Leprosy As a Complex infection: Breakdown of the Th1 and Th2 immune Paradigm in the immunopathogenesis of the Disease

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art_SOUSA_Leprosy_As_a_Complex_infection_Breakdown_of_the_2017.PDF (921.65 KB)
Citações na Scopus
59
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
SOUSA, Jorge Rodrigues de
QUARESMA, Juarez Antonio Simoes
Citação
FRONTIERS IN IMMUNOLOGY, v.8, article ID 1635, 8p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Leprosy is a chronic infectious disease whose evolution involves complex immune mechanisms of the host that influence the clinical presentation of the disease. For many years, the main interpretation of the host defense response was based on characterization of the established immune paradigm between T helper (Th) 1 and Th2 lymphocytes. However, with advances in the knowledge of immunology, new approaches have emerged along with the development of new immunological pathways that have changed the interpretation of the long-established paradigm of the polar forms of the disease, especially with the identification of new subtypes of T lymphocytes such as Th9, Th17, Th22, and Tregs. Thus, this review discusses the role of these new subtypes of T helper lymphocytes and how the development of the immune response of these cells modifies the pattern of the Th1/Th2 response in the immunopathogenesis of leprosy.
Palavras-chave
Mycobacterium leprae, immunology, cytokines, lymphocytes, immunopathology
URI
https://observatorio.fm.usp.br/handle/OPI/25555
Referências
  1. Ab B K, 1990, Eur J Immunol, V20, P369, DOI 10.1002/eji.1830200221
  2. Abdallah M, 2014, EXP DERMATOL, V23, P742, DOI 10.1111/exd.12529
  3. Amedei A, 2014, INTERN EMERG MED, V9, P303, DOI 10.1007/s11739-012-0867-9
  4. Antonio JR, 2013, AN BRAS DERMATOL, V88, P23, DOI 10.1590/abd1806-4841.20132187
  5. Attia EAS, 2014, ARCH DERMATOL RES, V306, P793, DOI 10.1007/s00403-014-1486-2
  6. Bobosha K, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0002773
  7. Bochud PY, 2003, J IMMUNOL, V170, P3451, DOI 10.4049/jimmunol.170.7.3451
  8. Bories GFP, 2017, FEBS LETT, V591, P3042, DOI 10.1002/1873-3468.12786
  9. Britton WJ, 2004, LANCET, V363, P1209, DOI 10.1016/S0140-6736(04)15952-7
  10. Chang HC, 2010, NAT IMMUNOL, V11, P527, DOI 10.1038/ni.1867
  11. Lira MLD, 2015, AM J DERMATOPATH, V37, P269
  12. De Freitas MRG, 2013, HAND CLINIC, V115, P499, DOI 10.1016/B978-0-444-52902-2.00028-X
  13. de Oliveira AL, 2013, IMMUNOLOGY, V140, P47, DOI 10.1111/imm.12108
  14. Aardo TLD, 2016, MICROB PATHOGENESIS, V90, P64, DOI 10.1016/j.micpath.2015.11.019
  15. de Sousa JR, 2017, J CLIN PATHOL, V70, P521, DOI 10.1136/jclinpath-2016-204110
  16. de Sousa JR, 2017, ACTA TROP, V171, P74, DOI 10.1016/j.actatropica.2017.03.016
  17. Aarao TLD, 2014, MICROB PATHOGENESIS, V77, P66, DOI 10.1016/j.micpath.2014.10.005
  18. Duhen T, 2009, NAT IMMUNOL, V10, P857, DOI 10.1038/ni.1767
  19. Edholm Eva-Stina, 2017, Results Probl Cell Differ, V62, P3, DOI 10.1007/978-3-319-54090-0_1
  20. Eyerich S, 2009, J CLIN INVEST, V119, P3573, DOI 10.1172/JCI40202
  21. Fabriek BO, 2009, BLOOD, V113, P887, DOI 10.1182/blood-2008-07-167064
