Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFERNANDES, Juliane Cristina Ribeiro
dc.contributor.authorAOKI, Juliana Ide
dc.contributor.authorACUNA, Stephanie Maia
dc.contributor.authorZAMPIERI, Ricardo Andrade
dc.contributor.authorMARKUS, Regina P.
dc.contributor.authorFLOETER-WINTER, Lucile Maria
dc.contributor.authorMUXEL, Sandra Marcia
dc.date.accessioned2019-05-30T13:57:47Z
dc.date.available2019-05-30T13:57:47Z
dc.date.issued2019
dc.description.abstractLeishmaniases are neglected diseases that cause a large spectrum of clinical manifestations, from cutaneous to visceral lesions. The initial steps of the inflammatory response involve the phagocytosis of Leishmania and the parasite replication inside the macrophage phagolysosome. Melatonin, the darkness-signaling hormone, is involved in modulation of macrophage activation during infectious diseases, controlling the inflammatory response against parasites. In this work, we showed that exogenous melatonin treatment of BALB/c macrophages reduced Leishmania amazonensis infection and modulated host microRNA (miRNA) expression profile, as well as cytokine production such as IL-6, MCP-1/CCL2, and, RANTES/CCL9. The role of one of the regulated miRNA (miR-294-3p) in L. amazonensis BALB/c infection was confirmed with miRNA inhibition assays, which led to increased expression levels of Tnf and Mcp-1/Ccl2 and diminished infectivity. Additionally, melatonin treatment or miR-30e-5p and miR-302d-3p inhibition increased nitric oxide synthase 2 (Nos2) mRNA expression levels and nitric oxide (NO) production, altering the macrophage activation state and reducing infection. Altogether, these data demonstrated the impact of melatonin treatment on the miRNA profile of BALB/c macrophage infected with L. amazonensis defining the infection outcome.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [479399/2012-3, 307587/2014-2, 406351/2018-0]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/15263-4, 2014/50717-1, 2016/19815-2, 2016/03273-6, 2017/201906-9, 2017/23519-2]
dc.identifier.citationFRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v.9, article ID 60, 15p, 2019
dc.identifier.doi10.3389/fcimb.2019.00060
dc.identifier.issn2235-2988
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/32030
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SAeng
dc.relation.ispartofFrontiers in Cellular and Infection Microbiology
dc.rightsopenAccesseng
dc.rights.holderCopyright FRONTIERS MEDIA SAeng
dc.subjectpolyamine pathwayeng
dc.subjectnitric oxide synthaseeng
dc.subjectarginase 1eng
dc.subjectinterleukineng
dc.subjectmRNA-miRNA interactioneng
dc.subjectmelatonin and Leishmaniaeng
dc.subject.othernitric-oxide synthaseeng
dc.subject.othergene-expressioneng
dc.subject.othermice lackingeng
dc.subject.othermacrophage activationeng
dc.subject.othermurine macrophageseng
dc.subject.otherimmune-responseseng
dc.subject.otherstromal cellseng
dc.subject.othermicrornaseng
dc.subject.otherinductioneng
dc.subject.othersurvivaleng
dc.subject.wosImmunologyeng
dc.subject.wosMicrobiologyeng
dc.titleMelatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expressioneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalAOKI, Juliana Ide:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
hcfmusp.author.externalACUNA, Stephanie Maia:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
hcfmusp.author.externalZAMPIERI, Ricardo Andrade:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
hcfmusp.author.externalMARKUS, Regina P.:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
hcfmusp.author.externalFLOETER-WINTER, Lucile Maria:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
