Benznidazole Use among Patients with Chronic Chagas' Cardiomyopathy in an Endemic Region of Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorFERREIRA, Ariela Mota
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorOLIVEIRA, Lea Campos de
dc.contributor.authorOLIVEIRA, Claudia Di Lorenzo
dc.contributor.authorCARDOSO, Clareci Silva
dc.contributor.authorRIBEIRO, Antonio Luiz Pinho
dc.contributor.authorHAIKAL, Desiree Sant'Ana
dc.date.accessioned2017-02-16T12:44:46Z
dc.date.available2017-02-16T12:44:46Z
dc.date.issued2016
dc.description.abstractChagas disease (CD) is a neglected tropical disease that affects individuals in almost every country in Latin America. There are two available drugs with antiparasitic profiles; however, only benznidazole (BZN) has been approved for commercialization in Brazil. The usefulness of prescribing BZN for patients with chronic Chagas cardiomyopathy (CCC) is controversial. There are no studies in the literature describing the extent of BZN use at this stage or the profile of patients using this drug. The present study aimed to determine the prevalence and factors associated with previous BZN use among individuals with CCC. This cross-sectional study was conducted with 1,812 individuals with CCC from 21 Brazilian cities endemic for CD. The dependent variable was ""prior use of BZN"" (no vs. yes). The independent variables were grouped into socioeconomic, lifestyle and medical history aspects. Binary logistic regression (alpha >= 0.05) was used. Among the evaluated individuals, 27.2% reported previous use of BZN. The likelihood of prior use of BZN was higher among younger individuals (OR = 2.7), individuals with a higher education (OR = 2.7), individuals with a lower monthly per capita income (OR = 1.3), individuals who practiced physical exercise (OR = 1.5), individuals who had prior knowledge of the CD diagnosis (OR = 2.5), individuals without hypertension (OR = 1.3) and individuals with a longer time to the CD diagnosis (OR = 6.1). The present study revealed a small proportion of therapeutic BZN use among Brazilian CCC patients. This finding suggests a late diagnosis and undertreatment of the disease. BZN use was higher among individuals with better clinical and demographic conditions but with a lower income and a longer time to the CD diagnosis. Knowledge of the BZN usage profile may help reduce the current state of neglect of this disease and pave the way for future studies.
dc.description.indexMEDLINE
dc.description.sponsorshipNational Institutes of Health [P50AI098461]
dc.identifier.citationPLOS ONE, v.11, n.11, article ID e0165950, 13p, 2016
dc.identifier.doi10.1371/journal.pone.0165950
dc.identifier.issn1932-6203
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17903
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCE
dc.relation.ispartofPlos One
dc.rightsopenAccess
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCE
dc.subject.otherdisease
dc.subject.othereducation
dc.subject.otherpopulation
dc.subject.otherknowledge
dc.subject.othermalaria
dc.subject.otherbolivia
dc.subject.otherfuture
dc.subject.othertrial
dc.subject.wosMultidisciplinary Sciences
dc.titleBenznidazole Use among Patients with Chronic Chagas' Cardiomyopathy in an Endemic Region of Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalFERREIRA, Ariela Mota:Univ Estadual Montes Claros, Grad Program Hlth Sci, Montes Claros, MG, Brazil
hcfmusp.author.externalOLIVEIRA, Claudia Di Lorenzo:Fed Univ Sao Joao del Rey, Res Grp Epidemiol & New Technol Hlth Campus CCO, Sao Joao Del Rei, Brazil
hcfmusp.author.externalCARDOSO, Clareci Silva:Fed Univ Sao Joao del Rey, Res Grp Epidemiol & New Technol Hlth Campus CCO, Sao Joao Del Rei, Brazil
hcfmusp.author.externalRIBEIRO, Antonio Luiz Pinho:Univ Fed Minas Gerais, Dept Internal Med, Belo Horizonte, MG, Brazil
hcfmusp.author.externalHAIKAL, Desiree Sant'Ana:Univ Estadual Montes Claros, Grad Program Hlth Sci, Montes Claros, MG, Brazil
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.contributor.author-fmusphcLEA CAMPOS DE OLIVEIRA
hcfmusp.description.articlenumbere0165950
hcfmusp.description.issue11
hcfmusp.description.volume11
hcfmusp.origemWOS
hcfmusp.origem.pubmed27855177
hcfmusp.origem.scopus2-s2.0-84995639458
hcfmusp.origem.wosWOS:000387910200014
hcfmusp.publisher.citySAN FRANCISCO
hcfmusp.publisher.countryUSA
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