Frequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, Marianges Zadrozny Gouvea da
dc.contributor.authorPIRES, Julia Gloria Lucatelli
dc.contributor.authorNASSER, Paulo Dominguez
dc.contributor.authorFERREIRA, Camila da Silva
dc.contributor.authorTEIXEIRA, Ana Cristina de Sa
dc.contributor.authorPARANAGUA-VEZOZZO, Denise Cerqueira
dc.contributor.authorGUARITA, Dulce Reis
dc.contributor.authorCARRILHO, Flair Jose
dc.contributor.authorONO, Suzane Kioko
dc.date.accessioned2016-12-20T16:37:48Z
dc.date.available2016-12-20T16:37:48Z
dc.date.issued2016
dc.description.abstractObjective: This study aimed to investigate the association between chronic pancreatitis and smoking or genetic mutations. Methods: The study sample comprised 148 patients with chronic pancreatitis, 110 chronic alcoholic subjects without pancreatic disease, and 297 volunteer blood donors. Results: Of the patients with chronic pancreatitis, 74% had alcoholic etiology and 26% had idiopathic pancreatitis. The frequency of smoking was 91.4% in patients with alcoholic pancreatitis, higher than 73.3% in alcoholic subjects without pancreatitis (P < 0.01). The difference in smoking frequency was not significant between the patients with idiopathic pancreatitis and blood donors. The N34S mutation of serine peptidase inhibitor, Kazal type 1 (SPINK1) was found in 2.7% of patients with chronic alcoholic pancreatitis, in 5.3% of patients with idiopathic pancreatitis, and in 0.4% of blood donors (P = 0.02). The P55S mutation of SPINK1 was found in 2.7% of patients with alcoholic pancreatitis and in 0.7% of blood donors (P = 0.12). The R254W mutation of chymotrypsin C was found in 0.9% of patients with alcoholic pancreatitis, in 0.9% of chronic alcoholic subjects without pancreatitis, and in 0.4% of blood donors (P = 0.75). In all cases, the mutations were heterozygous. Conclusions: Smoking and the N34S mutation of SPINK1 were positively correlated with chronic pancreatitis.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipComissao de Aperfeicoamento de Pessoal do Nivel Superior (CAPES)
dc.description.sponsorshipAlves de Queiroz Family Fund for Research
dc.identifier.citationPANCREAS, v.45, n.9, p.1330-1335, 2016
dc.identifier.doi10.1097/MPA.0000000000000650
dc.identifier.eissn1536-4828
dc.identifier.issn0885-3177
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17079
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofPancreas
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectepidemiology
dc.subjectetiology
dc.subjectchronic pancreatitis
dc.subjectgenetics
dc.subjectsmoking
dc.subject.othercigarette-smoking
dc.subject.otherprotease inhibitor
dc.subject.otherrisk-factor
dc.subject.othergene
dc.subject.othernationwide
dc.subject.othercancer
dc.subject.otherclassification
dc.subject.otherepidemiology
dc.subject.otherassociation
dc.subject.otherprevalence
dc.subject.wosGastroenterology & Hepatology
dc.titleFrequency of Tabagism and N34S and P55S Mutations of Serine Peptidase Inhibitor, Kazal Type 1 (SPINK1) and R254W Mutation of Chymotrypsin C (CTRC) in Patients With Chronic Pancreatitis and Controls
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalGUARITA, Dulce Reis:Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo, Brazil
hcfmusp.citation.scopus4
hcfmusp.contributor.author-fmusphcMARIANGES ZADROZNY GOUVEA DA COSTA
hcfmusp.contributor.author-fmusphcJULIA GLORIA LUCATELLI PIRES
hcfmusp.contributor.author-fmusphcPAULO DOMINGUEZ NASSER
hcfmusp.contributor.author-fmusphcCAMILA DA SILVA FERREIRA
hcfmusp.contributor.author-fmusphcANA CRISTINA DE SA TEIXEIRA
hcfmusp.contributor.author-fmusphcDENISE CERQUEIRA PARANAGUA VEZOZZO
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.contributor.author-fmusphcSUZANE KIOKO ONO
hcfmusp.description.beginpage1330
hcfmusp.description.endpage1335
hcfmusp.description.issue9
hcfmusp.description.volume45
hcfmusp.origemWOS
hcfmusp.origem.pubmed27776049
hcfmusp.origem.scopus2-s2.0-84973131607
hcfmusp.origem.wosWOS:000384112900018
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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