Maternal allergen immunization in mice: Prevention of offspring early allergen sensitization

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorVICTOR, J. R.
dc.contributor.authorOLIVEIRA, L. M.
dc.contributor.authorLIRA, A. A. L.
dc.contributor.authorMUNIZ, B. P.
dc.contributor.authorDUARTE, A. J. S.
dc.contributor.authorSATO, M. N.
dc.date.accessioned2013-10-11T21:25:48Z
dc.date.available2013-10-11T21:25:48Z
dc.date.issued2013
dc.description.abstractBackground: Previously we have been observed that pre-conceptional maternal immunization to OVA is able to prevent the development of allergy in mice. Methods: Female mice were immunized with OVA and mated with normal males. Offspring were evaluated at 3 days old (d.o.) or immunized with OVA and evaluated at 20 d.o. Results: Maternal immunization up-regulated the expression of FcγRIIb on offspring B cells at 3 and 20 d.o. Serum analysis revealed a down regulation on offspring IL-6 levels. Newborns show similar levels of TCD4+ cells producing IL-10, IL-17, IFN-γ or IL-4. Offspring from immune-mothers shows augmented IL-10+ and IL-17+ B cell levels. After offspring immunization we observed higher levels of IL-17+ and IFN-γ+ TCD4+ cells and IL-17+ and IFN-γ+ B cells of offspring from immune mothers. Conclusion: We confirmed the up-regulation of FcγRIIb on offspring B cells, and the augmented IL-10+ B cells on offspring suggest Breg cells involvement. The role of IL-17 must be investigated.
dc.description.conferencedateFEB 18-20, 2013
dc.description.conferencelocalFoz do Iguacu, BRAZIL
dc.description.conferencename5th Latin American Symposium on Maternal Fetal Interaction and Placenta (SLIMP) / 4th Latin American Symposium on Reproductive Immunology (LASRI)
dc.description.indexMEDLINE
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade de São Paulo, Faculdade de Medicina, Hospital da Clínicas, Laboratório de Investigação em Dermatologia e Imunodeficiências [FMUSP-HC/LIM-56]
dc.identifier.citationPLACENTA, v.34, n.2, p.A17-A17, 2013
dc.identifier.issn0143-4004
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/3037
dc.language.isoeng
dc.publisherW B SAUNDERS CO LTD
dc.relation.ispartofPlacenta
dc.rightsrestrictedAccess
dc.rights.holderCopyright W B SAUNDERS CO LTD
dc.subject.wosDevelopmental Biology
dc.subject.wosObstetrics & Gynecology
dc.subject.wosReproductive Biology
dc.titleMaternal allergen immunization in mice: Prevention of offspring early allergen sensitization
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalOLIVEIRA, L. M.:Univ Sao Paulo, Lab Dermatol & Immunodeficiencies LIM56, Sch Med, BR-09500900 Sao Paulo, Brazil
hcfmusp.author.externalLIRA, A. A. L.:Univ Sao Paulo, Lab Dermatol & Immunodeficiencies LIM56, Sch Med, BR-09500900 Sao Paulo, Brazil
hcfmusp.author.externalMUNIZ, B. P.:Univ Sao Paulo, Lab Dermatol & Immunodeficiencies LIM56, Sch Med, BR-09500900 Sao Paulo, Brazil
hcfmusp.contributor.author-fmusphcJEFFERSON RUSSO VICTOR
hcfmusp.contributor.author-fmusphcALBERTO JOSE DA SILVA DUARTE
hcfmusp.contributor.author-fmusphcMARIA NOTOMI SATO
hcfmusp.description.beginpageA17
hcfmusp.description.endpageA17
hcfmusp.description.issue2
hcfmusp.description.volume34
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000314857100052
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFMUSP-HC
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relation.isAuthorOfPublication8e4f2c15-06a5-444b-826d-84576403144e
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relation.isAuthorOfPublication.latestForDiscovery3f9cbc83-dc25-45f8-92f6-0f2c6f6de420
Arquivos
Coleções
Comunicações em Eventos - FM/MPT
Comunicações em Eventos - FM/MDT
Comunicações em Eventos - HC/ICHC
Comunicações em Eventos - LIM/03
Comunicações em Eventos - LIM/56