome with stroke in different ages and sex. Methods and analysis: The update systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (i.e., PubMed, EMBASE, Web of Science, and Google Scholar. Studies that examined the association between metabolic syndrome and stroke, had a longitudinal or prospective cohort design, were conducted among in adults aged 40 to 70 years, provided sufficient data for calculating ORs or relative risk with a 95% CI, were published as original articles written in English or other languages, and have been published until December 2017 will be included. Study selection, data collection, quality assessment, and statistical syntheses will be conducted based on discussions among investigators. Ethics and dissemination: Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. The findings from this study could be useful for assessing metabolic syndrome risk factors in stroke, and determining approaches for prevention of stroke in the future.
- Abdominal Obesity and Association With Atherosclerosis Risk Factors(2016) ROEVER, Leonardo S.; RESENDE, Elmiro. S.; DINIZ, Angelica. L. D.; PENHA-SILVA, Nilson; VELOSO, Fernando C.; CASELLA-FILHO, Antonio; DOURADO, Paulo M. M.; CHAGAS, Antonio C. P.Ectopic visceral fat (VF) and subcutaneous fat (SCF) are associated with cardiovascular risk factors. Gender differences in the correlations of cardiovascular disease risk factors and ectopic fat in the Brazilian population still lacking. Cross-sectional study with 101 volunteers (50.49% men; mean age 56.5 +/- 18, range 19-74 years) drawn from the Uberlandia Heart Study underwent ultrasonography assessment of abdominal visceral adipose tissue with convex transducer of 3.5 MHz of frequency. The thickness of VF was ultrasonographically measured by the distance between the inner face of the abdominal muscle and the posterior face of abdominal aorta, 1 cm above the umbilicus. The SCF thickness was measured with a 7.5 MHz linear transducer transversely positioned 1 cm above the umbilical scar. The exams were always performed by the same examiner. Ectopic fat volumes were examined in relation to waist circumference, blood pressure, and metabolic risk factors. The VF was significantly associated with the levels of triglycerides (P < 0.01, r = 0.10), HDL cholesterol (P < 0.005, r = 0.15), total cholesterol (P < 0.01, r = 0.10), waist circumference (P < 0.0001, r = 0.43), systolic blood pressure (P < 0.001, r = 0.41), and diastolic blood pressure (P < 0.001, r = 0.32) in women, and with the levels of triglycerides (P < 0.002, r = 0,14), HDL cholesterol (P < 0.032, r = 0.07), glucose (P < 0.001, r = 0.15), alanine aminotransferase (ALT) (P < 0.008, r = 0.12), gamma-GT (P < 0.001, r = 0.30), waist circumference (P < 0.001, r = 0.52), systolic blood pressure (P < 0.001, r = 0.32), and diastolic blood pressure (P < 0.001, r = 0.26) in men. SCF was significantly associated with the levels of triglycerides (P < 0.01, r = 0.34), LDL cholesterol (P < 0.001, r = 0.36), total cholesterol (P < 0.05, r = 0.36), waist circumference (P < 0.0001, r = 0.62), systolic and diastolic blood pressure (P < 0.05, r = 0.34) in women, and with the waist circumference (P < 0.001, r = 0.065)), and MetS (P < 0.05, r = 0.11) in men. The VF and SCF were correlated with most cardiovascular risk factors in both genders but our findings support the idea that there are gender differences in the correlations between ectopic fat deposition and the cardiovascular risk factors.
- Perirenal Fat and Association With Metabolic Risk Factors The Uberlandia Heart Study(2015) ROEVER, Leonardo; RESENDE, Elmiro S.; VELOSO, Fernando C.; DINIZ, Angelica L. D.; PENHA-SILVA, Nilson; CASELLA-FILHO, Antonio; DOURADO, Paulo M. M.; CHAGAS, Antonio C. P.Perirenal fat (PRF) is associated with cardiovascular risk factors. Gender differences in the correlations of cardiovascular disease risk factors and PRF in the Brazilian population are lacking.Cross-sectional study with 101 (50.49% men; mean age 56.518, range 19-74 years) drawn from the Uberlandia Heart Study underwent ultrasonography assessment of abdominal adipose. For the PRF, a 3.5MHz transducer was measured in the middle third of the right kidney, with the transducer positioned at the axillary midline. The examinations were always performed by the same examiner. The PRF thickness was examined in relation to waist circumference, blood pressure, and metabolic risk factors. The PRF was significantly associated with the levels of gamma-glutamyl transferase (P<0.05, r=0.08), fasting plasma glucose (P<0.05, r=0.07), waist circumference (P<0.05, r=0.10), and metabolic syndrome (P<0.001, r=0.38) in men, and with the levels of fasting plasma glucose (P<0.05) in women.The PRF was correlated with most cardiovascular risk factors in men and only in glucose at the women.