ANDRE RONCON DIAS
Projetos de Pesquisa
Unidades Organizacionais
Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina - Médico
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
LIM/24 - Laboratório de Oncologia Experimental, Hospital das Clínicas, Faculdade de Medicina
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- Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review(2021) ZABOROWSKI, Alexandra M.; ABDILE, Ahmed; ADAMINA, Michel; AIGNER, Felix; D'ALLENS, Laura; ALLMER, Caterina; ALVAREZ, Andrea; ANULA, Rocio; ANDRIC, Mihailo; ATALLAH, Sam; BACH, Simon; FAES, Seraina; FAIZ, Omar; FLEMING, Fergal; FOPPA, Caterina; FOWLER, George; FRASSON, Matteo; FIGUEIREDO, Nuno; FORGAN, Tim; FRIZELLE, Frank; KRONBERGER, Irmgard; SCHNEIDER, Martin; GADAEV, Shamil; GELLONA, Jose; GLYN, Tamara; GONG, Jianping; GORAN, Barisic; GREENWOOD, Emma; GUREN, Marianne G.; GUILLON, Stephanie; GUTLIC, Ida; HAHNLOSER, Dieter; SEISHIMA, Ryo; KROON, Hidde Maarten; HAMPEL, Heather; HANLY, Ann; HASEGAWA, Hirotoshi; IVERSEN, Lene Hjerrild; HILL, Andrew; HILL, James; HOCH, Jiri; HOFFMEISTER, Michael; HOMPES, Roel; SEKULIC, Aleksandar; HURTADO, Luis; BALA, Miklosh; IAQUINANDI, Fabiano; IMBRASAITE, Ugne; ISLAM, Rumana; JAFARI, Mehrenah Dorna; KANEMITSU, Yukihide; KARACHUN, Aleksei; KARIMUDDIN, Ahmer A.; KELLER, Deborah S.; SEPPALA, Toni; KELLY, Justin; KENNELLY, Rory; KRYZAUSKAS, Marius; KHRYKOV, Gleb; KURAL, Said; KUSTERS, Miranda; LAKKIS, Zaher; LANKOV, Timur; LARSON, Dave; LAZAR, Gyorgy; SHEAHAN, Kieran; LEE, Kai-Yin; LEE, Suk Hwan; LEFEVRE, Jeremie H.; BARUSSAUD, Marie; LEPISTO, Anna; LIEU, Christopher; LOI, Lynette; LYNCH, Craig; MAILLOU-MARTINAUD, Helene; MAROLI, Annalisa; SHINE, Rebecca; MARTIN, Sean; MARTLING, Anna; MATZEL, Klaus E.; MAYOL, Julio; BAUSYS, Augustinas; MCDERMOTT, Frank; MEURETTE, Guillaume; MILLAN, Monica; MITTEREGGER, Martin; MOISEENKO, Andrei; SHLOMINA, Alexandra; MONSON, John R. T.; MORARASU, Stefan; MORITANI, Konosuke; MOSLEIN, Gabriela; MUNINI, Martino; BEBINGTON, Brendan; NAHAS, Caio; NAHAS, Sergio; NEGOI, Ionut; NOVIKOVA, Anastasia; SICA, Guiseppe S.; OCARES, Misael; OKABAYASHI, Koji; OLKINA, Alexandra; ONATE-OCANA, Luis; OTERO, Jaime; OZEN, Cihan; BEGGS, Andrew; PACE, Ugo; JULIAO, Guilherme Pagin Sao; PANAIOTTI, Lidiia; SINGNOMKLAO, Tongplaew; PANIS, Yves; PAPAMICHAEL, Demetris; PARK, Jason; PATEL, Swati; URIBURU, Juan Carlos Patron; PERA, Miguel; PEREZ, Rodrigo O.; BELLOLIO, Felipe; PETROV, Alexei; PFEFFER, Frank; BEVAN, Vicki; PHANG, P. Terry; POSKUS, Tomas; PRINGLE, Heather; PROUD, David; RAGUZ, Ivana; RAMA, Nuno; RASHEED, Shahnawaz; RAVAL, Manoj J.; BENNETT, Melissa-Rose; REGA, Daniela; KOCIAN, Peter; REISSFELDER, Christoph; MENESES, Juan Carlos Reyes; RIS, Frederic; RISS, Stefan; RODRIGUEZ-ZENTNER, Homero; ROXBURGH, Campbell S.; SAKLANI, Avanish; SALIDO, Andrea Jimenez; SAMMOUR, Tarik; BERDINSKIKH, Anton; SIRAGUSA, Leandro; SARASTE, Deborah; SMART, Neil; SOLIS, Alejandro; SPINELLI, Antonino; STAIGER, Roxane D.; STAMOS, Michael J.; STEELE, Scott; SUNDERLAND, Michael; TAN, Ker-Kan; TANIS, Pieter