Impact of Inflammation and Treatment on Self-reported Quality of Life in Patients with Non-acute Vogt-Koyanagi-Harada Disease (VKHD)

Imagem de Miniatura
Arquivos
art_SOUTO_Impact_of_Inflammation_and_Treatment_on_Selfreported_Quality_2021.PDF (540.46 KB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2021
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
TAYLOR & FRANCIS INC
Autores
SAKATA, Viviane Mayumi
Citação
OCULAR IMMUNOLOGY AND INFLAMMATION, v.29, n.1, p.137-148, 2021
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aims: To evaluate associations between vision-related (VR-) and health-related (HR-) QoL metrics and inflammation and treatment in non-acute VKHD patients. Methods: Cross-sectional study in a tertiary center in Sao Paulo, Brazil with 22 patients with non-acute VKHD followed prospectively for >= 12 months since acute disease onset, with systematic evaluation and predefined treatment protocols. VR- and HR-QoL aspects were assessed by VFQ-25 and SF-36 questionnaires, respectively. Associations between the questionnaire's subscale item scores with inflammation and systemic medical therapies were assessed. Results: After generalized linear model analysis, worse VA, severe fundus changes, fluctuation of VA and fluctuation of anterior chamber cells impacted negatively on VR-QoL items. Higher cumulative total dose of corticosteroids and use of immunosuppressive therapy impacted negatively on both questionnaires. Conclusion: Worse VA, clinical inflammation and systemic treatment have a significant impact on VR- and HR-QoL questionnaires. Subclinical choroidal inflammation did not seem to impact QoL.
Palavras-chave
Inflammation, quality of life, treatment medical, uveitis, uveomeningoencephalitic syndrome
URI
https://observatorio.fm.usp.br/handle/OPI/40104
Referências
  1. Ciconelli RM, 1997, THESIS
  2. da Silva FT, 2009, AM J OPHTHALMOL, V148, P939, DOI 10.1016/j.ajo.2009.06.029
  3. Du LP, 2016, PROG RETIN EYE RES, V52, P84, DOI 10.1016/j.preteyeres.2016.02.002
  4. Gardiner AM, 2002, BRIT J OPHTHALMOL, V86, P993, DOI 10.1136/bjo.86.9.993
  5. Haasnoot AMJW, 2017, ARTHRIT CARE RES, V69, P1895, DOI 10.1002/acr.23224
  6. Herbort Carl P., 2007, International Ophthalmology, V27, P173, DOI 10.1007/s10792-007-9060-y
  7. Herbort CP, 2019, INT OPHTHALMOL, V39, P1419, DOI 10.1007/s10792-018-0949-4
  8. Herbort CP, 2017, INT OPHTHALMOL, V37, P1383, DOI 10.1007/s10792-016-0395-0
  9. Hoeksema L, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0146956
  10. Hui MM, 2017, OCUL IMMUNOL INFLAMM, V25, P486, DOI 10.3109/09273948.2016.1139734
  11. Kaleemunnisha S, 2014, MIDDLE EAST AFR J OP, V21, P225, DOI 10.4103/0974-9233.134675
  12. Kappel PJ, 2009, AM J OPHTHALMOL, V147, P351, DOI 10.1016/j.ajo.2008.08.021
  13. Kuiper JJW, 2013, ACTA OPHTHALMOL, V91, pE329, DOI 10.1111/aos.12054
  14. Lavezzo MM, 2016, ORPHANET J RARE DIS, V11, DOI 10.1186/s13023-016-0412-4
  15. Lescrauwaet B, 2017, INVEST OPHTH VIS SCI, V58, P3555, DOI 10.1167/iovs.17-22049
  16. Mangione CM, 2001, ARCH OPHTHALMOL-CHIC, V119, P1050, DOI 10.1001/archopht.119.7.1050
  17. MARMOR MF, 1986, BRIT J OPHTHALMOL, V70, P553, DOI 10.1136/bjo.70.7.553
  18. McCulloch DL, 2015, DOC OPHTHALMOL, V130, P1, DOI 10.1007/s10633-014-9473-7
  19. Miserocchi E, 2010, OCUL IMMUNOL INFLAMM, V18, P297, DOI 10.3109/09273941003637510
  20. Missaka R., 2019, OCUL IMMUNOL INFLAMM, V28, P1
  21. MOORTHY RS, 1995, SURV OPHTHALMOL, V39, P265, DOI 10.1016/S0039-6257(05)80105-5
  22. Murphy CC, 2005, BRIT J OPHTHALMOL, V89, P1161, DOI 10.1136/bjo.2005.067421
  23. Murphy CC, 2007, BRIT J OPHTHALMOL, V91, P154, DOI 10.1136/bjo.2006.105528
  24. Niemeyer KM, 2017, AM J OPHTHALMOL, V179, P10, DOI 10.1016/j.ajo.2017.04.003
  25. Read RW, 2001, AM J OPHTHALMOL, V131, P647, DOI 10.1016/S0002-9394(01)00925-4
  26. Sakai T, 2013, BRIT J OPHTHALMOL, V97, P338, DOI 10.1136/bjophthalmol-2012-302515
  27. Sakata VM, 2014, AUTOIMMUN REV, V13, P550, DOI 10.1016/j.autrev.2014.01.023
  28. Schiffman RM, 2001, ARCH OPHTHALMOL-CHIC, V119, P841
  29. Shah KH, 2006, AM J OPHTHALMOL, V142, P284, DOI 10.1016/j.ajo.2006.03.046
  30. Simao LM, 2008, ARQ BRAS OFTALMOL, V71, P540, DOI 10.1590/S0004-27492008000400014
  31. Tagawa Y, 2015, BR J OPHTHALMOL, V1, P1
  32. Tugal-Tutkun Ilknur, 2010, International Ophthalmology, V30, P539, DOI 10.1007/s10792-008-9263-x
  33. Venugopal V, 2017, OPHTHALMOLOGY, V124, P1
  34. Ware J.E., 1993, SF 36 PHYS MENTAL HL

Coleções
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/33