Influence of the C242T Polymorphism of the p22-phox Gene (CYBA) on the Interaction between Urinary Sodium Excretion and Blood Pressure in an Urban Brazilian Population

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSCHREIBER, Roberto
dc.contributor.authorBELLINAZZI, Vera Regina
dc.contributor.authorSPOSITO, Andrei C.
dc.contributor.authorMILL, Jose G.
dc.contributor.authorKRIEGER, Jose E.
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorNADRUZ JR., Wilson
dc.date.accessioned2014-04-25T21:50:39Z
dc.date.available2014-04-25T21:50:39Z
dc.date.issued2013
dc.description.abstractBackground: Reactive oxygen species are implicated in the physiopathogenesis of salt-induced hypertension and the C242T polymorphism of the p22-phox gene has been associated with higher superoxide production. This study investigated the impact of this polymorphism on the relationship between urinary sodium excretion (USE) and blood pressure levels in an urban Brazilian population. Methods: We cross-sectionally evaluated 1,298 subjects from the city of Vitoria-ES, located in the Southeast region of Brazil, by clinical history, physical examination, anthropometry, analysis of laboratory parameters, USE measurement and p22-phox C242T polymorphism genotyping. Results: No significant differences in studied parameters were detected between the studied genotype groups (CC vs. CT+TT). Systolic blood pressure exhibited significant correlation with USE only in T allele carriers (r = 0.166; p<0.001), while diastolic blood pressure and hypertension status correlated with USE in both genotypes albeit more weakly in subjects with CC genotype (r=0.098; p=0.021 and r=0.105; p=0.013, respectively) than in T carriers (r=0.236; p<0.001 and r=0.213; p<0.001, respectively). Regression analyses adjusted for confounding factors showed that USE remained independently associated with systolic (p<0.001) and diastolic blood pressure (p<0.001) and hypertension status (p = 0.004) only in T allele carriers. Finally, higher diastolic and systolic blood pressure levels were detected in T allele carriers than in CC genotype individuals in the highest tertile of USE. Conclusions: The p22-phox 242T allele is associated with higher blood pressure levels among subjects with higher USE in an urban Brazilian population.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP [2010/16252-0]
dc.description.sponsorshipCNPq, Brazil [476909/2012-0, 303539/2010-0]
dc.identifier.citationPLOS ONE, v.8, n.12, article ID e81054, 5p, 2013
dc.identifier.doi10.1371/journal.pone.0081054
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5105
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.othernadph oxidase
dc.subject.otherhypertensive patients
dc.subject.othersalt sensitivity
dc.subject.otheroxidative stress
dc.subject.otherassociation
dc.subject.otherp22(phox)
dc.subject.otheratherosclerosis
dc.subject.otherp22phox
dc.subject.otherdisease
dc.subject.othersystem
dc.subject.wosMultidisciplinary Sciences
dc.titleInfluence of the C242T Polymorphism of the p22-phox Gene (CYBA) on the Interaction between Urinary Sodium Excretion and Blood Pressure in an Urban Brazilian Population
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSCHREIBER, Roberto:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalBELLINAZZI, Vera Regina:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalSPOSITO, Andrei C.:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.author.externalMILL, Jose G.:Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, Brazil
hcfmusp.author.externalNADRUZ JR., Wilson:Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil
hcfmusp.citation.scopus5
hcfmusp.contributor.author-fmusphcJOSE EDUARDO KRIEGER
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.description.articlenumbere81054
hcfmusp.description.issue12
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed24339896
hcfmusp.origem.scopus2-s2.0-84891954874
hcfmusp.origem.wosWOS:000328566100030
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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hcfmusp.remissive.sponsorshipCNPq
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