PENILE AND SCROTUM SWELLING IN JUVENILE DERMATOMYOSITIS

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Arquivos
art_SALLUM_PENILE_AND_SCROTUM_SWELLING_IN_JUVENILE_DERMATOMYOSITIS_2011.PDF (114.66 KB)
Citações na Scopus
10
Tipo de produção
article
Data de publicação
2011
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
MEDFARMA-EDICOES MEDICAS, LDA
Autores
MICHELIN, Cintia Maria
Citação
ACTA REUMATOLOGICA PORTUGUESA, v.36, n.2, p.176-179, 2011
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Edema is a well-known feature of juvenile dermatomyositis (JDM). However, to our knowledge localized penile and scrotum swelling was not previously reported. During a 27-year period, 5,506 patients were followed up at the Pediatric Rheumatology Unit of our University Hospital and 157 patients (2.9%) had JDM. One of them (0.6%) had concomitant localized penile and scrotum swelling. He had severe disease activity since he was 7-year-old, manifested by diffuse cutaneous vasculitis, recurrent localized edema (limbs or face) and only one episode of generalized edema. At the age of 10, he presented edema of the genitalia associated with mild skin erythema. Penis, scrotum and testicular ultrasound as well as magnetic resonance imaging showed skin edema without testicular involvement. He was taking prednisone, methotrexate, cyclosporin, hydroxychloroquine and thalidomide. Improvement of skin rash, penile and scrotum swelling was noticed only with rituximab therapy. No adverse event was observed during anti-CD20 infusions and after six months of follow up. Penile and scrotum edema was a rare manifestation of JDM which improved with anti-CD20 monoclonal antibody treatment.
Palavras-chave
Juvenile Dermatomyositis, Rituximab, Penis, Scrotum, Edema
URI
https://observatorio.fm.usp.br/handle/OPI/23810
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Coleções
Artigos e Materiais de Revistas Científicas - HC/ICr
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/36
Artigos e Materiais de Revistas Científicas - LIM/44
Artigos e Materiais de Revistas Científicas - LIM/55