Vitamin A and Beta-Carotene Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKAIO, Daniella Junko
dc.contributor.authorRONDO, Patricia Helen Carvalho
dc.contributor.authorSOUZA, Jose Maria Pacheco
dc.contributor.authorFIRMINO, Aline Vale
dc.contributor.authorLUZIA, Liania Alves
dc.contributor.authorSEGURADO, Aluisio Augusto
dc.date.accessioned2014-04-25T21:51:51Z
dc.date.available2014-04-25T21:51:51Z
dc.date.issued2013
dc.description.abstractMicronutrient deficiency is a common condition in HIV-infected individuals and may occur in all stages of the disease. The objective of this cross-sectional study was to compare the concentrations of vitamin A and beta-carotene, micronutrients related to immunity and oxidative stress, in 182 adults with HIV/AIDS, under different highly active antiretroviral therapy (HAART) regimens. Patients were divided into 3 groups according to their HAART regimen: combination of nucleoside analog reverse transcriptase inhibitors (NRTIs) and non-NRTIs; combination of NRTIs, protease inhibitors, and ritonavir; combination of NRTIs and other classes. Multiple linear regression analysis determined the effect of the treatment regimen, time of use, and compliance with the regimen, on vitamin A and beta-carotene concentrations, controlling for the following variables: gender, age, educational level, smoking, physical activity, body mass index, time of infection with HIV, presence of comorbidities, CD4(+) T lymphocyte count, total cholesterol and fractions, and triglyceride levels. There was no significant difference in vitamin A or beta-carotene concentrations in patients under the different HAART regimens. However, approximately 4% of the patients had deficient/low concentrations of vitamin A (<0.70 mu mol/L), and 98% showed concentrations of beta-carotene <1.0 mu mol/L. In conclusion, HIV/AIDS patients in this region will not benefit from vitamin A supplementation, independently of the HAART regimen utilized, but beta-carotene may be of importance, considering its antioxidant effect.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo State Research Foundation-FAPESP, Brazil [2008/56395-5]
dc.identifier.citationJOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, v.59, n.6, p.496-502, 2013
dc.identifier.doi10.3177/jnsv.59.496
dc.identifier.eissn1881-7742
dc.identifier.issn0301-4800
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5130
dc.language.isoeng
dc.publisherCENTER ACADEMIC PUBL JAPAN
dc.relation.ispartofJournal of Nutritional Science and Vitaminology
dc.rightsrestrictedAccess
dc.rights.holderCopyright CENTER ACADEMIC PUBL JAPAN
dc.subjectHIV infection
dc.subjectHAART
dc.subjectvitamin A
dc.subjectbeta-carotene
dc.subjectmicronutrients
dc.subject.otherhiv-infected patients
dc.subject.othermicronutrient supplementation
dc.subject.otherdisease progression
dc.subject.otherdrug-users
dc.subject.otherserum
dc.subject.otherdeficiency
dc.subject.otherretinol
dc.subject.othertrial
dc.subject.otheratherosclerosis
dc.subject.otherassociation
dc.subject.wosNutrition & Dietetics
dc.titleVitamin A and Beta-Carotene Concentrations in Adults with HIV/AIDS on Highly Active Antiretroviral Therapy
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalKAIO, Daniella Junko:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil
hcfmusp.author.externalRONDO, Patricia Helen Carvalho:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil
hcfmusp.author.externalSOUZA, Jose Maria Pacheco:Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, BR-01246904 Sao Paulo, Brazil
hcfmusp.author.externalFIRMINO, Aline Vale:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil
hcfmusp.author.externalLUZIA, Liania Alves:Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcALUISIO AUGUSTO COTRIM SEGURADO
hcfmusp.description.beginpage496
hcfmusp.description.endpage502
hcfmusp.description.issue6
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.pubmed24477245
hcfmusp.origem.scopus2-s2.0-84893369359
hcfmusp.origem.wosWOS:000329383800003
hcfmusp.publisher.cityTOKYO
hcfmusp.publisher.countryJAPAN
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