Importance of Stem Cell Transplantation in Cleft Lip and Palate Surgical Treatment Protocol

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMAZZETTI, Marcelo Paulo Vaccari
dc.contributor.authorALONSO, Nivaldo
dc.contributor.authorBROCK, Ryane Schmidt
dc.contributor.authorAYOUB, Alexandre
dc.contributor.authorMASSUMOTO, Sally Mizukami
dc.contributor.authorECA, Lilian Pinero
dc.date.accessioned2018-11-21T16:59:16Z
dc.date.available2018-11-21T16:59:16Z
dc.date.issued2018
dc.description.abstractCleft lip and palate is a congenital malformation that requires a multidisciplinary treatment that evolves pediatrician, obstetrics, fetal medicine, genetics, plastic surgery, orthodontics, speech therapist, nursery, and psychology. Actually, the authors believe that it could be possible to ad protocols to use stem cells. The intrauterine diagnosis leads to preborn parental orientation and better parental collaboration to accept a precocious multidisciplinary treatment. After birth the authors' protocol is: orthodontic devices, phonoaudiology, and surgical procedures. The authors' cleft lip and palate reconstructive surgery protocol demands several steps and begins at 4 to 6-month old with rhinocheiloplasty and soft palate closure at the same moment. The treatment sequence involves the hard palate surgery (8-18 months after the first surgical step), alveoloplasty (after 10 years old), and secondary rhinoplasty (after 14 years old). New ideas to use stern cells and blood from the umbilical cord and also blood from placenta are discussed to improve final surgical results. Maternal stem cells are easy to collect, there are no damage to the patient and mother, it is autologous and it could be very useful in the authors' protocol. Nine patients with clef lip and palate were operated and had stem cells from umbilical cord blood and placenta blood injected into the bone and soft tissue during the primary procedure (rhinocheiloplasty). The stem cells activity into soft tissue and hone were evaluated. Preliminary results have shown no adverse results and improvement at the inflammatory response. A treatment protocol with stem cells was developed. It had a long time follow-up of 10 years.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF CRANIOFACIAL SURGERY, v.29, n.6, p.1445-1451, 2018
dc.identifier.doi10.1097/SCS.0000000000004766
dc.identifier.eissn1536-3732
dc.identifier.issn1049-2275
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29328
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofJournal of Craniofacial Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectCleft lip
dc.subjectcleft palate
dc.subjectreconstructive surgery
dc.subjectstem cell
dc.subject.otherstromal cells
dc.subject.otherreconstruction
dc.subject.otherdefect
dc.subject.otherfat
dc.subject.wosSurgery
dc.titleImportance of Stem Cell Transplantation in Cleft Lip and Palate Surgical Treatment Protocol
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalMAZZETTI, Marcelo Paulo Vaccari:Darcy Vargas Children Hosp, Brazilian Plast Surg Soc, Brazilian Cleft Lip & Palate Soc, Plast Surg Div, Sao Paulo, Brazil
hcfmusp.author.externalBROCK, Ryane Schmidt:Darcy Vargas Children Hosp, Brazilian Plast Surg Soc, Plast Surg Div, Sao Paulo, Brazil
hcfmusp.author.externalAYOUB, Alexandre:Brazilian Cryogen Ctr, Sao Paulo, Brazil
hcfmusp.author.externalMASSUMOTO, Sally Mizukami:Brazilian Cryogen Ctr, Umbil Cord Blood Lab, Sao Paulo, Brazil
hcfmusp.author.externalECA, Lilian Pinero:Facial Defects Studies & Res Ctr, Sao Paulo, Brazil
hcfmusp.citation.scopus7
hcfmusp.contributor.author-fmusphcNIVALDO ALONSO
hcfmusp.description.beginpage1445
hcfmusp.description.endpage1451
hcfmusp.description.issue6
hcfmusp.description.volume29
hcfmusp.origemWOS
hcfmusp.origem.pubmed30067525
hcfmusp.origem.scopus2-s2.0-85055618111
hcfmusp.origem.wosWOS:000446583200061
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-17
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relation.isAuthorOfPublication.latestForDiscovery15477aea-4408-4b6d-8c22-510df29a2dce
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