European ancestry and polymorphisms in DNA repair genes modify the risk of melanoma: A case-control study in a high UV index region in Brazil

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGONCALVES, Fernanda T.
dc.contributor.authorFRANCISCO, Guilherme
dc.contributor.authorSOUZA, Sonia P. de
dc.contributor.authorLUIZ, Olinda C.
dc.contributor.authorFESTA-NETO, Cyro
dc.contributor.authorSANCHES, Jose A.
dc.contributor.authorCHAMMAS, Roger
dc.contributor.authorGATTAS, Gilka J. F.
dc.contributor.authorELUF-NETO, Jose
dc.date.accessioned2017-11-27T16:26:19Z
dc.date.available2017-11-27T16:26:19Z
dc.date.issued2011
dc.description.abstractBackground: UV radiation is the major environmental factor related to development of cutaneous melanoma. Besides sun exposure and the influence of latitude, some host characteristics such as skin phototype and hair and eye color are also risk factors for melanoma. Polymorphisms in DNA repair genes could be good candidates for susceptibility genes, mainly in geographical regions exposed to high solar radiation. Objective: Evaluate the role of host characteristic.; and DNA repair polymorphism in melanoma risk in Brazil. Methods: We carried out a hospital-based case-control study in Brazil to evaluate the contribution of host factors and polymorphisms in DNA repair to melanoma risk. A total of 412 patients (202 with melanoma and 210 controls) were analyzed regarding host characteristics for melanoma risk as well as for 11 polymorphisms in DNA repair genes. Results: We found an association of host characteristics with melanoma development, such as eye and hair color, fair skin, history of pigmented lesions removed, sunburns in childhood and adolescence, and also European ancestry. Regarding DNA repair gene polymorphisms, we found protection for the XPG 1104 His/His genotype (OR 0.32; 95% CI 0.13-0.75), and increased risk for three polymorphisms in the XPC gene (PAT+; IV-6A and 939Gln), which represent a haplotype for XPC. Melanoma risk was higher in individuals carrying the complete XPC haplotype than each individual polymorphism (OR 3.64; 95% CI 1.77-7.48). Conclusions: Our data indicate that the host factors European ancestry and XPC polymorphisms contributed to melanoma risk in a region exposed to high sun radiation.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [06-52041-9, 05-56069-2]
dc.description.sponsorshipCNPq [478239/03-3]
dc.description.sponsorshipCNPq-Brazil
dc.identifier.citationJOURNAL OF DERMATOLOGICAL SCIENCE, v.64, n.1, p.59-66, 2011
dc.identifier.doi10.1016/j.jdermsci.2011.06.003
dc.identifier.issn0923-1811
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22949
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofJournal of Dermatological Science
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER IRELAND LTD
dc.subjectMelanoma
dc.subjectCase-control
dc.subjectDNA repair gene polymorphisms
dc.subjectXPC
dc.subjectNucleotide excision repair
dc.subject.othernucleotide excision-repair
dc.subject.othercutaneous melanoma
dc.subject.otherultraviolet-radiation
dc.subject.othersouthern brazil
dc.subject.othersun exposure
dc.subject.otherskin-cancer
dc.subject.otherxpd
dc.subject.otherassociation
dc.subject.otherdamage
dc.subject.otherpredisposition
dc.subject.wosDermatology
dc.titleEuropean ancestry and polymorphisms in DNA repair genes modify the risk of melanoma: A case-control study in a high UV index region in Brazil
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSOUZA, Sonia P. de:Univ Sao Paulo, Fac Med, Dept Prevent Med, Lab Epidemiol Imunobiol LIM38, BR-01246903 Sao Paulo, Brazil
hcfmusp.citation.scopus32
hcfmusp.contributor.author-fmusphcFERNANDA DE TOLEDO GONCALVES
hcfmusp.contributor.author-fmusphcGUILHERME FRANCISCO
hcfmusp.contributor.author-fmusphcOLINDA DO CARMO LUIZ
hcfmusp.contributor.author-fmusphcCYRO FESTA NETO
hcfmusp.contributor.author-fmusphcJOSE ANTONIO SANCHES JUNIOR
hcfmusp.contributor.author-fmusphcROGER CHAMMAS
hcfmusp.contributor.author-fmusphcGILKA JORGE FIGARO GATTAS
hcfmusp.contributor.author-fmusphcJOSE ELUF NETO
hcfmusp.description.beginpage59
hcfmusp.description.endpage66
hcfmusp.description.issue1
hcfmusp.description.volume64
hcfmusp.origemWOS
hcfmusp.origem.pubmed21733660
hcfmusp.origem.scopus2-s2.0-80052375957
hcfmusp.origem.wosWOS:000295192400009
hcfmusp.publisher.cityCLARE
hcfmusp.publisher.countryIRELAND
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