HLA-C downregulation by HIV-1 adapts to host HLA genotype

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBECHTEL, Nathaniel D.
dc.contributor.authorUMVILIGIHOZO, Gisele
dc.contributor.authorPICKERING, Suzanne
dc.contributor.authorMOTA, Talia M.
dc.contributor.authorLIANG, Hua
dc.contributor.authorPRETE, Gregory Q. Del
dc.contributor.authorCHATTERJEE, Pramita
dc.contributor.authorLEE, Guinevere Q.
dc.contributor.authorTHOMAS, Rasmi
dc.contributor.authorBROCKMAN, Mark A.
dc.contributor.authorNEIL, Stuart
dc.contributor.authorCARRINGTON, Mary
dc.contributor.authorBWANA, Bosco
dc.contributor.authorBANGSBERG, David R.
dc.contributor.authorMARTIN, Jeffrey N.
dc.contributor.authorKALLAS, Esper G.
dc.contributor.authorDONINI, Camila S.
dc.contributor.authorCERQUEIRA, Natalia B.
dc.contributor.authorO'DOHERTY, Una T.
dc.contributor.authorHAHN, Beatrice H.
dc.contributor.authorJONES, R. Brad
dc.contributor.authorBRUMME, Zabrina L.
dc.contributor.authorNIXON, Douglas F.
dc.contributor.authorAPPS, Richard
dc.date.accessioned2019-02-21T17:21:10Z
dc.date.available2019-02-21T17:21:10Z
dc.date.issued2018
dc.description.abstractHIV-1 can downregulate HLA-C on infected cells, using the viral protein Vpu, and the magnitude of this downregulation varies widely between primary HIV-1 variants. The selection pressures that result in viral downregulation of HLA-C in some individuals, but preservation of surface HLA-C in others are not clear. To better understand viral immune evasion targeting HLA-C, we have characterized HLA-C downregulation by a range of primary HIV-1 viruses. 128 replication competent viral isolates from 19 individuals with effective anti-retroviral therapy, show that a substantial minority of individuals harbor latent reservoir virus which strongly downregulates HLA-C. Untreated infections display no change in HLA-C downregulation during the first 6 months of infection, but variation between viral quasispecies can be detected in chronic infection. Vpu molecules cloned from plasma of 195 treatment naive individuals in chronic infection demonstrate that downregulation of HLA-C adapts to host HLA genotype. HLA-C alleles differ in the pressure they exert for downregulation, and individuals with higher levels of HLA-C expression favor greater viral downregulation of HLA-C. Studies of primary and mutant molecules identify 5 residues in the transmembrane region of Vpu, and 4 residues in the transmembrane domain of HLA-C, which determine interactions between Vpu and HLA. The observed adaptation of Vpu-mediated downregulation to host genotype indicates that HLA-C alleles differ in likelihood of mediating a CTL response that is subverted by viral downregulation, and that preservation of HLA-C expression is favored in the absence of these responses. Finding that latent reservoir viruses can downregulate HLA-C could have implications for HIV-1 cure therapy approaches in some individuals.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases of the National Institutes of Health [UM1AI126617]
dc.description.sponsorshipNational Institute on Drug Abuse
dc.description.sponsorshipNational Institute of Mental Health
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NIAID [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NCI [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NICHD [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NHLBI [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NIDA [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NIMH [AI117970]
dc.description.sponsorshipFrederick National Laboratory for Cancer Research
dc.description.sponsorshipNational Cancer Institute, National Institutes of Health [HHSN261200800001E]
dc.description.sponsorshipIntramural Research Program of the NIH, Frederick National Lab, Center for Cancer Research
dc.description.sponsorshipWellcome Trust [WT098049AIA]
dc.description.sponsorshipMRC UK [G0801937]