hcfmusp.author.externalMUXEL, Sandra Marcia:Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Sao Paulo, Brazil
hcfmusp.citation.scopus30
hcfmusp.contributor.author-fmusphcJULIANE CRISTINA RIBEIRO FERNANDES
hcfmusp.description.articlenumber60
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed30949455
hcfmusp.origem.scopus2-s2.0-85064318107
hcfmusp.origem.wosWOS:000461821300002
hcfmusp.publisher.cityLAUSANNEeng
hcfmusp.publisher.countrySWITZERLANDeng
hcfmusp.relation.referenceAlvar J, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0035671eng
hcfmusp.relation.referenceAshford RW, 2000, INT J PARASITOL, V30, P1269, DOI 10.1016/S0020-7519(00)00136-3eng
hcfmusp.relation.referenceBagga S, 2005, CELL, V122, P553, DOI 10.1016/j.cell.2005.07.031eng
hcfmusp.relation.referenceBaltimore D, 2008, NAT IMMUNOL, V9, P839, DOI 10.1038/ni.f.209eng
hcfmusp.relation.referenceBanerjee S, 2013, J IMMUNOL, V190, P6542, DOI 10.4049/jimmunol.1202496eng
hcfmusp.relation.referenceBen-Othman R, 2009, MOL IMMUNOL, V46, P3438, DOI 10.1016/j.molimm.2009.05.337eng
hcfmusp.relation.referenceBoucher JL, 1999, CELL MOL LIFE SCI, V55, P1015, DOI 10.1007/s000180050352eng
hcfmusp.relation.referenceCarrillo-Vico A, 2004, FASEB J, V18, P537, DOI 10.1096/fj.03-0694fjeeng
hcfmusp.relation.referenceCarrillo-Vico A, 2005, ENDOCRINE, V27, P189, DOI 10.1385/ENDO:27:2:189eng
hcfmusp.relation.referenceCarrillo-Vico A, 2013, INT J MOL SCI, V14, P8638, DOI 10.3390/ijms14048638eng
hcfmusp.relation.referenceCarvalho-Sousa Claudia Emanuele, 2011, Front Endocrinol (Lausanne), V2, P10, DOI 10.3389/fendo.2011.00010eng
hcfmusp.relation.referenceCORRALIZA IM, 1995, BIOCHEM BIOPH RES CO, V206, P667, DOI 10.1006/bbrc.1995.1094eng
hcfmusp.relation.referenceCruz-Machado SD, 2010, J PINEAL RES, V49, P183, DOI 10.1111/j.1600-079X.2010.00785.xeng
hcfmusp.relation.referenceDavid Y, 2010, J BIOL CHEM, V285, P8595, DOI 10.1074/jbc.M109.089003eng
hcfmusp.relation.referenceDeng WG, 2006, BLOOD, V108, P518, DOI 10.1182/blood-2005-09-3691eng
hcfmusp.relation.referenceDillon LAL, 2015, BMC GENOMICS, V16, DOI 10.1186/s12864-015-2237-2eng
hcfmusp.relation.referenceEl-Sokkary GH, 2002, FREE RADICAL BIO MED, V32, P319, DOI 10.1016/S0891-5849(01)00753-5eng
hcfmusp.relation.referenceFarlik M, 2010, IMMUNITY, V33, P25, DOI 10.1016/j.immuni.2010.07.001eng
hcfmusp.relation.referenceFernandes MC, 2016, MBIO, V7, DOI 10.1128/mBio.00027-16eng
hcfmusp.relation.referenceFletcher AJ, 2015, P NATL ACAD SCI USA, V112, P10014, DOI 10.1073/pnas.1507534112eng
hcfmusp.relation.referenceFrank B, 2015, PARASITE VECTOR, V8, DOI 10.1186/s13071-015-0974-3eng
hcfmusp.relation.referenceGeraci NS, 2015, PARASITE IMMUNOL, V37, P43, DOI 10.1111/pim.12156eng
hcfmusp.relation.referenceGHALIB HW, 1995, J IMMUNOL, V154, P4623eng
hcfmusp.relation.referenceGhosh J, 2013, CELL HOST MICROBE, V13, P277, DOI 10.1016/j.chom.2013.02.005eng
hcfmusp.relation.referenceGilad E, 1998, FASEB J, V12, P685eng
hcfmusp.relation.referenceGraff JW, 2012, J BIOL CHEM, V287, P21816, DOI 10.1074/jbc.M111.327031eng
hcfmusp.relation.referenceGregory DJ, 2005, PARASITOLOGY, V130, pS27, DOI 10.1017/S0031182005008139eng
hcfmusp.relation.referenceHershkovitz-Rokah O, 2015, CANCER LETT, V356, P597, DOI 10.1016/j.canlet.2014.10.006eng
hcfmusp.relation.referenceHornung D, 1997, J CLIN ENDOCR METAB, V82, P1621, DOI 10.1210/jc.82.5.1621eng
hcfmusp.relation.referenceHornung D, 2001, MOL HUM REPROD, V7, P163, DOI 10.1093/molehr/7.2.163eng
hcfmusp.relation.referenceHotta CT, 2000, NAT CELL BIOL, V2, P466eng
hcfmusp.relation.referenceHoubaviy HB, 2003, DEV CELL, V5, P351, DOI 10.1016/S1534-5807(03)00227-2eng
