Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

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art_FURLAN_Hypopigmented_Mycosis_Fungoides_versus_Mycosis_Fungoides_with_Concomitant_2014.PDF (334.59 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2014
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
KARGER
Autores
Citação
DERMATOLOGY, v.229, n.3, p.271-274, 2014
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Hypopigmented mycosis fungoides (HMF) is a rare subtype of mycosis fungoides (ME). We compared patients with exclusive hypopigmented lesions with a group of MF patients with concomitant different lesions. Methods: 20 patients with HMF only and 14 patients with hypopigmented lesions concomitant with other types of lesions (mixed MF, MMF) were selected. Clinical-epidemiological analysis as well as histological and immunohistochemical studies were performed. Results: HMF and MMF preserve some similarities, like predilection for dark-skinned persons and slow progression, but they also present differences: the exclusive variant is associated with early onset and a clear CD8+ immunophenotype, whereas MMF patients tend to present a predominance of CD4+ cell infiltrates. Histological analysis revealed similar findings; relapsing courses were common. Conclusion: Whether patients are suffering from exclusive HMF or MMF, the presence of hypopigmented lesions can be considered a marker of good prognosis in MF, since both groups presented similar data, such as staging and disease duration. (C) 2014 S. Karger AG, Basel
Palavras-chave
Cutaneous T cell lymphoma, Hypopigmentation, Mycosis fungoides, Th1/Th2 cells
URI
https://observatorio.fm.usp.br/handle/OPI/8963
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/53
Artigos e Materiais de Revistas Científicas - ODS/03