dc.description.sponsorshipCanadian Institutes of Health Research [PJT-148621]
dc.description.sponsorshipMichael Smith Foundation for Health Research
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NIA [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - FIC [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NIGMS [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - NIDDK [AI117970]
dc.description.sponsorshipDistrict of Columbia Center for AIDS Research, an NIH - OAR [AI117970]
dc.description.sponsorshipCanada Research Chair in Viral Pathogenesis and Immunity
dc.identifier.citationPLOS PATHOGENS, v.14, n.9, article ID e1007257, 25p, 2018
dc.identifier.doi10.1371/journal.ppat.1007257
dc.identifier.eissn1553-7374
dc.identifier.issn1553-7366
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30795
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCEeng
dc.relation.ispartofPlos Pathogens
dc.rightsopenAccesseng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.subject.othercytotoxic t-lymphocyteseng
dc.subject.othernatural-killer-cellseng
dc.subject.otherclass-i moleculeseng
dc.subject.othercomplex class-ieng
dc.subject.otherimmunodeficiency-viruseng
dc.subject.othernef proteineng
dc.subject.othernk cellseng
dc.subject.othersurface expressioneng
dc.subject.otherinfected cellseng
dc.subject.otherimmune controleng
dc.subject.wosMicrobiologyeng
dc.subject.wosParasitologyeng
dc.subject.wosVirologyeng
dc.titleHLA-C downregulation by HIV-1 adapts to host HLA genotypeeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryUganda
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisous
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisogb
hcfmusp.affiliation.countryisoug
hcfmusp.author.externalBECHTEL, Nathaniel D.:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA
hcfmusp.author.externalUMVILIGIHOZO, Gisele:Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada
hcfmusp.author.externalPICKERING, Suzanne:Kings Coll London, Sch Med, Guys Hosp, Dept Infect Dis, London, England
hcfmusp.author.externalMOTA, Talia M.:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA; Weill Cornell Med Coll, Div Infect Dis, Dept Med, New York, NY USA
hcfmusp.author.externalLIANG, Hua:George Washington Univ, Dept Stat & Biostat, Washington, DC USA
hcfmusp.author.externalPRETE, Gregory Q. Del:Frederick Natl Lab Canc Res, AIDS & Canc Virus Program, Frederick, MD USA
hcfmusp.author.externalCHATTERJEE, Pramita:Frederick Natl Lab Canc Res, Canc & Inflammat Program, HLA Immunogenet Sect, Basic Sci Program, Frederick, MD USA
hcfmusp.author.externalLEE, Guinevere Q.:Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA USA
hcfmusp.author.externalTHOMAS, Rasmi:Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA; Henry M Jackson Fdn, Bethesda, MD USA
hcfmusp.author.externalBROCKMAN, Mark A.:Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada; British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada
hcfmusp.author.externalNEIL, Stuart:Kings Coll London, Sch Med, Guys Hosp, Dept Infect Dis, London, England
hcfmusp.author.externalCARRINGTON, Mary:Frederick Natl Lab Canc Res, Canc & Inflammat Program, HLA Immunogenet Sect, Basic Sci Program, Frederick, MD USA; Ragon Inst Massachusetts Gen Hosp Massachusetts I, Cambridge, MA USA
hcfmusp.author.externalBWANA, Bosco:Mbarara Univ Sci & Technol, Mbarara, Uganda
hcfmusp.author.externalBANGSBERG, David R.:Mbarara Univ Sci & Technol, Mbarara, Uganda; Portland State Univ, Sch Publ Hlth, Oregon Hlth & Sci Univ, Portland, OR 97207 USA
hcfmusp.author.externalMARTIN, Jeffrey N.:Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
hcfmusp.author.externalO'DOHERTY, Una T.:Univ Penn, Dept Med, Philadelphia, PA 19104 USA; Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA
hcfmusp.author.externalHAHN, Beatrice H.:Univ Penn, Dept Med, Philadelphia, PA 19104 USA; Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA
