Abnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMARTIN, Patricia
dc.contributor.authorTEODORO, Walcy R.
dc.contributor.authorVELOSA, Ana Paula P.
dc.contributor.authorMORAIS, Jymenez de
dc.contributor.authorCARRASCO, Solange
dc.contributor.authorCHRISTMANN, Romy B.
dc.contributor.authorGOLDENSTEIN-SCHAINBERG, Claudia
dc.contributor.authorPARRA, Edwin R.
dc.contributor.authorKATAYAMA, Maria Lucia
dc.contributor.authorSOTTO, Mirian N.
dc.contributor.authorCAPELOZZI, Vera L.
dc.contributor.authorYOSHINARI, Natalino H.
dc.date.accessioned2013-07-30T14:43:49Z
dc.date.available2013-07-30T14:43:49Z
dc.date.issued2012
dc.description.abstractObjective: The physiological and mechanical properties of the skin, the primary tissue affected by systemic sclerosis, depend on the assembly of collagen types I, Ill and V, which form heterotypic fibers. Collagen V (COLV) regulates heterotypic fiber diameter, and the maintenance of its properties is important for maintaining normal tissue architecture and function. Based on a COLV-induced experimental SSc model, in which overexpression of abnormal COLV was a prominent feature, we assumed that this abnormality could be present in SSc patients and could be correlated to disease duration, skin thickening and disease activity. Methods: Skin biopsies from 18 patients (6 early-stage and 12 late-stage) and 10 healthy controls were studied. Skin thickening assessment was performed with the Modified Rodnan Skin Score (MRSS), and activity was calculated using the Valentini Disease Activity Index. Morphology, morphometry of COLV deposition in dermis, as well as, quantitative RT-PCR and 3D-reconstruction of the dermal fibroblast culture were performed. Results: Structurally abnormal COLV was overexpressed in SSc skin, mainly in the early stages of the disease, when compared to normal controls and late-stage. A positive correlation between COLV expression and MRSS and disease activity was observed. Collagen V alpha-1 and alpha-2 mRNA expression levels were higher in SSc. Tridimensional reconstruction of SSc dermal heterotypic fibers confirmed the presence of atypical COLV. Conclusion: Increased synthesis of abnormal COLV and its correlation with disease stage, activity and MRSS suggest that this collagen can be a possible trigger involved in the pathogenesis of SSc.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipFederico Foundation
dc.identifier.citationAUTOIMMUNITY REVIEWS, v.11, n.11, Special Issue, p.827-835, 2012
dc.identifier.doi10.1016/j.autrev.2012.02.017
dc.identifier.issn1568-9972
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/569
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.relation.ispartofAutoimmunity Reviews
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE BV
dc.subjectSystemic sclerosis
dc.subjectType V collagen
dc.subjectSkin
dc.subjectModified Rodnan Skin Score
dc.subjectValentini Disease Activity Index
dc.subject.otherlung allograft-rejection
dc.subject.otherbreast-cancer cells
dc.subject.otherbronchiolitis obliterans
dc.subject.otherpulmonary-fibrosis
dc.subject.otherexperimental-model
dc.subject.othernasal tolerance
dc.subject.otheroral tolerance
dc.subject.othergrowth-factor
dc.subject.othert-cells
dc.subject.otherscleroderma
dc.subject.wosImmunology
dc.titleAbnormal collagen V deposition in dermis correlates with skin thickening and disease activity in systemic sclerosis
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalCHRISTMANN, Romy B.:Boston Univ, Sch Med, Boston, MA 02118 USA
hcfmusp.citation.scopus47
hcfmusp.contributor.author-fmusphcPATRICIA MARTIN
hcfmusp.contributor.author-fmusphcWALCY PAGANELLI ROSOLIA TEODORO
hcfmusp.contributor.author-fmusphcANA PAULA PEREIRA VELOSA
hcfmusp.contributor.author-fmusphcJYMENEZ DE MORAIS
hcfmusp.contributor.author-fmusphcSOLANGE CARRASCO
hcfmusp.contributor.author-fmusphcCLAUDIA GOLDENSTEIN SCHAINBERG
hcfmusp.contributor.author-fmusphcEDWIN ROGER PARRA CUENTAS
hcfmusp.contributor.author-fmusphcMARIA LUCIA HIRATA KATAYAMA
hcfmusp.contributor.author-fmusphcMIRIAN NACAGAMI SOTTO
hcfmusp.contributor.author-fmusphcVERA LUIZA CAPELOZZI
hcfmusp.contributor.author-fmusphcNATALINO HAJIME YOSHINARI
hcfmusp.description.beginpage827
hcfmusp.description.endpage835
hcfmusp.description.issue11
hcfmusp.description.issueSpecial Issue
hcfmusp.description.volume11
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed22406224
hcfmusp.origem.scopus2-s2.0-84865356287
hcfmusp.origem.wosWOS:000308837500015
hcfmusp.publisher.cityAMSTERDAM
hcfmusp.publisher.countryNETHERLANDS
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hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipFederico Foundation
hcfmusp.scopus.lastupdate2024-05-10
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