Efficacy of vitamin D supplementation among persons living with HIV/AIDS in Sao Paulo city, Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorALMEIDA-AFONSO, Rosa
dc.contributor.authorFINAMOR, Danilo
dc.contributor.authorFONSECA, Luiz Augusto M.
dc.contributor.authorVEIGA, Ana P. Rocha
dc.contributor.authorMONTEIRO, Mariana A.
dc.contributor.authorMAGRI, Marcello
dc.contributor.authorDUARTE, Alberto J. S.
dc.contributor.authorCASSEB, Jorge
dc.contributor.groupauthorHosp Clinicas
dc.contributor.groupauthorServ Dermatol
dc.contributor.groupauthorFac Med LIM56
dc.contributor.groupauthorInst Med Tropical Sao Paulo
dc.contributor.groupauthorUniv Sao Paulo
dc.date.accessioned2021-10-20T14:02:17Z
dc.date.available2021-10-20T14:02:17Z
dc.date.issued2021
dc.description.abstractHypovitaminosis D is now considered a pandemic, especially among more vulnerable populations and in HIV-infected subjects, with 80% presenting levels below 30 ng/mL. As there is no consensus on the more adequate dosage needed to correct such deficiency, the objective of this study was to evaluate 25 (OH) vitamin D supplementation in HIV-1 patients deficient of vitamin D. A total of 73 HIV-1-infected patients were included, drawn from a cohort of 435 patients; 37 patients were randomized to the active group, supplemented once a week with 50,000 UI vitamin D by mouth (group 1) and 36 to the placebo group (group 2). The study period ranged from June 2016 to September 2017. Variables involved in vitamin D metabolism and risk factors associated with hypovitaminosis were evaluated. The mean age was 45 years and 31.5 % were women. Vitamin D supplementation was effective in normalizing serum levels after six months in group 1 (mean 35 ng/mL compared to 21 ng/mL for the placebo group; p = 0.04). No patient reached blood levels considered toxic (>100 UI). Efavirenz use can negatively influence vitamin D levels and supplementation is necessary as a likely adjunct to improving CD4+ T cells, resulting in greater effectiveness of the treatment. A weekly oral dose of 50,000 IU of vitamin D was sufficient to normalize the vitamin deficiency, safely and with good adherence among persons living with HIV/AIDS in Brazil. (C) 2021 Sociedade Brasileira de Infectologia.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/07239-2]
dc.description.sponsorshipCNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [301275/2019-0]
dc.description.sponsorshipFFM/FMUSP
dc.identifier.citationBRAZILIAN JOURNAL OF INFECTIOUS DISEASES, v.25, n.3, article ID 101598, 5p, 2021
dc.identifier.doi10.1016/j.bjid.2021.101598
dc.identifier.eissn1678-4391
dc.identifier.issn1413-8670
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/42374
dc.language.isoeng
dc.publisherELSEVIER BRAZILeng
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER BRAZILeng
dc.subjectVitamin D deficiencyeng
dc.subjectHIVeng
dc.subjectsupplementationeng
dc.subjectBrazileng
dc.subject.otherd deficiencyeng
dc.subject.otherprevalenceeng
dc.subject.wosInfectious Diseaseseng
dc.titleEfficacy of vitamin D supplementation among persons living with HIV/AIDS in Sao Paulo city, Brazileng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalFINAMOR, Danilo:Ctr Referencia IST AIDS, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcROSA ALMEIDA AFONSO
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO MARCONDES FONSECA
hcfmusp.contributor.author-fmusphcANA PAULA ROCHA VEIGA
hcfmusp.contributor.author-fmusphcMARIANA AMELIA MONTEIRO
hcfmusp.contributor.author-fmusphcMARCELLO MIHAILENKO CHAVES MAGRI
hcfmusp.contributor.author-fmusphcALBERTO JOSE DA SILVA DUARTE
hcfmusp.contributor.author-fmusphcJORGE SIMAO DO ROSARIO CASSEB
hcfmusp.description.articlenumber101598
hcfmusp.description.issue3
hcfmusp.description.volume25
hcfmusp.origemWOS
hcfmusp.origem.pubmed34280356
hcfmusp.origem.scieloSCIELO:S1413-86702021000300204
hcfmusp.origem.scopus2-s2.0-85111913001
hcfmusp.origem.wosWOS:000691288800012
hcfmusp.publisher.cityRIO DE JANEIROeng
hcfmusp.publisher.countryBRAZILeng
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hcfmusp.scopus.lastupdate2024-05-10
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