hcfmusp.author.externalJONES, R. Brad:Weill Cornell Med Coll, Div Infect Dis, Dept Med, New York, NY USA
hcfmusp.author.externalBRUMME, Zabrina L.:Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada; British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada
hcfmusp.author.externalNIXON, Douglas F.:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA; Weill Cornell Med Coll, Div Infect Dis, Dept Med, New York, NY USA
hcfmusp.author.externalAPPS, Richard:George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC 20037 USA; NIH, Trans NIH Ctr Human Immunol Autoimmun & Inflammat, Bldg 10, Bethesda, MD 20892 USA
hcfmusp.citation.scopus21
hcfmusp.contributor.author-fmusphcESPER GEORGES KALLAS
hcfmusp.contributor.author-fmusphcCAMILA SUNAITIS DONINI
hcfmusp.contributor.author-fmusphcNATALIA BARROS CERQUEIRA
hcfmusp.description.articlenumbere1007257
hcfmusp.description.issue9
hcfmusp.description.volume14
hcfmusp.origemWOS
hcfmusp.origem.pubmed30180214
hcfmusp.origem.scopus2-s2.0-85054588450
hcfmusp.origem.wosWOS:000448975900017
hcfmusp.publisher.citySAN FRANCISCOeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceApps R, 2016, CELL HOST MICROBE, V19, P686, DOI 10.1016/j.chom.2016.04.005eng
hcfmusp.relation.referenceApps R, 2015, J IMMUNOL, V194, P3594, DOI 10.4049/jimmunol.1403234eng
hcfmusp.relation.referenceApps R, 2013, SCIENCE, V340, P87, DOI 10.1126/science.1232685eng
hcfmusp.relation.referenceBaba M, 2000, AIDS RES HUM RETROV, V16, P935, DOI 10.1089/08892220050058344eng
hcfmusp.relation.referenceBartha I, 2013, ELIFE, V2, DOI 10.7554/eLife.01123eng
hcfmusp.relation.referenceBlais ME, 2012, J IMMUNOL, V188, P4663, DOI 10.4049/jimmunol.1103472eng
hcfmusp.relation.referenceBongiovanni M, 2006, J ANTIMICROB CHEMOTH, V58, P502, DOI 10.1093/jac/dkl268eng
hcfmusp.relation.referenceBORROW P, 1994, J VIROL, V68, P6103eng
hcfmusp.relation.referenceBraud VM, 1998, CURR BIOL, V8, P1, DOI 10.1016/S0960-9822(98)70014-4eng
hcfmusp.relation.referenceBrockman MA, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00506eng
hcfmusp.relation.referenceCarlson JM, 2016, NAT MED, V22, P606, DOI 10.1038/nm.4100eng
hcfmusp.relation.referenceCarlson JM, 2012, J VIROL, V86, P5230, DOI 10.1128/JVI.06728-11eng
hcfmusp.relation.referenceCarrington M, 2003, ANNU REV MED, V54, P535, DOI 10.1146/annurev.med.54.101601.152346eng
hcfmusp.relation.referenceCohen GB, 1999, IMMUNITY, V10, P661, DOI 10.1016/S1074-7613(00)80065-5eng
hcfmusp.relation.referenceCollins KL, 1998, NATURE, V391, P397, DOI 10.1038/34929eng
hcfmusp.relation.referenceDavis ZB, 2016, PLOS PATHOG, V12, DOI 10.1371/journal.ppat.1005421eng
hcfmusp.relation.referenceDEACON NJ, 1995, SCIENCE, V270, P988, DOI 10.1126/science.270.5238.988eng
hcfmusp.relation.referenceEnde Z., 2018, J VIROLeng
hcfmusp.relation.referenceFadda L, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002805eng
hcfmusp.relation.referenceFellay J, 2007, SCIENCE, V317, P944, DOI 10.1126/science.1143767eng
hcfmusp.relation.referenceFenton-May AE, 2013, RETROVIROLOGY, V10, DOI 10.1186/1742-4690-10-146eng
hcfmusp.relation.referenceFogli M, 2008, PLOS PATHOG, V4, DOI 10.1371/journal.ppat.1000101eng
hcfmusp.relation.referenceFoster TL, 2016, CELL HOST MICROBE, V20, P429, DOI 10.1016/j.chom.2016.08.006eng
hcfmusp.relation.referenceGoonetilleke N, 2009, J EXP MED, V206, P1253, DOI 10.1084/jem.20090365eng
hcfmusp.relation.referenceHerschhorn A, 2010, J IMMUNOL, V185, P7623, DOI 10.4049/jimmunol.1001561eng
hcfmusp.relation.referenceHiby SE, 2004, J EXP MED, V200, P957, DOI 10.1084/jem.20041214eng
hcfmusp.relation.referenceHirayasu K, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002565eng
hcfmusp.relation.referenceHonda K, 2011, EUR J IMMUNOL, V41, P97, DOI 10.1002/eji.201040841eng
hcfmusp.relation.referenceHoneyborne I, 2010, J VIROL, V84, P11279, DOI 10.1128/JVI.01144-10eng
hcfmusp.relation.referenceHosmane NN, 2017, J EXP MED, V214, P959, DOI 10.1084/jem.20170193eng
