Biologic Impact of Mechanical Power at High and Low Tidal Volumes in Experimental Mild Acute Respiratory Distress Syndrome
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | |
dc.contributor.author | SANTOS, Raquel S. | |
dc.contributor.author | MAIA, Ligia de A. | |
dc.contributor.author | OLIVEIRA, Milena V. | |
dc.contributor.author | SANTOS, Cintia L. | |
dc.contributor.author | MORAES, Lillian | |
dc.contributor.author | PINTO, Eliete F. | |
dc.contributor.author | SAMARY, Cynthia dos S. | |
dc.contributor.author | MACHADO, Joana A. | |
dc.contributor.author | CARVALHO, Anna Carolinna | |
dc.contributor.author | FERNANDES, Marcos Vinicius de S. | |
dc.contributor.author | MARTINS, Vanessa | |
dc.contributor.author | CAPELOZZI, Vera L. | |
dc.contributor.author | MORALES, Marcelo M. | |
dc.contributor.author | KOCH, Thea | |
dc.contributor.author | ABREU, Marcelo Gama de | |
dc.contributor.author | PELOSI, Paolo | |
dc.contributor.author | SILVA, Pedro L. | |
dc.contributor.author | ROCCO, Patricia R. M. | |
dc.date.accessioned | 2018-09-13T15:26:33Z | |
dc.date.available | 2018-09-13T15:26:33Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Background: The authors hypothesized that low tidal volume (V-T) would minimize ventilator-induced lung injury regardless of the degree of mechanical power. The authors investigated the impact of power, obtained by different combinations of V-T and respiratory rate (RR), on ventilator-induced lung injury in experimental mild acute respiratory distress syndrome (ARDS). Methods: Forty Wistar rats received Escherichia coli lipopolysaccharide intratracheally. After 24h, 32 rats were randomly assigned to be mechanically ventilated (2 h) with a combination of different V-T (6 ml/kg and 11 ml/kg) and RR that resulted in low and high power. Power was calculated as energy (Delta P,(2)(L)/E,(L)) x RR (Delta P,(L) = transpulmonary driving pressure; E,(L) = lung elastance), and was three-fold higher in high than in low power groups. Eight rats were not mechanically ventilated and used for molecular biology analysis. Results: Diffuse alveolar damage score, which represents the severity of edema, atelectasis, and overdistension, was increased in high V-T compared to low V-T, in both low (low V-T: 11 [9 to 14], high V-T: 18 [15 to 20]) and high (low V-T: 19 [16 to 25], high V-T: 29 [27 to 30]) power groups. At high V-T, interleukin-6 and amphiregulin expressions were higher in high-power than in low-power groups. At high power, amphiregulin and club cell protein 16 expressions were higher in high V-T than in low V-T. Mechanical energy and power correlated well with diffuse alveolar damage score and interleukin-6, amphiregulin, and club cell protein 16 expression. Conclusions: In experimental mild ARDS, even at low V-T, high mechanical power promoted ventilator-induced lung injury. To minimize ventilator-induced lung injury, low V-T should be combined with low power. | |
dc.description.index | MEDLINE | |
dc.description.sponsorship | Brazilian Council for Scientific and Technological Development (CNPq | |
dc.description.sponsorship | Brasilia, Brazil) | |
dc.description.sponsorship | Rio de Janeiro State Research Foundation (FAPERJ | |
dc.description.sponsorship | Rio de Janeiro, Brazil) | |
dc.description.sponsorship | Sao Paulo State Research Foundation (FAPESP | |
dc.description.sponsorship | Sao Paolo, Brazil) | |
dc.description.sponsorship | National Institute of Science and Technology for Regenerative Medicine (INCT-REGENERA | |
dc.description.sponsorship | Rio de Janeiro, Brazil) | |
dc.description.sponsorship | Coordination for the Improvement of Higher Education Personnel (CAPES | |
dc.description.sponsorship | Brasilia, Brazil) | |
dc.identifier.citation | ANESTHESIOLOGY, v.128, n.6, p.1193-1206, 2018 | |
