Cancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinoma

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMATOS, Leandro Luongo
dc.contributor.authorMENDERICO JUNIOR, Gilberto Mendes
dc.contributor.authorTHEODORO, Therese Rachell
dc.contributor.authorPASINI, Fatima Solange
dc.contributor.authorISHIKAWA, Marina de Menezes
dc.contributor.authorRIBEIRO, Andromeda Aryane Bomtempo
dc.contributor.authorMELLO, Evandro Sobroza de
dc.contributor.authorPINHAL, Maria Aparecida da Silva
dc.contributor.authorMOYSES, Raquel Ajub
dc.contributor.authorKULCSAR, Marco Aurelio Vamondes
dc.contributor.authorDEDIVITIS, Rogerio Aparecido
dc.contributor.authorCERNEA, Claudio Roberto
dc.contributor.authorKOWALSKI, Luiz Paulo
dc.date.accessioned2021-02-18T13:46:33Z
dc.date.available2021-02-18T13:46:33Z
dc.date.issued2020
dc.description.abstractThe objective of the present study was to evaluate the role of microRNA-mediated remodeling of the extracellular matrix in the process of tumor invasion of oral squamous cell carcinoma and to evaluate its relationship with the prognosis of these patients. This was a retrospective study on material from the paraffin blocks of patients operated on for oral squamous cell carcinoma, in addition to a group of healthy oral mucosa samples of paired patients. miR-1-3p, miR-133-3p, and miR-21-5p were differentially expressed between the superficial and deep tumor groups. miR-21-5p was the one with the greatest accuracy in the differentiation between superficial and deep tumors. By immunohistochemistry, the group of deep tumors showed greater immunoreactivity to matrix metalloproteinases 2 and 9 and laminin a in tumor-associated fibroblasts, with consequent degradation of the basal membrane, measured by greater loss of continuity of type IV collagen. This process was also associated with lower and higher expression of miR-1-3p and miR-21-5p, respectively. There was also a trend toward better overall and disease-free survival rates in patients with higher miR-133a-3p. The present study showed the interaction between microRNAs and extracellular matrix remodeling in oral squamous cell carcinoma.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) - Governamental research agency of the state of Sao Paulo, BrazilFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2016/01740-6]
dc.identifier.citationORAL ONCOLOGY, v.110, article ID 104909, 9p, 2020
dc.identifier.doi10.1016/j.oraloncology.2020.104909
dc.identifier.eissn1879-0593
dc.identifier.issn1368-8375
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/39362
dc.language.isoeng
dc.publisherELSEVIEReng
dc.relation.ispartofOral Oncology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright ELSEVIEReng
dc.subjectCarcinoma, squamous celleng
dc.subjectMoutheng
dc.subjectmicroRNAseng
dc.subjectNeoplasm invasivenesseng
dc.subjectCarcinogenesiseng
dc.subject.othertumor thicknesseng
dc.subject.othermesenchymal transitioneng
dc.subject.other8th editioneng
dc.subject.othermetastasiseng
dc.subject.otherexpressioneng
dc.subject.otherrecurrenceeng
dc.subject.othergrowtheng
dc.subject.othercavityeng
dc.subject.othermir-1eng
dc.subject.otherheadeng
dc.subject.wosOncologyeng
dc.subject.wosDentistry, Oral Surgery & Medicineeng
dc.titleCancer-associated fibroblast regulation by microRNAs promotes invasion of oral squamous cell carcinomaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalTHEODORO, Therese Rachell:Fac Med ABC, Biochem Dept, Santo Andre, SP, Brazil
hcfmusp.author.externalISHIKAWA, Marina de Menezes:Fac Israelita Ciencias Saude Albert Einstein, Nursery Sch, Sao Paulo, Brazil
hcfmusp.author.externalPINHAL, Maria Aparecida da Silva:Fac Med ABC, Biochem Dept, Santo Andre, SP, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcLEANDRO LUONGO DE MATOS
hcfmusp.contributor.author-fmusphcGILBERTO MENDES MENDERICO JUNIOR
hcfmusp.contributor.author-fmusphcFATIMA SOLANGE PASINI
hcfmusp.contributor.author-fmusphcANDROMEDA ARYANE BOMTEMPO RIBEIRO
hcfmusp.contributor.author-fmusphcEVANDRO SOBROZA DE MELLO
hcfmusp.contributor.author-fmusphcRAQUEL AJUB MOYSES
hcfmusp.contributor.author-fmusphcMARCO AURELIO VAMONDES KULCSAR
hcfmusp.contributor.author-fmusphcROGERIO APARECIDO DEDIVITIS
hcfmusp.contributor.author-fmusphcCLAUDIO ROBERTO CERNEA
hcfmusp.contributor.author-fmusphcLUIZ PAULO KOWALSKI
hcfmusp.description.articlenumber104909
hcfmusp.description.volume110
hcfmusp.origemWOS
hcfmusp.origem.pubmed32702628
hcfmusp.origem.scopus2-s2.0-85088130795
hcfmusp.origem.wosWOS:000584539100035
hcfmusp.publisher.cityAMSTERDAMeng
hcfmusp.publisher.countryNETHERLANDSeng
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