  22. Fallows D, 2016, J INFLAMM-LOND, V13, DOI 10.1186/s12950-016-0117-4
  23. Finiasz MR, 2007, CLIN EXP IMMUNOL, V147, P139, DOI 10.1111/j.1365-2249.2006.03241.x
  24. Fischer MK, 2012, J DRUGS DERMATOL, V11, P1233
  25. Fulco TD, 2014, INFECT IMMUN, V82, P3968, DOI 10.1128/IAI.02194-14
  26. Furuzawa-Carballeda J, 2014, TRANSPL IMMUNOL, V30, P107, DOI 10.1016/j.trim.2014.02.002
  27. Rojas-Zuleta WG, 2016, AUTOIMMUN REV, V15, P649, DOI 10.1016/j.autrev.2016.02.020
  28. [Anonymous], 2015, Wkly Epidemiol Rec, V91, P405
  29. Golubovskaya V, 2016, CANCERS, V8, DOI 10.3390/cancers8030036
  30. Gonçalves Aguinaldo, 2013, Rev. bras. epidemiol., V16, P611, DOI 10.1590/S1415-790X2013000300006
  31. Hall Amy, 2011, Immunotherapy, V3, P719, DOI 10.2217/imt.11.58
  32. Hanington PC, 2007, DEV COMP IMMUNOL, V31, P817, DOI 10.1016/j.dci.2006.12.001
  33. Hedl M, 2014, P NATL ACAD SCI USA, V111, P13451, DOI 10.1073/pnas.1404178111
  34. Hesketh M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18071545
  35. Hirai KE, 2016, MICROB PATHOGENESIS, V91, P18, DOI 10.1016/j.micpath.2015.11.013
  36. Ismail N, 1999, J IMMUNOL, V163, P4842
  37. Iyer AM, 2007, HUM PATHOL, V38, P1065, DOI 10.1016/j.humpath.2006.12.017
  38. Kanazawa M, 2017, INT J MOL SCI, V18, DOI 10.3390/ijms18102135
  39. KAPLAN G, 1993, J INFECT DIS, V167, pS18, DOI 10.1093/infdis/167.Supplement_1.S18
  40. Kaplan MH, 2015, NAT REV IMMUNOL, V15, P295, DOI 10.1038/nri3824
  41. Kong Q, 2012, VIROL J, V9, DOI 10.1186/1743-422X-9-232
  42. Kumar S, 2013, IMMUNOBIOLOGY, V218, P1488, DOI 10.1016/j.imbio.2013.05.004
  43. Kumar S, 2013, MOL IMMUNOL, V56, P513, DOI 10.1016/j.molimm.2013.04.015
  44. Lastoria JC, 2012, DIAGN TRAT, V17, P173
  45. Lastoria JC, 2014, AN BRAS DERMATOL, V89, P389, DOI 10.1590/abd1806-4841.20142460
  46. Lockwood DNJ, 2011, PLOS NEGLECT TROP D, V5, DOI 10.1371/journal.pntd.0001327
  47. Magombedze G, 2013, FRONT PHYSIOL, V4, DOI 10.3389/fphys.2013.00206
  48. Marques CD, 2013, J INFECT DIS, V208, P120, DOI 10.1093/infdis/jit133
  49. Martiniuk F, 2012, J DRUGS DERMATOL, V11, P626
  50. Massone C, 2011, BRIT J DERMATOL, V165, P321, DOI 10.1111/j.1365-2133.2011.10412.x
  51. Mege JL, 2011, CURR OPIN INFECT DIS, V24, P230, DOI 10.1097/QCO.0b013e328344b73e
  52. Michalak-Stoma A, 2013, DIS MARKERS, DOI 10.1155/2013/856056
  53. Mignane BK, 2014, FRONT IMMUNOL, V5, P500, DOI [10.3389/fimmu.2014.00500, DOI 10.3389/FIMMU.2014.00500]
  54. MODLIN RL, 1994, J INVEST DERMATOL, V102, P828, DOI 10.1111/1523-1747.ep12381958
  55. Modlin RL, 2010, CURR OPIN IMMUNOL, V22, P48, DOI 10.1016/j.coi.2009.12.001
  56. Mohanraj A, 2014, J CLIN DIAGN RES, V8, P38, DOI 10.7860/JCDR/2014/6436.4100
  57. Montoya-Buelna M, 2013, BIOMED RES INT, DOI 10.1155/2013/459169
  58. Moura DF, 2012, EUR J IMMUNOL, V42, P2925, DOI 10.1002/eji.201142198
  59. Nascimento OJM, 2013, ARQ NEURO-PSIQUIAT, V71, P661, DOI 10.1590/0004-282X20130146
  60. Nath I, 2000, IMMUNOL LETT, V75, P69, DOI 10.1016/S0165-2478(00)00271-6
  61. Nath I, 2015, CLIN DERMATOL, V33, P90, DOI [10.1016/j.clindermato1.2014.07.005, 10.1016/j.clindermatol.2014.07.005]
  62. Nsagha Dickson Shey, 2011, Pan Afr Med J, V9, P4
