Characterization of oncogene suppressor marker expression in patients with submucosal gastric carcinoma

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMORON, Roberson A.
dc.contributor.authorJACOB, Carlos Eduardo
dc.contributor.authorBRESCIANI, Claudio Jose Caldas
dc.contributor.authorSIMOES, Kleber
dc.contributor.authorALVES, Venancio Avancini Ferreira
dc.contributor.authorIRYA, Kyoshi
dc.contributor.authorGAMA-RODRIGUES, Joaquim
dc.contributor.authorCECCONELLO, Ivan
dc.contributor.authorLONGATTO-FILHO, Adhemar
dc.contributor.authorZILBERSTEIN, Bruno
dc.date.accessioned2019-02-21T17:24:15Z
dc.date.available2019-02-21T17:24:15Z
dc.date.issued2018
dc.description.abstractThe aim of the present study was to determine the clinical significance of p53 and p21(ras) p21(wafl), p27(kip1) and p16(ink4a) expression in cases of early gastric cancer. A total of 81 patients who had undergone gastrectomy with D2 lymphadenectomy between 1971 and 2004 were retrospectively investigated. The immunohistochemical expression of p21ras, p53, p21waf1.cip1, p27kip1 and p16ink4a in the tissues was evaluated. In normal, metaplastic and tumoral mucosa, p53 was positive in 53, 87.3, and 87.1% of the cases, respectively. In the same tissues, p21ras was positive in 85.3, 86 and 96.8%, respectively. Positivity for p16ink4a was detected in 46.3, 91.1 and 86% of the cases, respectively, whereas p27kip1 was positive in 60, 94.7 and 95.3%, and p21wafl/ cip1 was positive in 32.4, 72.7 and 71.4% of the cases, respectively. All the tumors were positive for p53. Tumors with lymph node invasion presented with overexpression (+ 4) of p53 in 47% of the cases vs. 17% of patients who did not have lymph node involvement. Therefore, higher expression of p53, p21ras and p21wafl/ cip1 in the tumor exhibited a statistically significant association with lymph node involvement.eng
dc.description.indexPubMedeng
dc.identifier.citationMOLECULAR AND CLINICAL ONCOLOGY, v.8, n.3, p.477-482, 2018
dc.identifier.doi10.3892/mco.2017.1545
dc.identifier.eissn2049-9469
dc.identifier.issn2049-9450
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/30852
dc.language.isoeng
dc.publisherSPANDIDOS PUBL LTDeng
dc.relation.ispartofMolecular and Clinical Oncology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright SPANDIDOS PUBL LTDeng
dc.subjectgastric cancereng
dc.subjectp21(ras)eng
dc.subjectp53eng
dc.subjectp21(waf1/cip1)eng
dc.subjectp27(kip1)eng
dc.subjectp16(ink4a)eng
dc.subject.otherlymph-node metastasiseng
dc.subject.otherp21(waf1/cip1) expressioneng
dc.subject.otherhelicobacter-pylorieng
dc.subject.otherprotein expressioneng
dc.subject.otherprognostic-significanceeng
dc.subject.otherproliferative activityeng
dc.subject.otherdisease progressioneng
dc.subject.othere-cadherineng
dc.subject.otherp53eng
dc.subject.othercancereng
dc.subject.wosOncologyeng
dc.titleCharacterization of oncogene suppressor marker expression in patients with submucosal gastric carcinomaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMORON, Roberson A.:Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-14784400 Sao Paulo, SP, Brazil
hcfmusp.author.externalSIMOES, Kleber:Univ Sao Paulo, Sch Med, Dept Pathol, BR-14784400 Sao Paulo, SP, Brazil
hcfmusp.contributor.author-fmusphcCARLOS EDUARDO JACOB
hcfmusp.contributor.author-fmusphcCLAUDIO JOSE CALDAS BRESCIANI
hcfmusp.contributor.author-fmusphcVENANCIO AVANCINI FERREIRA ALVES
hcfmusp.contributor.author-fmusphcKIYOSHI IRIYA
hcfmusp.contributor.author-fmusphcJOAQUIM JOSE GAMA RODRIGUES
hcfmusp.contributor.author-fmusphcIVAN CECCONELLO
hcfmusp.contributor.author-fmusphcADHEMAR LONGATTO FILHO
hcfmusp.contributor.author-fmusphcBRUNO ZILBERSTEIN
hcfmusp.description.beginpage477
hcfmusp.description.endpage482
hcfmusp.description.issue3
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.pubmed29468062
hcfmusp.origem.wosWOS:000456299400018
hcfmusp.publisher.cityATHENSeng
hcfmusp.publisher.countryGREECEeng
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