Pain paths among post-COVID-19 condition subjects: A prospective cross-sectional study with in-person evaluation

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKUBOTA, Gabriel T.
dc.contributor.authorSOARES, Felipe H. C.
dc.contributor.authorFONSECA, Alessandra S. da
dc.contributor.authorROSA, Talita dos Santos
dc.contributor.authorSILVA, Valquiria A. da
dc.contributor.authorGOUVEIA, Gisele R.
dc.contributor.authorFARIA, Viviane G.
dc.contributor.authorCUNHA, Pedro H. M. da
dc.contributor.authorBRUNONI, Andre R.
dc.contributor.authorTEIXEIRA, Manoel J.
dc.contributor.authorANDRADE, Daniel C. de
dc.date.accessioned2023-06-21T14:06:07Z
dc.date.available2023-06-21T14:06:07Z
dc.date.issued2023
dc.description.abstractBackgroundNew-onset chronic pain has been acknowledged as part of the post-COVID-19 condition. However, available fine-grained data about its clinical phenotype, trajectories and main associated characteristics remain scarce. We described the distinct temporal evolutions of post-COVID-19 pain and their epidemiological and phenotypical features. MethodsA prospective cross-sectional study enrolled post-COVID-19 condition patients (i.e. who had persisting COVID-19-related symptoms over 30 days since their first positive laboratory test), whose COVID-19 diagnosis had been supported by RT-PCR of oral/nasopharyngeal swab or serology. They underwent in-person evaluations with a structured interview, pain and quality-of-life-related questionnaires and thorough physical examination. Chronic pain (CP) and probable neuropathic pain (NP) were defined according to IASP criteria. ResultsThe present study included 226 individuals, 177 (78.3%) of whom presented over 3 months since their first COVID-19 symptom. New-onset pain occurred in 170 (75.2%) participants and was chronic in 116 (68.2%). A chronic course was associated with COVID-19-related hospitalization, new-onset fatigue, lower cognitive performance, motor and thermal sensory deficits, mood and sleep impairments and overall lower quality-of-life levels. Probable NP occurred in only 7.6% new-onset pain patients, and was associated with pain chronification, new-onset fatigue, motor and thermal sensory deficits, mechanical allodynia and lower rates of SARS-CoV-2 vaccination. Previous CP was reported by 86 (38.1%) individuals and had aggravated after the infection in 66 (76.7%) of them, which was associated with orthostatic hypotension. ConclusionsPost-COVID pain phenomena follow different paths, which are associated with specific clinical and epidemiological features, and possibly distinct underlying mechanisms, prognostic and therapeutic implications. SignificanceCOVID-19-related pain usually follows a chronic course and is non-neuropathic. Its possible courses and phenotypes are associated with distinct clinical and epidemiological features. This suggests differing underlying mechanisms, which may have significant prognostic and therapeutic implications.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationEUROPEAN JOURNAL OF PAIN, v.27, n.5, p.636-650, 2023
dc.identifier.doi10.1002/ejp.2094
dc.identifier.eissn1532-2149
dc.identifier.issn1090-3801
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/53770
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofEuropean Journal of Pain
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright WILEYeng
dc.subject.otherneuropathic paineng
dc.subject.othervalidationeng
dc.subject.othercovid-19eng
dc.subject.otherinventoryeng
dc.subject.othereq-5d-3leng
dc.subject.wosAnesthesiologyeng
dc.subject.wosClinical Neurologyeng
dc.subject.wosNeuroscienceseng
dc.titlePain paths among post-COVID-19 condition subjects: A prospective cross-sectional study with in-person evaluationeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcGABRIEL TARICANI KUBOTA
hcfmusp.contributor.author-fmusphcFELIPE HENRIQUES CARVALHO SOARES
hcfmusp.contributor.author-fmusphcALESSANDRA SANTOS DA FONSECA
hcfmusp.contributor.author-fmusphcTALITA DOS SANTOS ROSA
hcfmusp.contributor.author-fmusphcVALQUIRIA APARECIDA DA SILVA
hcfmusp.contributor.author-fmusphcGISELE RODRIGUES GOUVEIA
hcfmusp.contributor.author-fmusphcVIVIANE GENTIL FARIA
hcfmusp.contributor.author-fmusphcPEDRO HENRIQUE MARTINS DA CUNHA
hcfmusp.contributor.author-fmusphcANDRE RUSSOWSKY BRUNONI
hcfmusp.contributor.author-fmusphcMANOEL JACOBSEN TEIXEIRA
hcfmusp.contributor.author-fmusphcDANIEL CIAMPI ARAUJO DE ANDRADE
hcfmusp.description.beginpage636
hcfmusp.description.endpage650
hcfmusp.description.issue5
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.pubmed36799447
hcfmusp.origem.scopus2-s2.0-85150378397
hcfmusp.origem.wosWOS:000943586300001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
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Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - COVID-19
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
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