Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | CAVALCANTE, Rafael | |
dc.contributor.author | SOTOMI, Yohei | |
dc.contributor.author | LEE, Cheol W. | |
dc.contributor.author | AHN, Jung-Min | |
dc.contributor.author | FAROOQ, Vasim | |
dc.contributor.author | TATEISHI, Hiroki | |
dc.contributor.author | TENEKECIOGLU, Erhan | |
dc.contributor.author | ZENG, Yaping | |
dc.contributor.author | SUWANNASOM, Pannipa | |
dc.contributor.author | COLLET, Carlos | |
dc.contributor.author | ALBUQUERQUE, Felipe N. | |
dc.contributor.author | ONUMA, Yoshinobu | |
dc.contributor.author | PARK, Seung-Jung | |
dc.contributor.author | SERRUYS, Patrick W. | |
dc.date.accessioned | 2016-10-17T16:44:29Z | |
dc.date.available | 2016-10-17T16:44:29Z | |
dc.date.issued | 2016 | |
dc.description.abstract | BACKGROUND Currently available randomized data on the comparison between percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) for the treatment of unprotected left main coronary disease (LMD) lacks statistical power due to low numbers of patients enrolled. OBJECTIVES This study assessed long-term outcomes of PCI and CABG for the treatment of LMD in specific subgroups according to disease anatomic complexity. METHODS We conducted a pooled analysis of individual patient-level data of the LMD patients included in the PRECOMBAT (Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease) and SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) trials. Incidences of major adverse cardiac events were assessed at 5 years follow-up. RESULTS Study population comprised 1,305 patients. The incidence of major adverse cardiac and cerebrovascular events at 5 years was 28.3% in the PCI group and 23.0% in the CABG group (hazard ratio [HR]: 1.23; 95% confidence interval [CI]: 1.01 to 1.55; p = 0.045). This difference is mainly driven by a higher rate of repeat revascularization associated with PCI (HR: 1.85; 95% CI: 1.38 to 2.47; p < 0.001). The 2 strategies showed similar rates of the safety composite endpoint of death, myocardial infarction, or stroke (p = 0.45). In patients with isolated LM or LM + 1-vessel disease, PCI was associated with a 60% reduction in all-cause mortality (HR: 0.40; 95% CI: 0.20 to 0.83; p = 0.029) and 67% reduction in cardiac mortality (HR: 0.33; 95% CI: 0.12 to 0.88; p = 0.025) when compared with CABG. CONCLUSIONS In patients with unprotected LMD, CABG, and PCI result in similar rates of the safety composite endpoint of death, myocardial infarction, or stroke. In patients with isolated LM or LM _ 1-vessel disease, PCI is associated with lower all-cause and cardiac mortality when compared to CABG. (C) 2016 by the American College of Cardiology Foundation. | |
dc.description.index | MEDLINE | |
dc.identifier.citation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v.68, n.10, p.999-1009, 2016 | |
dc.identifier.doi | 10.1016/j.jacc.2016.06.024 | |
dc.identifier.eissn | 1558-3597 | |
dc.identifier.issn | 0735-1097 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/16453 | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER SCIENCE INC | |
dc.relation.ispartof | Journal of the American College of Cardiology | |
dc.rights | restrictedAccess | |
dc.rights.holder | Copyright ELSEVIER SCIENCE INC | |
dc.subject | coronary artery bypass graft surgery | |
dc.subject | left main coronary artery disease | |
dc.subject | long-term outcomes | |
dc.subject | percutaneous coronary intervention | |
dc.subject | randomized controlled trials | |
dc.subject.other | syntax score ii | |
dc.subject.other | eluting stent implantation | |
dc.subject.other | artery-disease | |
dc.subject.other | 5-year outcomes | |
dc.subject.other | randomized-trials | |
dc.subject.other | registry | |
dc.subject.other | revascularization | |
dc.subject.other | metaanalysis | |
dc.subject.other | graft | |
dc.subject.other | angioplasty | |
dc.subject.wos | Cardiac & Cardiovascular Systems | |
dc.title | Outcomes After Percutaneous Coronary Intervention or Bypass Surgery in Patients With Unprotected Left Main Disease | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.affiliation.country | Inglaterra | |
hcfmusp.affiliation.country | Coréia do Sul | |
hcfmusp.affiliation.country | Holanda | |
hcfmusp.affiliation.countryiso | nl | |
hcfmusp.affiliation.countryiso | kr | |
hcfmusp.affiliation.countryiso | gb | |
hcfmusp.author.external | SOTOMI, Yohei:Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands | |
hcfmusp.author.external | LEE, Cheol W.:Univ Ulsan, Coll Med, Asan Med Ctr, Inst Heart, Seoul, South Korea | |
hcfmusp.author.external | AHN, Jung-Min:Univ Ulsan, Coll Med, Asan Med Ctr, Inst Heart, Seoul, South Korea | |
hcfmusp.author.external | FAROOQ, Vasim:Cent Manchester Univ Hosp NHS Trust, Manchester Royal Infirm, Manchester Heart Ctr, Manchester, Lancs, England | |
hcfmusp.author.external | TATEISHI, Hiroki:Erasmus Univ, Med Ctr, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | TENEKECIOGLU, Erhan:Erasmus Univ, Med Ctr, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | ZENG, Yaping:Erasmus Univ, Med Ctr, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | SUWANNASOM, Pannipa:Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands | |
hcfmusp.author.external | COLLET, Carlos:Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands | |
hcfmusp.author.external | ALBUQUERQUE, Felipe N.:Erasmus Univ, Med Ctr, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | ONUMA, Yoshinobu:Erasmus Univ, Med Ctr, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands | |
hcfmusp.author.external | PARK, Seung-Jung:Univ Ulsan, Coll Med, Asan Med Ctr, Inst Heart, Seoul, South Korea | |
hcfmusp.author.external | SERRUYS, Patrick W.:Imperial Coll London, Int Ctr Circulatory Hlth, London, England | |
hcfmusp.citation.scopus | 95 | |
hcfmusp.contributor.author-fmusphc | RAFAEL CAVALCANTE E SILVA | |
hcfmusp.description.beginpage | 999 | |
hcfmusp.description.endpage | 1009 | |
hcfmusp.description.issue | 10 | |
hcfmusp.description.volume | 68 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.scopus | 2-s2.0-84993949415 | |
hcfmusp.origem.wos | WOS:000382313500003 | |
hcfmusp.publisher.city | NEW YORK | |
hcfmusp.publisher.country | USA | |
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hcfmusp.scopus.lastupdate | 2024-05-17 | |
relation.isAuthorOfPublication | 484753c2-e3ef-4da2-9dfd-9e59d441ff72 | |
relation.isAuthorOfPublication.latestForDiscovery | 484753c2-e3ef-4da2-9dfd-9e59d441ff72 |
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