EDUARDO FERREIRA BORBA NETO
Projetos de Pesquisa
Unidades Organizacionais
Departamento de Clínica Médica, Faculdade de Medicina - Docente
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
LIM/17 - Laboratório de Investigação em Reumatologia, Hospital das Clínicas, Faculdade de Medicina
16 resultados
Resultados de Busca
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- Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus(2023) AIKAWA, Nadia Emi; BORBA, Eduardo Ferreira; BALBI, Verena Andrade; SALLUM, Adriana Maluf Elias; BUSCATTI, Izabel Mantovani; CAMPOS, Lucia Maria Arruda; KOZU, Katia Tomie; GARCIA, Cristiana Couto; CAPAO, Artur Silva Vidal; PROENCA, Adriana Coracini Tonacio de; LEON, Elaine Pires; DUARTE, Alberto Jose da Silva; LOPES, Marta Heloisa; SILVA, Clovis Artur; BONFA, EloisaIntroduction Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1. Data assessing immunogenicity and safety of this virus component in juvenile systemic lupus erythematosus (JSLE) is lacking in the literature.Objective To evaluate short-term immunogenicity and safety of influenza A/Singapore (H3N2) vaccine in JSLE.Methods 24 consecutive JSLE patients and 29 healthy controls (HC) were vaccinated with influenza A/Singapore/INFIMH-16-0019/2016(H3N2)-like virus. Influenza A (H3N2) seroprotection (SP), seroconversion (SC), geometric mean titers (GMT), factor increase in GMT (FI-GMT) titers were assessed before and 4 weeks post-vaccination. Disease activity, therapies and adverse events (AE) were also evaluated.Results JSLE patients and controls were comparable in current age [14.5 (10.1-18.3) vs. 14 (9-18.4) years, p = 0.448] and female sex [21 (87.5%) vs. 19 (65.5%), p = 0.108]. Before vaccination, JSLE and HC had comparable SP rates [22 (91.7%) vs. 25 (86.2%), p = 0.678] and GMT titers [102.3 (95% CI 75.0-139.4) vs. 109.6 (95% CI 68.2-176.2), p = 0.231]. At D30, JSLE and HC had similar immune response, since no differences were observed in SP [24 (100%) vs. 28 (96.6%), p = 1.000)], SC [4 (16.7%) vs. 9 (31.0%), p = 0.338), GMT [162.3 (132.9-198.3) vs. 208.1 (150.5-287.8), p = 0.143] and factor increase in GMT [1.6 (1.2-2.1) vs. 1.9 (1.4-2.5), p = 0.574]. SLEDAI-2K scores [2 (0-17) vs. 2 (0-17), p = 0.765] and therapies remained stable throughout the study. Further analysis of possible factors influencing vaccine immune response among JSLE patients demonstrated similar GMT between patients with SLEDAI < 4 compared to SLEDAI >= 4 (p = 0.713), as well as between patients with and without current use of prednisone (p = 0.420), azathioprine (p = 1.0), mycophenolate mofetil (p = 0.185), and methotrexate (p = 0.095). No serious AE were reported in both groups and most of them were asymptomatic (58.3% vs. 44.8%, p = 0.958). Local and systemic AE were alike in both groups (p > 0.05).Conclusion This is the first study that identified adequate immune protection against H3N2-influenza strain with additional vaccine-induced increment of immune response and an adequate safety profile in JSLE. (www.clinicaltrials.gov, NCT03540823).
