Chikungunya in kidney transplant recipients: A series of cases
Carregando...
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2017
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCI LTD
Citação
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.64, p.96-99, 2017
Resumo
Chikungunya (CHIK) is a mosquito-borne virus (CHIKV) infection that recently appeared in the Americas and thousands of confirmed cases have been reported in Brazil since the first autochthonous cases were reported in September 2014. We reported four cases of CHIK in kidney transplant recipients. The diagnosis was confirmed by positive CHIKV real-time polymerase chain reaction in two cases and positive CHIKV-IgM serology in two patients. The time between transplantation and CHIKV infection ranged from 2 to 11 years. All of them had arthralgia, and 3 of them had fever. Other symptoms were mild conjunctivitis, rash, and retro-orbital pain. Kidney function remained stable in all cases. In three patients prednisone doses were temporally increased and the symptoms disappeared concurrently with the increase of the dose. As for the fourth patient, the prednisone dose remained unchanged and yet she improved. Other immunosuppressive drugs were not changed for the four cases. As far as we know, there are only two previously reported cases of CHIK among solid organ transplant recipients besides the four cases reported here. Despite the small number of cases, we can speculate that the use of immunosuppression might have played a role in the paucity of symptoms and the gradual complete recovery with no complication. (C) 2017 The Authors.
Palavras-chave
Chikungunya, Kidney transplantation, Arboviruses, Immunossupression
Referências
- Arroyo-Avila M, 2015, P R HEALTH SCI J, V34, P71
- Brazil. Secretaria de Vigilancia em Saude. Ministerio da Saude, 2016, BRAZ SECR VIG SAUD B, V47
- Brazil. Secretaria de Vigilancia em Saude. Ministerio da Saude, 2015, BRAZ SECR VIG SAUD B, V46
- Caglioti C, 2013, NEW MICROBIOL, V36, P211
- Collucci C, 2016, BMJ-BRIT MED J, V354, DOI 10.1136/bmj.i4560
- Costa-da-Silva AL, 2017, PLOS NEGLECT TROP D, V11, DOI 10.1371/journal.pntd.0005630
- Azevedo RDD, 2015, REV SAUDE PUBL, V49, DOI 10.1590/S0034-8910.2015049006219
- Martins HA de Lima, 2016, J NEUROINFECTIOUS DI, V7
- Economopoulou A, 2009, EPIDEMIOL INFECT, V137, P534, DOI 10.1017/S0950268808001167
- Gasperina DD, 2015, TRANSPL INFECT DIS, V17, P876, DOI 10.1111/tid.12453
- Javelle E, 2015, PLOS NEGLECT TROP D, V9, DOI 10.1371/journal.pntd.0003603
- Johnson BW, 2016, J INFECT DIS, V214, pS471, DOI 10.1093/infdis/jiw274
- Kee ACL, 2010, EMERG INFECT DIS, V16, P1038, DOI 10.3201/eid1606.091115
- Lanciotti RS, 2007, EMERG INFECT DIS, V13, P764
- Lemant J, 2008, CRIT CARE MED, V36, P2536, DOI 10.1097/CCM.0b013e318183f2d2
- Petersen LR, 2016, F1000RES
- Pialoux G, 2007, LANCET INFECT DIS, V7, P319, DOI 10.1016/S1473-3099(07)70107-X
- Schilte C, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002137
- Simon F, 2015, MED MALADIES INFECT, V45, P243, DOI 10.1016/j.medmal.2015.05.007
- Staples JE, 2009, CLIN INFECT DIS, V49, P942, DOI 10.1086/605496
- Weaver SC, 2015, NEW ENGL J MED, V372, P1231, DOI 10.1056/NEJMra1406035