hcfmusp.relation.referenceHunt PW, 2011, AIDS, V25, P2123, DOI 10.1097/QAD.0b013e32834c4ac1eng
hcfmusp.relation.referenceIyer SS, 2017, P NATL ACAD SCI USA, V114, pE590, DOI 10.1073/pnas.1620144114eng
hcfmusp.relation.referenceJones RB, 2016, J CLIN INVEST, V126, P455, DOI 10.1172/JCI80566eng
hcfmusp.relation.referenceKARRE K, 1986, NATURE, V319, P675, DOI 10.1038/319675a0eng
hcfmusp.relation.referenceKhakoo SI, 2004, SCIENCE, V305, P872, DOI 10.1126/science.1097670eng
hcfmusp.relation.referenceKiepiela P, 2004, NATURE, V432, P769, DOI 10.1038/nature03113eng
hcfmusp.relation.referenceKIRCHHOFF F, 1995, NEW ENGL J MED, V332, P228, DOI 10.1056/NEJM199501263320405eng
hcfmusp.relation.referenceKorner C, 2017, CELL HOST MICROBE, V22, P111, DOI 10.1016/j.chom.2017.06.008eng
hcfmusp.relation.referenceKOUP RA, 1994, J VIROL, V68, P4650eng
hcfmusp.relation.referenceKueck T, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002609eng
hcfmusp.relation.referenceLaird GM, 2013, PLOS PATHOG, V9, DOI 10.1371/journal.ppat.1003398eng
hcfmusp.relation.referenceLin ZS, 2016, CELL REP, V17, P2210, DOI 10.1016/j.celrep.2016.10.075eng
hcfmusp.relation.referenceLynch RM, 2012, J VIROL, V86, P7588, DOI 10.1128/JVI.00734-12eng
hcfmusp.relation.referenceMakadzange AT, 2010, EUR J IMMUNOL, V40, P1036, DOI 10.1002/eji.200939634eng
hcfmusp.relation.referenceMann JK, 2013, RETROVIROLOGY, V10, DOI 10.1186/1742-4690-10-100eng
hcfmusp.relation.referenceMartini M, 2018, J DAIRY RES, V85, P445, DOI [10.1017/S0022029918000687, 10.1080/02770903.2018.1471705]eng
hcfmusp.relation.referenceNattermann J, 2005, ANTIVIR THER, V10, P95eng
hcfmusp.relation.referenceNdhlovu ZM, 2015, IMMUNITY, V43, P591, DOI 10.1016/j.immuni.2015.08.012eng
hcfmusp.relation.referenceNeil SJD, 2008, NATURE, V451, P425, DOI 10.1038/nature06553eng
hcfmusp.relation.referenceNou E, 2009, J VIROL, V83, P6941, DOI 10.1128/JVI.00306-09eng
hcfmusp.relation.referenceParham P, 2005, NAT REV IMMUNOL, V5, P201, DOI 10.1038/nri1570eng
hcfmusp.relation.referenceParolini F., 2017, J VIROL JVIeng
hcfmusp.relation.referenceParrish NF, 2012, PLOS PATHOG, V8, DOI 10.1371/journal.ppat.1002686eng
hcfmusp.relation.referencePatterson S, 2015, INT J EPIDEMIOL, V44, P58, DOI 10.1093/ije/dyu046eng
hcfmusp.relation.referencePereyra FP, 2010, SCIENCE, V330, P1551, DOI 10.1126/science.1195271eng
hcfmusp.relation.referencePickering S, 2014, PLOS PATHOG, V10, DOI 10.1371/journal.ppat.1003895eng
hcfmusp.relation.referenceR Development Core Team, 2017, R LANG ENV STAT COMPeng
hcfmusp.relation.referenceRahimi A, 2017, J VIROL METHODS, V240, P32, DOI 10.1016/j.jviromet.2016.11.004eng
hcfmusp.relation.referenceRobinson J, 2017, PLOS GENET, V13, DOI 10.1371/journal.pgen.1006862eng
hcfmusp.relation.referenceRomani B, 2017, SCI REP-UK, V7, DOI 10.1038/srep44894eng
hcfmusp.relation.referenceSauter D, 2015, CELL REP, V10, P586, DOI 10.1016/j.celrep.2014.12.047eng
hcfmusp.relation.referenceSchwartz O, 1996, NAT MED, V2, P338, DOI 10.1038/nm0396-338eng
hcfmusp.relation.referenceShah AH, 2010, CELL HOST MICROBE, V8, P397, DOI 10.1016/j.chom.2010.10.008eng
hcfmusp.relation.referenceSpecht A, 2010, J VIROL, V84, P7300, DOI 10.1128/JVI.00619-10eng
hcfmusp.relation.referenceStoll A, 2015, J IMMUNOL METHODS, V418, P9, DOI 10.1016/j.jim.2015.01.005eng
hcfmusp.relation.referenceSwigut T, 2004, J VIROL, V78, P13335, DOI 10.1128/JVI.78.23.13335-13344.2004eng
hcfmusp.relation.referenceThammavongsa V, 2009, IMMUNOGENETICS, V61, P703, DOI 10.1007/s00251-009-0399-2eng
hcfmusp.relation.referenceThomas R, 2009, NAT GENET, V41, P1290, DOI 10.1038/ng.486eng
hcfmusp.relation.referenceTremblay-McLean A, 2017, VIRUSES-BASEL, V9, DOI 10.3390/v9100295eng
hcfmusp.relation.referenceWILLEY RL, 1992, J VIROL, V66, P7193eng
hcfmusp.relation.referenceYang OO, 1996, J VIROL, V70, P5799eng
hcfmusp.relation.referenceZhang H, 2015, BBA-BIOMEMBRANES, V1848, P3007, DOI 10.1016/j.bbamem.2015.09.008eng
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