Betapapillomavirus natural history and co-detection with alphapapillomavirus in cervical samples of adult women

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMALAGON, Talia
dc.contributor.authorRIBEIRO, Aline Lopes
dc.contributor.authorNUNES, Emily Montosa
dc.contributor.authorGHEIT, Tarik
dc.contributor.authorEL-ZEIN, Mariam
dc.contributor.authorVILLA, Luisa L.
dc.contributor.authorFRANCO, Eduardo L.
dc.contributor.authorSICHERO, Laura
dc.date.accessioned2024-02-15T14:40:46Z
dc.date.available2024-02-15T14:40:46Z
dc.date.issued2023
dc.description.abstractHuman papillomaviruses (HPV) of the genus Betapapillomavirus can infect both cutaneous and mucosal sites, but research on their natural history at mucosal sites remains scarce. We examined the risk factors and co-detection patterns of HPVs of the Betapapillomavirus and Alphapapillomavirus genera in cervical samples of the Ludwig-McGill cohort study. We assessed a subset of 505 women from the Ludwig-McGill cohort study from Sao Paulo, Brazil. Cervical samples over the first year of follow-up were tested for DNA of over 40 alphapapillomavirus types and 43 betapapillomavirus types using a type-specific multiplex genotyping polymerase chain reaction assay. We assessed the risk factors for prevalent and incident betapapillomavirus type detection, and whether types were detected more frequently together than expected assuming independence using permutation tests, logistic regression, and Cox regression. We observed significant within-genus clustering but not cross-genus clustering. Multiple betapapillomavirus types were co-detected in the same sample 2.24 (95% confidence interval [CI]: 1.65-3.29) times more frequently than expected. Conversely, co-detections of alphapapillomavirus and betapapillomavirus types in the same sample occurred only 0.64 (95% CI: 0.51-0.83) times as often as expected under independence. In prospective analyses, positivity to one HPV genus was associated with a nonsignificant lower incidence of detection of types in the other genus. Lifetime number of sex partners and new sex partner acquisition were associated with lower risks of prevalent and incident betapapillomavirus detection. Betapapillomaviruses are commonly found in the cervicovaginal tract. Results suggest potentially different mechanisms of transmission for betapapillomavirus genital infections other than vaginal sex.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipLudwig Institute for Cancer Research
dc.description.sponsorshipU.S. National Cancer Institute [CA70269]
dc.description.sponsorshipCanadian Institutes of Health Research [MA-13647, MOP-49396, CRN-83320]
dc.identifier.citationJOURNAL OF MEDICAL VIROLOGY, v.95, n.12, article ID e29288, 11p, 2023
dc.identifier.doi10.1002/jmv.29288
dc.identifier.eissn1096-9071
dc.identifier.issn0146-6615
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57910
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Medical Virology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectepidemiologyeng
dc.subjecthuman papillomaviruseng
dc.subjectresearch and analysis methodseng
dc.subjectsexually transmitted diseaseeng
dc.subject.otherpapillomavirus hpv typeseng
dc.subject.othercutaneous betaeng
dc.subject.othercoinfectioneng
dc.subject.otherprevalenceeng
dc.subject.otherinfectioneng
dc.subject.othermucosaleng
dc.subject.otherlesionseng
dc.subject.othercancereng
dc.subject.othersiteseng
dc.subject.otherriskeng
dc.subject.wosVirologyeng
dc.titleBetapapillomavirus natural history and co-detection with alphapapillomavirus in cervical samples of adult womeneng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryCanadá
hcfmusp.affiliation.countryFrança
hcfmusp.affiliation.countryisoca
hcfmusp.affiliation.countryisofr
hcfmusp.author.externalMALAGON, Talia:McGill Univ, Gerald Bronfman Dept Oncol, Div Canc Epidemiol, Montreal, PQ, Canada; Montreal West Isl Integrated Univ Hlth & Social Se, St Marys Res Ctr, Montreal, PQ, Canada; McGill Univ, Div Canc Epidemiol, 5100 Maisonneuve Blvd,Suite 720, Montreal, PQ H4A 3T2, Canada
hcfmusp.author.externalNUNES, Emily Montosa:Univ Sao Paulo FMUSP HC, Hosp Clin, Ctr Translat Res Oncol, Fac Med,Inst Canc Estado Sao Paulo ICESP, Sao Paulo, Brazil
hcfmusp.author.externalGHEIT, Tarik:Int Agcy Canc Res IARC, Epigen & Mech Branch, Lyon, France
hcfmusp.author.externalEL-ZEIN, Mariam:McGill Univ, Gerald Bronfman Dept Oncol, Div Canc Epidemiol, Montreal, PQ, Canada
hcfmusp.author.externalFRANCO, Eduardo L.:McGill Univ, Gerald Bronfman Dept Oncol, Div Canc Epidemiol, Montreal, PQ, Canada
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcALINE LOPES RIBEIRO
hcfmusp.contributor.author-fmusphcLUISA LINA VILLA
hcfmusp.contributor.author-fmusphcLAURA CRISTINA SICHERO VETTORAZZO
hcfmusp.description.articlenumbere29288
hcfmusp.description.issue12
hcfmusp.description.volume95
hcfmusp.origemWOS
hcfmusp.origem.pubmed38054528
hcfmusp.origem.scopus2-s2.0-85178850412
hcfmusp.origem.wosWOS:001138650800014
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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hcfmusp.scopus.lastupdate2024-05-17
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