Intracellular peptides in SARS-CoV-2-infected patients

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art_MARTUCCI_Intracellular_peptides_in_SARSCoV2infected_patients_2023.PDF (4.31 MB)
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0
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CELL PRESS
Autores
MARTUCCI, Luiz Felipe
EICHLER, Rosangela A. S.
SILVA, Renee N. O.
COSTA, Tiago J.
TOSTES, Rita C.
Citação
ISCIENCE, v.26, n.9, article ID 107542, 17p, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Intracellular peptides (InPeps) generated by the orchestrated action of the proteasome and intracellular peptidases have biological and pharmacological sig-nificance. Here, human plasma relative concentration of specific InPeps was compared between 175 patients infected with severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2), and 45 SARS-CoV-2 non-infected patients; 2,466 unique peptides were identified, of which 67% were InPeps. The results re-vealed differences of a specific group of peptides in human plasma comparing non-infected individuals to patients infected by SARS-CoV-2, following the re-sults of the semi-quantitative analyses by isotope-labeled electrospray mass spectrometry. The protein-protein interactions networks enriched pathways, drawn by genes encoding the proteins from which the peptides originated, re-vealed the presence of the coronavirus disease/COVID-19 network solely in the group of patients fatally infected by SARS-CoV-2. Thus, modulation of the rela-tive plasma levels of specific InPeps could be employed as a predictive tool for disease outcome.
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URI
https://observatorio.fm.usp.br/handle/OPI/56169
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
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