conferenceObject BASELINE CHARACTERISTICS OFA LONGITUDINAL, MULTINATIONAL, MULTIETHNIC STUDYOF LUPUS PATIENTS, WITH ORWITHOUT LUPUS NEPHRITIS(2023) NIETO, Romina; QUINTANA, Rosana; BORBA, Eduardo; HERNANDEZ, Lucia; FERNANDEZ, Diana; MAURELLI, Laura; ALBA, Paula; BORDON, Florencia; ARIZPE, Fernando; BERBOTTO, Guillermo; SERRANO, Rosa; BERTOLACCINI, Maria; KERSBERG, Eduardo; GARGIULO, Maria; RODRIGUEZ, Anabella; BARBOSA, Vitalina; GASPARIN, Andrese; CAVALCANTI, Fernando; ALVES, Laissa; PARENTE, Luciana; OLIVEIRA, Lucas de; NEIRA, Oscar; MASSARDO, Loreto; AROCA, Gustavo; NIETO, Ivana; MENDEZ, Paul; IGLESIAS, Antonio; ZUNIGA, Andres; VERA, Olga; PEREZ, Mario; NARES, Eduardo; AMEZCUA, Luis; GONZALEZ, Yelitza; GONZALEZ, Octavio; GALARZA, Dionicio; VAZQUEZ, Carolina; BARRIOS, Marcelo; LINARES, Magaly; REATEGUI, Cristina; QUIROS, Ana; POLANCO, Teresandris; PIZZAROSSA, Carina; REBELLA, Martin; CRESPO, Maria; DANZA, Alvaro; BONFA, Eloisa; ALARCON, Graciela; ZAZZETTI, Federico; ORILLION, Ashley; SBARIGIA, Urbano; ESTEL, Guillermo Pons- Bone erosions associated with systemic bone loss on HR-pQCT in women with longstanding polyarticular juvenile idiopathic arthritis(2023) RIBEIRO, Surian Clarisse C. R.; SALES, Lucas P.; FERNANDES, Alan L.; PEREZ, Mariana O.; TAKAYAMA, Liliam; CAPARBO, Valeria F.; ASSAD, Ana Paula L.; AIWAKA, Nadia E.; GOLDENSTEIN-SCHAINBERG, Claudia; BORBA, Eduardo F.; DOMICIANO, Diogo S.; FIGUEIREDO, Camille P.; PEREIRA, Rosa M. R.Objectives: To analyze longstanding polyarticular juvenile idiopathic arthritis (pJIA) for possible associations between localized bone damage (erosions), and systemic bone loss. Besides, to compare the systemic bone mass of pJIA with healthy controls. Methods: Thirty-four pJIA women and 99 healthy controls (HC) were included. Radius and tibia of all subjects were scanned by HR-pQCT. Volumetric bone mineral density (vBMD), bone microarchitecture, and -finite element parameters were analyzed. Patients underwent HR-pQCT of 2nd and 3rd metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints of the dominant hand, for bone erosions quantification. Results: The mean age of patients was 31.5 +/- 7.4yrs with a mean disease duration of 21.7 +/- 9.2yrs. Bone erosions were detectable in 79% of patients. The number of bone erosions was positively correlated with cortical porosity (Ct.Po) at tibia (r = 0.575, p = 0.001), and radius (r = 0.423, p = 0.018); and negatively correlated with cortical vBMD at tibia (r=-0.420, p = 0.015). In a logistic regression analysis, adjusted for anti-CCP, the presence of bone erosions was independently associated with Ct.Po at radius (p = 0.018) and cortical vBMD at tibia (p = 0.020). Moreover, cortical and trabecular vBMD, trabecular number, and mu-finite element parameters were decreased in patients compared to HC (p < 0.05). Conclusion: Bone erosions in longstanding pJIA women were associated with decreased cortical bone parameters, and these patients showed systemic bone impairment at peripheral sites compared with healthy controls.
conferenceObject PREGNANCYOUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS: DATA FROM A MULTIETHNIC, MULTINATIONAL LATIN AMERICAN COHORT(2023) MORALES, Rosa M. Serrano; NIETO, Romina; QUINTANA, Rosana; ALBA, Paula; PORTA, Sabrina; HERNANDEZ, Lucia; BERBOTTO, Guillermo A.; BELLOMIO, Veronica; SILVA, Nilzio A. da; MONTICIELO, Odirlei Andre; CAVALCANTI, Fernando S.; RIBEIRO, Francinne Machado; BORBA, Eduardo F.; BONFA, Eloisa; MASSARDO, Loreto; MARTINEZ, Gustavo Aroca; BONFANTI, Andres Cadena; LOPEZ, Gerardo Quintana; MORENO, Mario; VALERIO, Jorge A. Esquivel; COLMAN, Maria I. Acosta; NICORA, Astrid Paats; TRUJILLO, Claudia S. Mora; SCOLNIK, Marina; FERNANDEZ, Diana; SOAJE, Carmen Funes; SAURIT, Veronica; GARCIA, Mercedes; KERZBERG, Eduardo; GOMEZ, Graciela; PISONI, Cecilia; REIS NETO, Edgard Torres dos; HERRERA, Iris Guerra; QUIROGA, Oscar Neira; CANAS, Carlos A.; SALINAS, Miguel A. Saavedra; HERNANDEZ, Margarita Portela; LOYO, Hilda Fragoso; SILVEIRA, Luis H.; UGARTE-GIL, Manuel; QUIROZ, Armando Calvo; LOUIS, Roberto Munoz; ROBAINA, Ricardo; JUAREZ, Vicente; DANZA, Alvaro; TORO-GUTIERREZ, Carlos E.; MENDOZA, Carlos Abud; MALVAR, Ana; ALARCON, Graciela S.; ORILLION, Ashley; SBARIGIA, Urbano; ZAZZETTI, Federico; PONS-ESTEL, Guillermo J.; PONS-ESTEL, Bernardo A.