Cytomegalovirus colitis in immunocompetent critically ill patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSICILIANO, Rinaldo F.
dc.contributor.authorCASTELLI, Jussara B.
dc.contributor.authorRANDI, Bruno A.
dc.contributor.authorVIEIRA, Ricardo D.
dc.contributor.authorSTRABELLI, Tania M. V.
dc.date.accessioned2014-09-30T14:56:17Z
dc.date.available2014-09-30T14:56:17Z
dc.date.issued2014
dc.description.abstractObjectives: Cytomegalovirus (CMV) is a ubiquitous virus and its reactivation may lead to CMV end-organ disease ( CMV EOD) in immunocompromised patients and also in immunocompetent patients when they are critically ill. We aimed to investigate the frequency and the clinical features of proven CMV EOD in previously non-immunosuppressed patients admitted to our institution. Methods: From January 2000 to March 2013, the records of all patients with a histopathological diagnosis of CMV EOD at our teaching hospital were reviewed retrospectively. CMV EOD was diagnosed histologically by the identification of true cytomegalic viral inclusion involving endothelial, stromal, and/or epithelial cells on hematoxylin and eosin staining, and was subsequently confirmed by immunohistochemistry using specific antibody against CMV antigens. Immunocompromised patients were excluded. Results: CMV EOD manifesting as colitis was diagnosed in 14 previously immunocompetent intensive care unit (ICU) patients. The mean age of the patients was 64 years. All had co-morbidities and developed shock before CMV EOD. The major manifestation was gastrointestinal bleeding. The in-hospital mortality rate was 71.4% despite specific treatment with ganciclovir. Conclusions: Despite being a rare condition, lower gastrointestinal bleeding in this profile of ICU patients could be the clinical manifestation of CMV colitis, and intensivists should be alert to this condition.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.20, p.71-73, 2014
dc.identifier.doi10.1016/j.ijid.2013.11.008
dc.identifier.eissn1878-3511
dc.identifier.issn1201-9712
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/7816
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.rightsopenAccess
dc.rights.holderCopyright ELSEVIER SCI LTD
dc.subjectCytomegalovirus
dc.subjectColitis
dc.subjectIntensive care
dc.subjectCritically ill
dc.subject.otherinfection
dc.subject.otherhosts
dc.subject.wosInfectious Diseases
dc.titleCytomegalovirus colitis in immunocompetent critically ill patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalVIEIRA, Ricardo D.:Univ Sao Paulo, Sch Med, Heart Inst InCor, Clin Cardiol Unit, BR-05403000 Sao Paulo, Brazil
hcfmusp.citation.scopus34
hcfmusp.contributor.author-fmusphcRINALDO FOCACCIA SICILIANO
hcfmusp.contributor.author-fmusphcJUSSARA BIANCHI CASTELLI
hcfmusp.contributor.author-fmusphcBRUNO AZEVEDO RANDI
hcfmusp.contributor.author-fmusphcTANIA MARA VAREJAO STRABELLI
hcfmusp.description.beginpage71
hcfmusp.description.endpage73
hcfmusp.description.volume20
hcfmusp.origemWOS
hcfmusp.origem.pubmed24406737
hcfmusp.origem.scopus2-s2.0-84895151068
hcfmusp.origem.wosWOS:000333565100015
hcfmusp.publisher.cityOXFORD
hcfmusp.publisher.countryENGLAND
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hcfmusp.scopus.lastupdate2024-05-10
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