Young-age onset colorectal cancer in Brazil: Analysis of incidence, clinical features, and outcomes in a tertiary cancer center

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art_SILVA_Youngage_onset_colorectal_cancer_in_Brazil_Analysis_of_2019.PDF (939.27 KB)
Citações na Scopus
14
Tipo de produção
article
Data de publicação
2019
DOI
Scopus
Web of Science
PubMed
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MOSBY-ELSEVIER
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Citação
CURRENT PROBLEMS IN CANCER, v.43, n.5, p.477-486, 2019
Projetos de Pesquisa
Unidades Organizacionais
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Resumo
Background: Recent studies report increasing incidence of colorectal cancer (CRC) in the young-age population, but data concerning clinical behavior, pathologic findings, and prognosis are controversial for this group. Early recognition of CRC in young patients is a challenge and diagnosis at advanced stage is clearly associated with worse outcomes. Materials and methods: We retrospectively reviewed medical records of 5806 patients diagnosed with CRC between January/2011 and November/2016 and identified 781 patients aged less than 50-years-old. Results: We found an absolute increasing in the incidence of CRC in patients <50 years old of 1.88%-2.23% annually, with a relative increasing of 35.3% between 2011 and 2016. Median age was 42 years, 57.4% were female and 20.9% reported family history of CRC. Left-sided tumors were more frequent and the majority of patients were symptomatic. The most common stages at diagnosis were III (34.1%) and IV (37.3%). The median overall survival (OS) for stage IV was 25 months (95% Cl 20.7-29.3) and was not reached for Stages I-III (P < 0.001). Family history of CRC was independently associated with better OS in stage IV(P= 0.02). For stages I-III, wild-type KRAS, family history of CRC, and absence of angiolymphatic invasion were associated with better OS (P.0.02, P=0.01 and P < 0.001, respectively). Conclusions: In our cohort, the incidence of early-onset CRC is increasing over the past years. Young patients were more likely to be diagnosed with metastatic disease, left-sided and/or rectum site and symptoms at presentation. These findings highlight the emerging importance of young-age onset CRC and the need to discuss strategies to early diagnosis.
Palavras-chave
Screening, Diagnosis, Early-onset, Epidemiology, Survival
URI
https://observatorio.fm.usp.br/handle/OPI/34374
Referências
  1. Ben-Aharon I, 2015, EUR J CANCER, V51, pS396, DOI 10.1016/S0959-8049(16)31108-X
  2. Betge J, 2012, CANCER-AM CANCER SOC, V118, P628, DOI 10.1002/cncr.26310
  3. Bibbins-Domingo K, 2016, JAMA-J AM MED ASSOC, V315, P2564, DOI 10.1001/jama.2016.5989
  4. Bisschop CNS, 2014, AM J CLIN NUTR, V99, P139, DOI 10.3945/ajcn.113.066530
  5. Bosetti C, 2011, EUR J CANCER PREV, V20, P355, DOI 10.1097/CEJ.0b013e32834653c9
  6. Chatenoud L, 2010, EUR J CANCER PREV, V19, P79, DOI 10.1097/CEJ.0b013e32833233be
  7. Connell LC, 2017, CURR TREAT OPTION ON, V18, DOI 10.1007/s11864-017-0463-3
  8. EDDY DM, 1990, ANN INTERN MED, V113, P373, DOI 10.7326/0003-4819-113-5-373
  9. Edwards BK, 2010, CANCER-AM CANCER SOC, V116, P544, DOI 10.1002/cncr.24760
  10. INCA - Instituto Nacional de Cancer, EST 2018 SINT RES CO
  11. ISBISTER WH, 1992, AUST NZ J SURG, V62, P468, DOI 10.1111/j.1445-2197.1992.tb07227.x
  12. Johnson CM, 2013, CANCER CAUSE CONTROL, V24, P1207, DOI 10.1007/s10552-013-0201-5
  13. Kansakar P, 2012, ASIAN PAC J CANCER P, V13, P3209, DOI 10.7314/APJCP.2012.13.7.3209
  14. Karahalios A, 2015, AM J EPIDEMIOL, V181, P832, DOI 10.1093/aje/kwu357
  15. Lee J, 2016, MEDICINE, V95, P4840
  16. Lim SB, 2010, DIS COLON RECTUM, V53, P377, DOI 10.1007/DCR.0b013e3181cf8ae5
  17. O'Connell JB, 2003, AM SURGEON, V69, P866
  18. Oosterlo P, 2018, J MAR SCI ENG, V6, DOI 10.3390/jmse6020048
  19. Perea J, 2014, J MOL DIAGN, V16, P116, DOI 10.1016/j.jmoldx.2013.07.010
  20. Popat S, 2005, J CLIN ONCOL, V23, P609, DOI 10.1200/JCO.2005.01.086
  21. Rahman R, 2015, CANCER MED-US, V4, P1863, DOI 10.1002/cam4.560
  22. Renehan AG, 2008, LANCET, V371, P569, DOI 10.1016/S0140-6736(08)60269-X
  23. Shin A, 2012, CANCER RES TREAT, V44, P219, DOI 10.4143/crt.2012.44.4.219
  24. Sia CS, 2014, COLORECTAL DIS, V16, P690, DOI 10.1111/codi.12648
  25. Siegel R, 2013, CA-CANCER J CLIN, V63, P11, DOI 10.3322/caac.21166
  26. Siegel RL, 2016, CA-CANCER J CLIN, V66, P7, DOI 10.3322/caac.21332
  27. Siegel RL, 2009, CANCER EPIDEM BIOMAR, V18, P1695, DOI 10.1158/1055-9965.EPI-09-0186
  28. Sinicrope FA, 2011, JNCI-J NATL CANCER I, V103, P863, DOI 10.1093/jnci/djr153
  29. Sinicrope FA, 2010, NAT REV CLIN ONCOL, V7, P174, DOI 10.1038/nrclinonc.2009.235
  30. Thune I, 1996, BRIT J CANCER, V73, P1134, DOI 10.1038/bjc.1996.218
  31. Torre LA, 2015, CA-CANCER J CLIN, V65, P87, DOI 10.3322/caac.21262
  32. Wolf AMD, 2018, CA-CANCER J CLIN, V68, P250, DOI 10.3322/caac.21457
  33. Yantiss RK, 2009, AM J SURG PATHOL, V33, P572, DOI 10.1097/PAS.0b013e31818afd6b
  34. Yee YK, 2010, J GASTROEN HEPATOL, V25, P923, DOI 10.1111/j.1440-1746.2009.06130.x
  35. You YN, 2012, ARCH INTERN MED, V172, P287, DOI 10.1001/archinternmed.2011.602
  36. Young JP, 2015, J GASTROEN HEPATOL, V30, P6, DOI 10.1111/jgh.12792
  37. Yuhara H, 2011, AM J GASTROENTEROL, V106, P1911, DOI 10.1038/ajg.2011.301

Coleções
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - ODS/03