- Short-term Accrual 2019 European League Against Rheumatism/American College of Rheumatology Domains and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage in Lupus Patients With and Without Nephritis at Disease Onset(2023) MUNHOZ, Gabriela A.; AIKAWA, Nadia E.; SILVA, Clovis A.; PASOTO, Sandra G.; PEDROSA, Tatiana N.; SEGURO, Luciana P. C.; BONFA, Eloisa; BORBA, Eduardo F.ObjectiveTo determine in a historical inception cohort the impact of lupus nephritis at disease onset in short-term accrual 2019 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) domains. The possible association with treatment and damage was also investigated.MethodsOne hundred thirty-three consecutive adult systemic lupus erythematosus patients according to the 2019 EULAR/ACR criteria were divided according to the presence (RENAL-lupus) or absence of renal involvement (NONRENAL-lupus) at disease onset. The 2019 EULAR/ACR score and Systemic Lupus International Collaborating Clinics/ACR (SDI) were longitudinally evaluated over 3 years.ResultsRENAL-lupus (n = 49 [36.8%]) and NONRENAL-lupus (n = 84 [63.2%]) were similar regarding age (p = 0.704), female sex (p = 0.313), and black race (p = 0.506). At study entry, RENAL-lupus had higher 2019 EULAR/ACR total domains (30 [12-42] vs. 22 [10-36], p < 0.001) and used more often glucocorticoid (p < 0.001), mycophenolate mofetil (p = 0.007), and cyclophosphamide (p = 0.001). After 3 years, a stable number of domain scores was observed for the RENAL-lupus (30 [12-42] vs. 30 [12-42], p = 0.125), whereas an increase was observed for the NONRENAL-lupus (22 [10-36] vs. 23 [10-40], p < 0.001) compared with baseline. Accordingly, RENAL-lupus patients had a lower frequency of additional domains (3/49 [6.1%] vs. 37/84 [44.0%], p < 0.0001). New kidney involvement occurred in 15 (44.1%) of 34 patients of the NONRENAL-lupus. Both groups evolved with a comparable increase in frequency of patients with damage (SDI >= 1) at the end of the study (23/49 [46.9%] vs. 34/89 [40.54%], p = 0.585) with a similar median of SDI (1 [0-4] vs. 0 [0-2], p = 0.132).ConclusionsThe distinct pattern of accrual 2019 EULAR/ACR domains in patients with and without nephritis at disease onset suggests that close surveillance for additional organ involvement, including kidney, is mandatory in NONRENAL lupus in the first 3 years of disease. The unexpected comparable early damage in both groups despite milder disease and less intense immunosuppression in NONRENAL lupus reinforces the need for new and tailored therapies for these patients.
- Transcriptomic characterization of classical monocytes highlights the involvement of immuno-inflammation in bone erosion in Rheumatoid Arthritis(2023) SALES, Lucas Peixoto; HOUNKPE, Bidossessi Wilfried; PEREZ, Mariana Ortega; CAPARBO, Valeria Falco; DOMICIANO, Diogo Souza; BORBA, Eduardo Ferreira; SCHETT, Georg; FIGUEIREDO, Camille Pinto; PEREIRA, Rosa Maria RodriguesIntroduction: Evidence-based data suggest that under inflammatory conditions, classical monocytes are the main source of osteoclasts and might be involved in bone erosion pathophysiology. Here, we analyze the transcriptomic profile of classical monocytes in erosive and non-erosive rheumatoid arthritis patients in order to better understand their contribution to bone erosion.Methods: Thirty-nine premenopausal RA patients were consecutively enrolled and divided into two groups based on the presence of bone erosions on hand joints. Classical monocytes were isolated from peripheral blood through negative selection, and RNA-seq was performed using a poly-A enrichment kit and Illumina (R) platform. Classical monocytes transcriptome from healthy age-matched women were also included to identify differentially expressed genes (DEGs). Therefore, gene sets analysis was performed to identify the enriched biological pathways.Results: RNA-seq analysis resulted in the identification of 1,140 DEGs of which 89 were up-regulated and 1,051 down-regulated in RA patients with bone erosion compared to those without bone erosions. Among up-regulated genes, there was a highlighted expression of IL18RAP and KLF14 related to the production of pro-inflammatory cytokines, innate and adaptive immune response. Genes related to collagen metabolism (LARP6) and bone formation process (PAPPA) were down-regulated in RA patients with erosions. Enriched pathways in patients with erosions were associated with greater activation of immune activation, and inflammation. Interestingly, pathways associated with osteoblast differentiation and regulation of Wnt signaling were less activated in RA patients with erosions.Conclusion: These findings suggest that alterations in expression of monocyte genes related to the inflammatory process and impairment of bone formation might have an important role in the pathophysiology of bone erosions in RA patients.