  63. Ogawa R, 2013, J CELL MOL MED, V17, P817, DOI 10.1111/jcmm.12060
  64. Pal Sandip, 2012, J Indian Med Assoc, V110, P627
  65. PARIDA SK, 1992, CLIN IMMUNOL IMMUNOP, V63, P23, DOI 10.1016/0090-1229(92)90088-6
  66. Polycarpou A, 2013, CURR OPIN INFECT DIS, V26, P413, DOI 10.1097/QCO.0b013e3283638b04
  67. Pontillo A, 2013, INFECT GENET EVOL, V19, P274, DOI 10.1016/j.meegid.2013.06.006
  68. Rendini T, 2015, J ALLERGY CLIN IMMUN, V136, P1707, DOI 10.1016/j.jaci.2015.08.029
  69. Ridley D S, 1966, Int J Lepr Other Mycobact Dis, V34, P255
  70. Romero-Montoya M, 2017, PLOS NEGLECT TROP D, V11, DOI 10.1371/journal.pntd.0005325
  71. Sadhu S, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004338
  72. Saini C, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004592
  73. Saini C, 2014, PLOS NEGLECT TROP D, V8, DOI 10.1371/journal.pntd.0002639
  74. Saini C, 2013, PLOS NEGLECT TROP D, V7, DOI 10.1371/journal.pntd.0002338
  75. SANTOS DO, 2007, CURR IMMUNOL REV, V3, P77
  76. Saradna A, 2017, TRANSL RES, DOI [10.1016/j.trsl.2017.09.002, DOI 10.1016/J.TRSL.2017.09.002]
  77. Scollard DM, 2015, DERMATOL CLIN, V33, P541, DOI 10.1016/j.det.2015.03.016
  78. Silveira ED, 2015, J AM ACAD DERMATOL, V72, P729, DOI 10.1016/j.jaad.2014.11.023
  79. Quaresma JAS, 2014, MICROB PATHOGENESIS, V76, P84, DOI 10.1016/j.micpath.2014.07.005
  80. Quaresma JAS, 2012, MICROBES INFECT, V14, P696, DOI 10.1016/j.micinf.2012.02.010
  81. Sinsimer D, 2010, INFECT IMMUN, V78, P293, DOI 10.1128/IAI.00816-09
  82. Sousa JR, 2016, ACTA TROP, V157, P108, DOI [10.1016/j.actatropica.2016.01.008, DOI 10.1016/J.ACTATROPICA.2016.01.008]
  83. Souza Cacilda Silva, 1997, Medicina (Ribeirao Preto), V30, P325
  84. Spellberg B, 2001, CLIN INFECT DIS, V32, P76, DOI 10.1086/317537
  85. Suryadevara NC, 2013, HUM IMMUNOL, V74, P1034, DOI 10.1016/j.humimm.2013.04.009
  86. Tarique M, 2017, MOL IMMUNOL, V83, P72, DOI 10.1016/j.molimm.2017.01.008
  87. Parente JNT, 2015, AN BRAS DERMATOL, V90, P41, DOI 10.1590/abd1806-4841.20153311
  88. Truman RW, 2011, NEW ENGL J MED, V364, P1626, DOI 10.1056/NEJMoa1010536
  89. Fachin LRV, 2017, HISTOL HISTOPATHOL, V32, P385, DOI 10.14670/HH-11-804
  90. Virmond M, 2015, CLIN DERMATOL, V33, P8, DOI 10.1016/j.clindermatol.2014.07.006
  91. Giacoia-Gripp CBW, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0028735
  92. Walker SL, 2006, BRIT MED BULL, V77-78, P103, DOI 10.1093/bmb/ldl010
  93. Wang HS, 2013, BMC INFECT DIS, V13, DOI 10.1186/1471-2334-13-279
  94. Wang Y, 2017, INT IMMUNOPHARMACOL, V50, P345, DOI 10.1016/j.intimp.2017.07.019
  95. [Anonymous], 2017, Wkly Epidemiol Rec, V92, P501
  96. WHO, 2015, WKLY EPIDEMIOL REC, V90, P461
  97. YAMAMURA M, 1991, SCIENCE, V254, P277, DOI 10.1126/science.1925582
  98. Zhang F, 2014, MUCOSAL IMMUNOL, V7, P521, DOI 10.1038/mi.2013.69
  99. Zhou WS, 2003, J IMMUNOL, V170, P735, DOI 10.4049/jimmunol.170.2.735
  100. Ziakas PD, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0081047
  101. [Anonymous], 2014, WEEKLY EPIDEMIOLOGIC, V89, P389

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDT
Artigos e Materiais de Revistas Científicas - LIM/53
Artigos e Materiais de Revistas Científicas - ODS/03