Regional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorOLIVEIRA, Luciano Fonseca Lemos de
dc.contributor.authorTHACKERAY, James T.
dc.contributor.authorMARIN NETO, Jose Antonio
dc.contributor.authorROMANO, Minna Moreira Dias
dc.contributor.authorCARVALHO, Eduardo Elias Vieira de
dc.contributor.authorMEJIA, Jorge
dc.contributor.authorTANAKA, Denise Mayumi
dc.contributor.authorSILVA, Grace Kelly da
dc.contributor.authorABDALLA, Douglas Reis
dc.contributor.authorMALAMUT, Carlos
dc.contributor.authorBENGEL, Frank M.
dc.contributor.authorHIGUCHI, Maria de Lourdes
dc.contributor.authorSCHMIDT, Andre
dc.contributor.authorCUNHA-NETO, Edecio
dc.contributor.authorSIMOES, Marcus Vinicius
dc.date.accessioned2018-11-21T17:00:04Z
dc.date.available2018-11-21T17:00:04Z
dc.date.issued2018
dc.description.abstractAltered myocardial perfusion is a common finding in chronic Chagas cardiomyopathy (CCC), but its underlying histologic changes have not been elucidated. We investigated the occurrence of myocardial perfusion defects (MPDs) and the correlated regional changes to histology in an experimental model of CCC in hamsters. Methods: Female Syrian hamsters (n = 34) were infected with 3.5 x 10(4) to 10(5) trypomastigote forms of Trypanosoma cruzi, Y strain, and 6-10 mo afterward underwent in vivo imaging including resting Tc-99m-sestamibi SPECT, segmental and global left ventricular function assessment using 2-dimensional echocardiography, and F-18-FDG PET for evaluation of myocardial viability. Histologic analysis included quantification of fibrosis, inflammatory infiltration, and the diameter and density of myocardial microcirculation. Results: MPDs were present in 17 (50%) of the infected animals. Histologic analysis revealed no transmural scar in segments with an MPD, and normal or mildly reduced F-18-FDG uptake, indicating viable myocardium. Infected animals with an MPD, in comparison to infected animals without an MPD and control animals, showed a lower left ventricular ejection fraction (P = 0.012), a higher wall motion score index (P = 0.004), and a higher extent of inflammatory infiltration (P = 0.018) but a similar extent of fibrosis (P = 0.15) and similar microvascular diameter and density (P > 0.05). Segments with an MPD (n = 65), as compared with normally perfused regions in the same animal (n = 156), showed a higher wall motion score index (P = 0.005) but a similar extent of inflammatory infiltration, a similar extent of fibrosis, and a similar microvascular diameter and density. Conclusion: Resting MPDs are frequent in experimental CCC and are associated with myocardial inflammation but do not designate scar tissue, corresponding to regions with metabolically viable myocardium.
dc.description.indexMEDLINE
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2015/25209-5, 2011/03261-4]
dc.identifier.citationJOURNAL OF NUCLEAR MEDICINE, v.59, n.9, p.1430-1436, 2018
dc.identifier.doi10.2967/jnumed.117.205450
dc.identifier.eissn1535-5667
dc.identifier.issn0161-5505
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29343
dc.language.isoeng
dc.publisherSOC NUCLEAR MEDICINE INC
dc.relation.ispartofJournal of Nuclear Medicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright SOC NUCLEAR MEDICINE INC
dc.subjectchronic Chagas cardiomyopathy
dc.subjectmyocardial perfusion
dc.subjectmyocardial inflammation
dc.subject.othertrypanosoma-cruzi infection
dc.subject.otherheart-rate-variability
dc.subject.othermitochondrial dysfunction
dc.subject.otherdilated cardiomyopathy
dc.subject.otherdisease
dc.subject.otherpathogenesis
dc.subject.othermicrocirculation
dc.subject.otherabnormalities
dc.subject.otherf-18-fdg
dc.subject.otherspect
dc.subject.wosRadiology, Nuclear Medicine & Medical Imaging
dc.titleRegional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalOLIVEIRA, Luciano Fonseca Lemos de:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalTHACKERAY, James T.:Hannover Med Sch, Dept Nucl Med, Hannover, Germany
hcfmusp.author.externalMARIN NETO, Jose Antonio:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalROMANO, Minna Moreira Dias:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalCARVALHO, Eduardo Elias Vieira de:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalMEJIA, Jorge:Hosp Israelita Albert Einstein, Sao Paulo, Brazil
hcfmusp.author.externalTANAKA, Denise Mayumi:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalSILVA, Grace Kelly da:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalABDALLA, Douglas Reis:Fac Human Talent, Hlth Dept, Uberaba, Brazil
hcfmusp.author.externalMALAMUT, Carlos:Natl Commiss Nucl Energy CNEN, Nucl Technol Dev Ctr CDTN, Belo Horizonte, MG, Brazil
hcfmusp.author.externalBENGEL, Frank M.:Hannover Med Sch, Dept Nucl Med, Hannover, Germany
hcfmusp.author.externalSCHMIDT, Andre:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.author.externalSIMOES, Marcus Vinicius:Univ Sao Paulo, Med Sch Ribeirao Preto, 3900 Bandeirantes Ave, BR-14048900 Ribeirao Preto, SP, Brazil
hcfmusp.citation.scopus12
hcfmusp.contributor.author-fmusphcMARIA DE LOURDES HIGUCHI
hcfmusp.contributor.author-fmusphcEDECIO CUNHA NETO
hcfmusp.description.beginpage1430
hcfmusp.description.endpage1436
hcfmusp.description.issue9
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.pubmed29700129
hcfmusp.origem.scopus2-s2.0-85053179687
hcfmusp.origem.wosWOS:000443772500027
hcfmusp.publisher.cityRESTON
hcfmusp.publisher.countryUSA
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