J.; KOH, Cherry; BIONDO, Sebastiano; TEKKIS, Paris; TEKLAY, Biniam; TENGKU, Sabrina; JIMENEZ-TOSCANO, Marta; TSARKOV, Petr; TURINA, Matthias; ULRICH, Alexis; VAILATI, Bruna B.; HARTEN, Meike van; KOK, Neils; VERHOEF, Cornelis; BISLENGHI, Gabriele; WARRIER, Satish; WEXNER, Steve; WILT, Hans de; WEINBERG, Benjamin A.; WELLS, Cameron; WOLTHUIS, Albert; XYNOS, Evangelos; YOU, Nancy; KNIGHT, Katrina A.; ZAKHARENKO, Alexander; ZEBALLOS, Justino; BLUDAU, Marc; WINTER, Des C.; BOUTALL, Adam; BROUWER, Nelleke; BROWN, Carl; BRUNS, Christiane; BUCHANAN, Daniel D.; BUCHWALD, Pamela; KNOL, Joep; BURGER, Jacobus W. A.; BURLOV, Nikita; CAMPANELLI, Michela; CAPDEPONT, Maylis; CARVELLO, Michele; CHEW, Hwee-Hoon; CHRISTOFORIDIS, Dimitri; CLARK, David; CLIMENT, Marta; COLOGNE, Kyle G.; KONTOVOUNISIOS, Christos; CONTRERAS, Tomas; CRONER, Roland; DANIELS, Ian R.; DAPRI, Giovanni; DAVIES, Justin; DELRIO, Paolo; DENOST, Quentin; DEUTSCH, Michael; DIAS, Andre; D'HOORE, Andre; KORNER, Hartwig; DROZDOV, Evgeniy; DUEK, Daniel; DUNLOP, Malcolm; DZIKI, Adam; EDMUNDSON, Aleksandra; EFETOV, Sergey; EL-HUSSUNA, Alaa; ELLIOT, Brodie; EMILE, Sameh; ESPIN, Eloy; KRIVOKAPIC, Zoran; EVANS, MartynIMPORTANCE The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. OBSERVATIONS Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include aWesternized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. CONCLUSIONS AND RELEVANCE The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.
- BRAZILIAN GASTRIC CANCER ASSOCIATION GUIDELINES (PART 2): UPDATE ON TREATMENT(2021) BARCHI, Leandro Cardoso; RAMOS, Marcus Fernando Kodama Pertille; DIAS, Andre Roncon; FORONES, Nora Manoukian; CARVALHO, Marineide Prudencio de; CASTRO, Osvaldo Antonio Prado; KASSAB, Paulo; COSTA-JUNIOR, Wilson Luiz da; WESTON, Antonio Carlos; ZILBERSTEIN, BrunoBackground: The II Brazilian Consensus on Gastric Cancer of the Brazilian Gastric Cancer Association BGCA (Part 1) was recently published. On this occasion, countless specialists working in the treatment of this disease expressed their opinion in the face of the statements presented. Aim: To present the BGCA Guidelines (Part 2) regarding indications for surgical treatment, operative techniques, extension of resection and multimodal treatment. Methods: To formulate these guidelines, the authors carried out an extensive and current review regarding each declaration present in the II Consensus, using the Medline/PubMed, Cochrane Library and SciELO databases initially with the following descriptors: gastric cancer, gastrectomy, lymphadenectomy, multimodal treatment. In addition, each statement was classified according to the level of evidence and degree of recommendation. Results: Of the 43 statements present in this study, 11 (25,6%) were classified with level of evidence A, 20 (46,5%) B and 12 (27,9%) C. Regarding the degree of recommendation, 18 (41,9%) statements obtained grade of recommendation 1, 14 (32,6%) 2a, 10 (23,3%) 2b e one (2,3%) 3. Conclusion: The guidelines complement of the guidelines presented here allows surgeons and oncologists who work to combat gastric cancer to offer the best possible treatment, according to the local conditions available.