dc.identifier.doi | 10.1097/ALN.0000000000002143 | |
dc.identifier.eissn | 1528-1175 | |
dc.identifier.issn | 0003-3022 | |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/28248 | |
dc.language.iso | eng | |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | |
dc.relation.ispartof | Anesthesiology | |
dc.rights | restrictedAccess | |
dc.rights.holder | Copyright LIPPINCOTT WILLIAMS & WILKINS | |
dc.subject.other | induced lung injury | |
dc.subject.other | end-expiratory pressure | |
dc.subject.other | driving pressure | |
dc.subject.other | ventilation | |
dc.subject.other | pulmonary | |
dc.subject.other | flow | |
dc.subject.other | inflammation | |
dc.subject.other | metaanalysis | |
dc.subject.other | hypercapnia | |
dc.subject.other | strategies | |
dc.subject.wos | Anesthesiology | |
dc.title | Biologic Impact of Mechanical Power at High and Low Tidal Volumes in Experimental Mild Acute Respiratory Distress Syndrome | |
dc.type | article | |
dc.type.category | original article | |
dc.type.version | publishedVersion | |
dspace.entity.type | Publication | |
hcfmusp.affiliation.country | Alemanha | |
hcfmusp.affiliation.country | Itália | |
hcfmusp.affiliation.countryiso | de | |
hcfmusp.affiliation.countryiso | it | |
hcfmusp.author.external | SANTOS, Raquel S.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | MAIA, Ligia de A.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | OLIVEIRA, Milena V.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | SANTOS, Cintia L.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | MORAES, Lillian:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | PINTO, Eliete F.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | SAMARY, Cynthia dos S.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | MACHADO, Joana A.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | CARVALHO, Anna Carolinna:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | FERNANDES, Marcos Vinicius de S.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | MORALES, Marcelo M.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Cellular & Mol Physiol, Rio De Janeiro, Brazil | |
hcfmusp.author.external | KOCH, Thea:Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Anesthesiol & Intens Care Therapy, Pulm Engn Grp, Dresden, Germany | |
hcfmusp.author.external | ABREU, Marcelo Gama de:Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Anesthesiol & Intens Care Therapy, Pulm Engn Grp, Dresden, Germany | |
hcfmusp.author.external | PELOSI, Paolo:Univ Genoa, Dept Surg Sci & Integrated Diagnost, San Martino Policlin Hosp, IRCCS Oncol, Genoa, Italy | |
hcfmusp.author.external | SILVA, Pedro L.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.author.external | ROCCO, Patricia R. M.:Univ Fed Rio de Janeiro, Carlos Chagas Filho Biophys Inst, Lab Pulm Invest, Rio De Janeiro, Brazil | |
hcfmusp.citation.scopus | 46 | |
hcfmusp.contributor.author-fmusphc | VANESSA MARTINS DA SILVA | |
hcfmusp.contributor.author-fmusphc | VERA LUIZA CAPELOZZI | |
hcfmusp.description.beginpage | 1193 | |
hcfmusp.description.endpage | 1206 | |
hcfmusp.description.issue | 6 | |
hcfmusp.description.volume | 128 | |
hcfmusp.origem | WOS | |
hcfmusp.origem.pubmed | 29489470 | |
hcfmusp.origem.scopus | 2-s2.0-85045996078 | |
hcfmusp.origem.wos | WOS:000441172900019 | |
hcfmusp.publisher.city | PHILADELPHIA | |
hcfmusp.publisher.country | USA | |
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hcfmusp.scopus.lastupdate | 2024-05-10 | |
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relation.isAuthorOfPublication | eabdbb85-f2d4-497a-a33c-81c972fe1a4b | |
relation.isAuthorOfPublication.latestForDiscovery | 54294614-876e-4765-8fc1-ff6ce6ea3e42 |
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