Cardiovascular Interactions of Renin-Angiotensin-Aldosterone System Assessed by Cardiac Magnetic Resonance: The Multi-Ethnic Study of Atherosclerosis

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Citações na Scopus
1
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS
Autores
VARADARAJAN, Vinithra
MARQUES, Mateus D.
VENKATESH, Bharath Ambale
ALLISON, Matthew
OSTOVANEH, Mohammad R.
YONEYAMA, Kihei
DONEKAL, Sirisha
V, Ravi Shah
MURTHY, Venkatesh L.
WU, Colin O.
Citação
AMERICAN JOURNAL OF HYPERTENSION, v.36, n.9, p.517-523, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background The effects of the renin-angiotensin-aldosterone system in cardiovascular system have been described based on small studies. The aim of this study was to evaluate the relationship between aldosterone and plasma renin activity (PRA) and cardiovascular structure and function. Methods We studied a random sample of Multi-Ethnic Study of Atherosclerosis participants who had aldosterone and PRA blood assays at 2003-2005 and underwent cardiac magnetic resonance at 2010. Participants taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers were excluded. Results The aldosterone group was composed by 615 participants, mean age 61.6 +/- 8.9 years, while the renin group was 580 participants, mean age 61.5 +/- 8.8 years and both groups had roughly 50% females. In multivariable analysis, 1 SD increment of log-transformed aldosterone level was associated with 0.07 g/m(2) higher left ventricle (LV) mass index (P = 0.04) and 0.11 ml/m(2) higher left atrium (LA) minimal volume index (P < 0.01). Additionally, higher log-transformed aldosterone was associated with lower LA maximum strain and LA emptying fraction (P < 0.01). Aldosterone levels were not significantly associated with aortic measures. Log-transformed PRA was associated with lower LV end diastolic volume index (beta standardized = 0.08, P = 0.05). PRA levels were not significantly associated with LA and aortic structural or functional differences. Conclusions Higher levels of aldosterone and PRA are associated with concentric LV remodeling changes. Moreover, aldosterone was related to deleterious LA remodeling changes.
Palavras-chave
blood pressure, cardiac magnetic resonance imaging, hypertension, left atrium dysfunction, left ventricle remodeling, renin-angiotensin-aldosterone system, vascular remodeling
URI
https://observatorio.fm.usp.br/handle/OPI/57769
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Coleções
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - LIM/64