hcfmusp.relation.referenceHrabak A, 1996, FEBS LETT, V390, P203, DOI 10.1016/0014-5793(96)00659-Xeng
hcfmusp.relation.referenceIkeda F, 2008, EMBO REP, V9, P536, DOI 10.1038/embor.2008.93eng
hcfmusp.relation.referenceJiang LL, 2012, J CLIN INVEST, V122, P33, DOI 10.1172/JCI58849eng
hcfmusp.relation.referenceKinsey SG, 2003, PHYSIOL BEHAV, V78, P205, DOI 10.1016/S0031-9384(02)00967-8eng
hcfmusp.relation.referenceElmahallawy EK, 2014, CHEM-BIOL INTERACT, V220, P84, DOI 10.1016/j.cbi.2014.06.016eng
hcfmusp.relation.referenceLaranjeira-Silva MF, 2015, J PINEAL RES, V59, P478, DOI 10.1111/jpi.12279eng
hcfmusp.relation.referenceLebovic DI, 2001, J CLIN ENDOCR METAB, V86, P4759, DOI 10.1210/jc.86.10.4759eng
hcfmusp.relation.referenceLemaire J, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002478eng
hcfmusp.relation.referenceLim LP, 2005, NATURE, V433, P769, DOI 10.1038/nature03315eng
hcfmusp.relation.referenceLima DS, 2013, NAT MED, V19, P909, DOI 10.1038/nm.3221eng
hcfmusp.relation.referenceLotufo CMC, 2006, EUR J PHARMACOL, V534, P258, DOI 10.1016/j.ejphar.2006.01.050eng
hcfmusp.relation.referenceLotufo CMC, 2001, EUR J PHARMACOL, V430, P351, DOI 10.1016/S0014-2999(01)01369-3eng
hcfmusp.relation.referenceLuchetti F, 2010, FASEB J, V24, P3603, DOI 10.1096/fj.10-154450eng
hcfmusp.relation.referenceMaestroni GJM, 1996, J PINEAL RES, V20, P84, DOI 10.1111/j.1600-079X.1996.tb00244.xeng
hcfmusp.relation.referenceMantovani A, 2004, TRENDS IMMUNOL, V25, P677, DOI 10.1016/j.it.2004.09.015eng
hcfmusp.relation.referenceMarcola M, 2013, J PINEAL RES, V54, P162, DOI 10.1111/j.1600-079X.2012.01025.xeng
hcfmusp.relation.referenceMarkus RP, 2007, NEUROIMMUNOMODULAT, V14, P126, DOI 10.1159/000110635eng
hcfmusp.relation.referenceMarkus RP, 2018, BRIT J PHARMACOL, V175, P3239, DOI 10.1111/bph.14083eng
hcfmusp.relation.referenceMARSDEN PD, 1986, T ROY SOC TROP MED H, V80, P859, DOI 10.1016/0035-9203(86)90243-9eng
hcfmusp.relation.referenceMartinez FO, 2009, ANNU REV IMMUNOL, V27, P451, DOI 10.1146/annurev.immunol.021908.132532eng
hcfmusp.relation.referenceMosser DM, 2008, NAT REV IMMUNOL, V8, P958, DOI 10.1038/nri2448eng
hcfmusp.relation.referenceMukherjee B, 2015, J IMMUNOL, V195, P2731, DOI 10.4049/jimmunol.1402585eng
hcfmusp.relation.referenceMuller K, 2001, MED MICROBIOL IMMUN, V190, P73eng
hcfmusp.relation.referenceMunder M, 1998, J IMMUNOL, V160, P5347eng
hcfmusp.relation.referenceMuxel S. M., 2017, PROTOCOL EXCHANGE, P1, DOI [10.1038/protex.2017.034, DOI 10.1038/PROTEX.2017.034]eng
hcfmusp.relation.referenceMuxel SM, 2018, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.02682eng
hcfmusp.relation.referenceMuxel SM, 2018, FRONT IMMUNOL, V9, DOI 10.3389/fimmu.2018.02792eng
hcfmusp.relation.referenceMuxel SM, 2017, SCI REP-UK, V7, DOI 10.1038/srep44141eng
hcfmusp.relation.referenceMuxel SM, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0052010eng
hcfmusp.relation.referenceNair SM, 2011, J PINEAL RES, V51, P313, DOI 10.1111/j.1600-079X.2011.00891.xeng
hcfmusp.relation.referenceNathan C, 2000, P NATL ACAD SCI USA, V97, P8841, DOI 10.1073/pnas.97.16.8841eng
hcfmusp.relation.referenceO'Neill LA, 2011, NAT REV IMMUNOL, V11, P163, DOI 10.1038/nri2957eng
hcfmusp.relation.referenceOHMORI Y, 1994, J IMMUNOL, V153, P2204eng
hcfmusp.relation.referencePark HJ, 2007, J PINEAL RES, V43, P121, DOI 10.1111/j.1600-079X.2007.00452.xeng
hcfmusp.relation.referencePires-Lapa MA, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082182eng
hcfmusp.relation.referencePontes GN, 2006, J PINEAL RES, V41, P136, DOI 10.1111/j.1600-079X.2006.00345.xeng
