Absence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma variant

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVILLAS-BOAS, Lucy Santos
dc.contributor.authorPAULA, Anderson Vicente de
dc.contributor.authorSILVA, Almir Ribeiro da
dc.contributor.authorPAIAO, Heuder Gustavo Oliveira
dc.contributor.authorTOZETTO-MENDOZA, Tania Regina
dc.contributor.authorMANULI, Erika Regina
dc.contributor.authorLEAL, Fabio Eudes
dc.contributor.authorFERRAZ, Andrea de Barros Coscelli
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorBIERRENBACH, Ana Luiza
dc.contributor.authorWITKIN, Steven Sol
dc.contributor.authorMENDES-CORREA, Maria Cassia
dc.date.accessioned2022-10-26T14:27:08Z
dc.date.available2022-10-26T14:27:08Z
dc.date.issued2022
dc.description.abstractObjectives: The aim of the present study was to evaluate if neutralizing antibody responses induced by infection with the SARS-CoV-2 strain that was dominant at the beginning of the pandemic or by the Gamma variant was effective against the Omicron variant. Methods: Convalescent sera from 109 individuals, never exposed to a SARS-CoV-2 vaccine, who had mild or moderate symptoms not requiring hospitalization following either a documented SARS-CoV-2 ancestral strain infection or a Gamma variant infection, were assayed for in vitro neutralizing antibody activity against their original strains and the Omicron variant. Results: Following an infection with the ancestral strain, 56 (93.3%), 45 (77.6%) and 1 (1.7%) serum sample were positive for neutralizing antibodies against the ancestral, Gamma variant, and Omicron variant, respectively. After infection with the Gamma variant, 43 (87.8%) and 2 (4.1%) sera were positive for neutralizing antibodies against the Gamma and Omicron variants, respectively. Conclusions: Neutralizing antibodies generated following mild or moderate infection with the SARS-CoV-2 ancestral strain or the Gamma variant are not protective against the Omicron variant.eng
dc.description.indexMEDLINEeng
dc.identifier.citationCLINICS, v.77, article ID 100068, 4p, 2022
dc.identifier.doi10.1016/j.clinsp.2022.100068
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/49242
dc.language.isoeng
dc.publisherELSEVIER ESPANAeng
dc.relation.ispartofClinics
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER ESPANAeng
dc.subjectSARS-CoV-2eng
dc.subjectOmicron varianteng
dc.subjectGamma varianteng
dc.subjectNeutralizing antibodieseng
dc.subjectProtective antibodieseng
dc.subject.wosMedicine, General & Internaleng
dc.titleAbsence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma varianteng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalLEAL, Fabio Eudes:Fac Med Univ Municipal Sao Caetano do Sul, Sao Caetano, Sao Caetano do Sul, SP, Brazil
hcfmusp.author.externalFERRAZ, Andrea de Barros Coscelli:Fac Med Univ Municipal Sao Caetano do Sul, Sao Caetano, Sao Caetano do Sul, SP, Brazil
hcfmusp.author.externalBIERRENBACH, Ana Luiza:Inst Ensino & Pesquisa Hosp Sirio Libanes, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcLUCY SANTOS VILAS BOAS
hcfmusp.contributor.author-fmusphcANDERSON VICENTE DE PAULA
hcfmusp.contributor.author-fmusphcALMIR RIBEIRO DA SILVA JUNIOR
hcfmusp.contributor.author-fmusphcHEUDER GUSTAVO OLIVEIRA PAIAO
hcfmusp.contributor.author-fmusphcTANIA REGINA TOZETTO MENDOZA
hcfmusp.contributor.author-fmusphcERIKA REGINA MANULI
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.contributor.author-fmusphcSTEVEN SOL WITKIN
hcfmusp.contributor.author-fmusphcMARIA CASSIA JACINTHO MENDES CORREA
hcfmusp.description.articlenumber100068
hcfmusp.description.volume77
hcfmusp.origemWOS
hcfmusp.origem.pubmed35767900
hcfmusp.origem.scieloSCIELO:S1807-59322022000100242
hcfmusp.origem.scopus2-s2.0-85132917037
hcfmusp.origem.wosWOS:000834114100002
hcfmusp.publisher.cityMADRIDeng
hcfmusp.publisher.countrySPAINeng
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hcfmusp.scopus.lastupdate2024-05-10
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