Low sodium intake is associated with low birth weight and size only when given in the second half of gestation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSIQUEIRA, Flavia Ramos de
dc.contributor.authorSOUZA, Regiane Machado de
dc.contributor.authorOLIVEIRA, Ivone Braga de
dc.contributor.authorFURUKAWA, Luzia Naoko S.
dc.contributor.authorHEIMANN, Joel Claudio
dc.date.accessioned2013-10-11T21:16:42Z
dc.date.available2013-10-11T21:16:42Z
dc.date.issued2012
dc.description.abstractThis study examined the effects of maternal low sodium intake during different periods of pregnancy on dams and male (M) and female (F) offspring. Methods: Female Wistar rats (n= 6 - 8/group) were fed low (LS - 0.15%) or normal (NS - 1.3% NaCl) sodium diet since the 1st day of gestation until delivery or LS during the 1st (LS10) or 2nd half of gestation (LS20). Results: (mean±SEM, p< 0.05): Maternal body weight (g) was lower in LS and LS20 than in NS and LS10 at the 3rd week of gestation (LS = 380±8.1; LS20 = 406±13.2; NS = 435±6.1, LS10 = 461±12.9). No difference was found in water and food intake among the groups. Also, no differences were observed in the litter size among experimental groups and no correlation betweenthe number of pups and maternal body weight at the 3rd week of gestation. At birth, body weight (g, n=14 to 27/group) (M: NS = 6.5±0.1, LS = 5.5±0.1, LS10 = 6.1±0.1, LS20 =4.8±0.1,F:NS = 6.1±0.2, LS = 5.2±0.1, LS10 = 5.6±0.1, LS20 = 4.1±0.1) and naso-anal length (cm, n=14 to 27) (M: NS = 5.1±0.02, LS = 4.9±0.03, LS10 = 5.0±0.03, LS20 = 4.6±0.03, F: NS =4.9±0.05,LS = 4.8±0.04, LS10 = 4.9±0.03, LS20 = 4.4±0.03) were lower in LS and LS20 than in NS offspring. Conclusion: Although maternal dietary intake was not influenced by dietary sodium content, maternal low sodium diet during the second half of gestation induced lower birth weight and size.
dc.description.conferencedateAPR 21-25, 2012
dc.description.conferencelocalSan Diego - CA, EUA
dc.description.conferencenameExperimental Biology Meeting
dc.description.indexMEDLINE
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifier.citationFASEB JOURNAL, v.26, 2012
dc.identifier.issn0892-6638
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2736
dc.language.isoeng
dc.publisherFEDERATION AMER SOC EXP BIOL
dc.relation.ispartofFaseb Journal
dc.rightsrestrictedAccess
dc.rights.holderCopyright FEDERATION AMER SOC EXP BIOL
dc.subject.wosBiochemistry & Molecular Biology
dc.subject.wosBiology
dc.subject.wosCell Biology
dc.titleLow sodium intake is associated with low birth weight and size only when given in the second half of gestation
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSOUZA, Regiane Machado de:Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
hcfmusp.contributor.author-fmusphcFLAVIA RAMOS DE SIQUEIRA
hcfmusp.contributor.author-fmusphcIVONE BRAGA DE OLIVEIRA
hcfmusp.contributor.author-fmusphcLUZIA NAOKO SHINOHARA FURUKAWA
hcfmusp.contributor.author-fmusphcJOEL CLAUDIO HEIMANN
hcfmusp.description.volume26
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000310711305001
hcfmusp.publisher.cityBETHESDA
hcfmusp.publisher.countryUSA
hcfmusp.remissive.sponsorshipCAPES
hcfmusp.remissive.sponsorshipFAPESP
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relation.isAuthorOfPublication8d0f7453-8c51-4c98-85b4-871fdc959dc1
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relation.isAuthorOfPublication.latestForDiscovery33718f5a-0eb5-44a7-bbd4-aaf93cc3e505
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