Atopic dermatitis: correlation between non-damaged skin barrier function and disease activity

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorADDOR, Flavia A. S.
dc.contributor.authorTAKAOKA, Roberto
dc.contributor.authorRIVITTI, Evandro A.
dc.contributor.authorAOKI, Valeria
dc.date.accessioned2013-07-30T14:43:47Z
dc.date.available2013-07-30T14:43:47Z
dc.date.issued2012
dc.description.abstractBackground Atopic dermatitis (AD) is a chronic dermatosis, predominant in childhood, characterized by pruritus and eczematous-type lesions with xerosis as the prominent clinical sign. Objectives To analyze the correlation between biophysical measurements of skin barrier function and other assessment criteria of clinical severity according to Rajka and Langelands criteria. Methods Biophysical measurements [transepidermal water loss (TEWL) and corneometry] were obtained from 120 patients with the diagnosis of AD. Serum levels of IgE were also evaluated. Results A significant correlation between corneometry, TEWL, and clinical severity of AD was found. Data showed an inverse correlation between corneometry, TEWL, and AD severity, and a significant difference (P < 0.001) between mean of corneometry and TEWL and AD severity (mild, moderate, and severe). As for IgE levels, corneometry had significant negative correlation, in contrast with TEWL, which showed a significant positive correlation (P < 0.001). Conclusion Biophysical measurements of skin barrier in non-lesional skin of AD may work as an evaluation factor for AD severity.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL JOURNAL OF DERMATOLOGY, v.51, n.6, p.672-676, 2012
dc.identifier.doi10.1111/j.1365-4632.2011.05176.x
dc.identifier.issn0011-9059
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/561
dc.language.isoeng
dc.publisherWILEY-BLACKWELL
dc.relation.ispartofInternational Journal of Dermatology
dc.rightsrestrictedAccess
dc.rights.holderCopyright WILEY-BLACKWELL
dc.subject.otherstratum-corneum hydration
dc.subject.othertransepidermal water-loss
dc.subject.othercontact-dermatitis
dc.subject.otherseverity
dc.subject.otherchildren
dc.subject.othereczema
dc.subject.otherage
dc.subject.otherdry
dc.subject.otherph
dc.subject.wosDermatology
dc.titleAtopic dermatitis: correlation between non-damaged skin barrier function and disease activity
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalADDOR, Flavia A. S.:Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo, Brazil
hcfmusp.citation.scopus43
hcfmusp.contributor.author-fmusphcROBERTO TAKAOKA
hcfmusp.contributor.author-fmusphcEVANDRO ARARIGBOIA RIVITTI
hcfmusp.contributor.author-fmusphcVALERIA AOKI
hcfmusp.description.beginpage672
hcfmusp.description.endpage676
hcfmusp.description.issue6
hcfmusp.description.volume51
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22607284
hcfmusp.origem.scopus2-s2.0-84861313381
hcfmusp.origem.wosWOS:000304253800006
hcfmusp.publisher.cityHOBOKEN
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-17
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