Obstructive sleep apnoea is associated with myocardial injury in patients with refractory angina

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorGEOVANINI, Glaucylara R.
dc.contributor.authorPEREIRA, Alexandre C.
dc.contributor.authorGOWDAK, Luis H. W.
dc.contributor.authorDOURADO, Luciana Oliveira Cascaes
dc.contributor.authorPOPPI, Nilson T.
dc.contributor.authorVENTURINI, Gabriela
dc.contributor.authorDRAGER, Luciano F.
dc.contributor.authorLORENZI-FILHO, Geraldo
dc.date.accessioned2016-10-17T16:35:40Z
dc.date.available2016-10-17T16:35:40Z
dc.date.issued2016
dc.description.abstractObjective To investigate the association between obstructive sleep apnoea (OSA) severity with markers of overnight myocardial injury in patients with refractory angina. Methods Patients with refractory angina were characterised clinically and they underwent ischaemia imaging stress tests by single-photon emission computed tomography (SPECT) and/or cardiac MRI. The patients were admitted to the hospital, remained under resting conditions for blood determination of high-sensitivity cardiac troponin T (hs-cTnT) at 14:00, 22:00 and after overnight polysomnography at 7:00. Results We studied 80 consecutive patients (age: 62 +/- 10 years; male: 66%; body mass index (BMI): 29.5 +/- 4 kg/m(2)) with well-established diagnosis of refractory angina. The mean apnoea-hypopnoea index (AHI) was 37 +/- 29 events/h and OSA (AHI >15 events/h) was present in 75% of the population. Morning detectable hs-cTnT and above 99th percentile was present in 88% and 36% of the population, respectively. Patients in the first to third quartiles of OSA severity did not have circadian variation of hs-cTnT. In contrast, patients in the fourth quartile (AHI >= 51 events/h) had a circadian variation of hs-cTnT with a morning peak of hs-cTnT that was two times higher than that in the remaining population (p = 0.02). The highest quartile of OSA severity remained associated with the highest quartile of hs-cTnT (p = 0.028) in multivariate analysis. Conclusion Very severe OSA is common and independently associated with overnight myocardial injury in patients with refractory angina.
dc.description.indexMEDLINE
dc.identifier.citationHEART, v.102, n.15, p.1193-0, 2016
dc.identifier.doi10.1136/heartjnl-2015-309009
dc.identifier.eissn1468-201X
dc.identifier.issn1355-6037
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/16122
dc.language.isoeng
dc.publisherBMJ PUBLISHING GROUP
dc.relation.ispartofHeart
dc.rightsrestrictedAccess
dc.rights.holderCopyright BMJ PUBLISHING GROUP
dc.subject.othercoronary-artery-disease
dc.subject.othercardiac troponin-t
dc.subject.otherpositive airway pressure
dc.subject.othercomputed-tomography
dc.subject.otherrisk
dc.subject.otherhypertension
dc.subject.otheratherosclerosis
dc.subject.othercardiology
dc.subject.othercommunity
dc.subject.othercommon
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleObstructive sleep apnoea is associated with myocardial injury in patients with refractory angina
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcGLAUCYLARA REIS GEOVANINI
hcfmusp.contributor.author-fmusphcALEXANDRE DA COSTA PEREIRA
hcfmusp.contributor.author-fmusphcLUIS HENRIQUE WOLFF GOWDAK
hcfmusp.contributor.author-fmusphcLUCIANA OLIVEIRA CASCAES DOURADO
hcfmusp.contributor.author-fmusphcNILSON TAVARES POPPI
hcfmusp.contributor.author-fmusphcGABRIELA VENTURINI DA SILVA
hcfmusp.contributor.author-fmusphcLUCIANO FERREIRA DRAGER
hcfmusp.contributor.author-fmusphcGERALDO LORENZI FILHO
hcfmusp.description.beginpage1193
hcfmusp.description.endpage0
hcfmusp.description.issue15
hcfmusp.description.volume102
hcfmusp.origemWOS
hcfmusp.origem.pubmed27048771
hcfmusp.origem.scopus2-s2.0-84963959553
hcfmusp.origem.wosWOS:000380169700009
hcfmusp.publisher.cityLONDON
hcfmusp.publisher.countryENGLAND
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