hcfmusp.relation.referencePrendergast BJ, 2003, J BIOL RHYTHM, V18, P51, DOI 10.1177/0748730402239676eng
hcfmusp.relation.referenceRecchiuti A, 2011, FASEB J, V25, P544, DOI 10.1096/fj.10-169599eng
hcfmusp.relation.referenceReiter RJ, 2000, ANN NY ACAD SCI, V917, P376eng
hcfmusp.relation.referenceReiter RJ, 2013, MINI-REV MED CHEM, V13, P373eng
hcfmusp.relation.referenceRen DL, 2015, J PINEAL RES, V58, P452, DOI 10.1111/jpi.12230eng
hcfmusp.relation.referenceRoh YS, 2014, J GASTROENTEROL, V49, P185, DOI 10.1007/s00535-013-0931-xeng
hcfmusp.relation.referenceRojas IG, 2002, BRAIN BEHAV IMMUN, V16, P74, DOI 10.1006/brbi.2000.0619eng
hcfmusp.relation.referenceSantello FH, 2008, J PINEAL RES, V45, P291, DOI 10.1111/j.1600-079X.2008.00589.xeng
hcfmusp.relation.referenceSantello FH, 2008, J PINEAL RES, V45, P79, DOI 10.1111/j.1600-079X.2008.00558.xeng
hcfmusp.relation.referenceSantello FH, 2007, J PINEAL RES, V42, P359, DOI 10.1111/j.1600-079X.2007.00427.xeng
hcfmusp.relation.referenceSCHALL TJ, 1993, J EXP MED, V177, P1821, DOI 10.1084/jem.177.6.1821eng
hcfmusp.relation.referenceScott P, 2016, NAT REV IMMUNOL, V16, P581, DOI 10.1038/nri.2016.72eng
hcfmusp.relation.referenceSmith S, 2017, J AUTOIMMUN, V79, P105, DOI 10.1016/j.jaut.2017.03.003eng
hcfmusp.relation.referenceSrivastava A, 2012, MOL CELL BIOCHEM, V359, P359, DOI 10.1007/s11010-011-1029-5eng
hcfmusp.relation.referenceTamura EK, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013958eng
hcfmusp.relation.referenceVerreck FAW, 2004, P NATL ACAD SCI USA, V101, P4560, DOI 10.1073/pnas.0400983101eng
hcfmusp.relation.referenceVieira LQ, 1996, J IMMUNOL, V157, P827eng
hcfmusp.relation.referenceWanasen N, 2008, IMMUNOL RES, V41, P15, DOI 10.1007/s12026-007-8012-yeng
hcfmusp.relation.referenceWang N, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00614eng
hcfmusp.relation.referenceWang Y, 2008, CLIN GENET, V74, P307, DOI 10.1111/j.1399-0004.2008.01075.xeng
hcfmusp.relation.referenceWEI XQ, 1995, NATURE, V375, P408, DOI 10.1038/375408a0eng
hcfmusp.relation.referenceWilhelm P, 2001, J IMMUNOL, V166, P4012, DOI 10.4049/jimmunol.166.6.4012eng
hcfmusp.relation.referenceWorld Health Organization, 2017, LEISHMANIASISeng
hcfmusp.relation.referenceWu YQ, 2017, EXP THER MED, V14, P3299, DOI 10.3892/etm.2017.4872eng
hcfmusp.relation.referenceXia MZ, 2012, J PINEAL RES, V53, P325, DOI 10.1111/j.1600-079X.2012.01002.xeng
hcfmusp.relation.referenceXu XF, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-34011-8eng
hcfmusp.relation.referenceYang J, 2013, ACTA BIOCH BIOPH SIN, V45, P938, DOI 10.1093/abbs/gmt100eng
hcfmusp.relation.referenceYang ZY, 2007, J IMMUNOL, V178, P1077, DOI 10.4049/jimmunol.178.2.1077eng
hcfmusp.relation.referenceZhang HM, 2014, J PINEAL RES, V57, P131, DOI 10.1111/jpi.12162eng
hcfmusp.relation.referenceZhang X, 2008, J PATHOL, V214, P161, DOI 10.1002/path.2284eng
hcfmusp.relation.referenceZheng GXY, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1002054eng
hcfmusp.relation.referenceZhou LL, 2010, MEDIAT INFLAMM, DOI 10.1155/2010/951210eng
hcfmusp.relation.referenceZhu X, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0003088eng
hcfmusp.relation.referenceZhuang L, 2017, J CELL MOL MED, V21, P2852, DOI 10.1111/jcmm.13198eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublicationfefb0291-d290-4293-a38d-43ba0a6245d2
relation.isAuthorOfPublication.latestForDiscoveryfefb0291-d290-4293-a38d-43ba0a6245d2
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_FERNANDES_Melatonin_and_Leishmania_amazonensis_Infection_Altered_miR294_miR30e_2019.PDF
Tamanho:
4.88 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - IMT