- RNA-SEQUENCING OF CLASSICAL MONOCYTES FROM RHEUMATOID ARTHRITIS PATIENTS WITH AND WITHOUT BONE EROSION(2023) SALES, L. Peixoto; HOUNKPE, B.; PEREZ, M.; CAPARBO, V.; DOMICIANO, D. S.; BORBA, E.; FIGUEIREDO, C.; PEREIRA, R. M.
- PREDICTORS OF FIRST HOSPITALIZATIONS DUE TO DISEASE ACTIVITY AND INFECTIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS(2023) QUINTANA, R.; NIETO, R.; MORALES, R. Serrano; UGARTE-GIL, M. F.; HARVEY, G. B.; WOJDYLA, D.; GOMEZ-PUERTA, J. A.; GARCIA, M.; CATOGGIO, L.; SAURIT, V.; DRENKARD, C.; SILVA, N. Da; CAVALCANTI, F.; BORBA, E.; SATO, E.; NEIRA, O.; MASSARDO, L.; VASQUEZ, G.; GONZALEZ, L. A.; GUIBERT-TOLEDANO, M.; TORRE, L. H. Silveira; TORRE, I. Garcia-De La; POZO, M. J. Sauza Del; CHACON, R.; ALARCON, G. S.; ORILLION, A.; SBARIGIA, U.; ZAZZETTI, F.; PONS-ESTEL, B.; PONS-ESTEL, G.
conferenceObject MALE SEX AND DISEASE ACTIVITYAT DIAGNOSIS ARE PREDICTORS OF SEVERE HEMOLYTIC ANEMIA IN PATIENTSWITH SYSTEMIC LUPUS ERYTHEMATOSUS: DATA FROM A MULTIETHNIC LATIN AMERICAN COHORT(2023) GONZALEZ, Luis A.; ALARCON, Graciela S.; HARVEY, Guillermina B.; QUINTANA, Rosana; PONS-ESTEL, Guillermo J.; UGARTE-GIL, Manuel F.; VASQUEZ, Gloria; CATOGGIO, Luis J.; GARCIA, Mercedes A.; BORBA, Eduardo F.- PREGNANCY OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): DATA FROM A MULTIETHNIC, MULTINATIONAL LATIN AMERICAN COHORT(2023) MORALES, R. M. Serrano; NIETO, R.; QUINTANA, R.; ALBA, P.; PORTA, S.; HERNANDEZ, L.; BERBOTTO, G.; BELLOMIO, V. I.; SILVA, N. Da; MONTICIELO, O.; CAVALCANTI, F.; RIBEIRO, F. Machado; BORBA, E.; BONFA, E.; MASSARDO, L.; MARTINEZ, G. Aroca; BONFANTI, A. Cadena; LOPEZ, G. Quintana; ALVAREZ, M. J. Moreno; VALERIO, J. A. Esquivel; ACOSTA-COLMAN, I.; PAATS, A.; MORA, C.; SCOLNIK, M.; AVILA, D. Fernandez; SOAJE, C. Funes; SAURIT, V.; GARCIA, M.; KERZBERG, E.; GOMEZ, G.; PISONI, C.; REIS NETO, E.; HERRERA, I. Guerra; NEIRA, O.; CANAS, C.; SAAVEDRA, M. A.; PORTELA, M.; LOYO, H. Fragoso; TORRE, L. H. Silveira; TORRE, I. Garcia-De la; UGARTE-GIL, M. F.; QUIROZ, A. Calvo; LOUIS, R. Munoz; ROBAINA, R.; JUAREZ, V.; DANZA, A.; GUTIERREZ, C. E. Toro; ABUD-MENDOZA, C.; MALVAR, A.; ALARCON, G. S.; ORILLION, A.; SBARIGIA, U.; ZAZZETTI, F.; PONS-ESTEL, G.; PONS-ESTEL, B.