The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex

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art_CASTRO-FONSECA_The_influence_of_age_and_sex_on_the_2023.PDF (1.69 MB)
Citações na Scopus
2
Tipo de produção
article
Data de publicação
2023
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
OXFORD UNIV PRESS INC
Autores
CASTRO-FONSECA, Emily
MORAIS, Viviane
SILVA, Camila G. da
WOLLNER, Juliana
FREITAS, Jaqueline
MELLO-NETO, Arthur F.
OLIVEIRA, Luiz E.
OLIVEIRA, Vilson C. de
Citação
CEREBRAL CORTEX, v.33, n.13, p.8654-8666, 2023
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
The human cerebral cortex is one of the most evolved regions of the brain, responsible for most higher-order neural functions. Since nerve cells (together with synapses) are the processing units underlying cortical physiology and morphology, we studied how the human neocortex is composed regarding the number of cells as a function of sex and age. We used the isotropic fractionator for cell quantification of immunocytochemically labeled nuclei from the cerebral cortex donated by 43 cognitively healthy subjects aged 25-87 years old. In addition to previously reported sexual dimorphism in the medial temporal lobe, we found more neurons in the occipital lobe of men, higher neuronal density in women's frontal lobe, but no sex differences in the number and density of cells in the other lobes and the whole neocortex. On average, the neocortex has similar to 10.2 billion neurons, 34% in the frontal lobe and the remaining 66% uniformly distributed among the other 3 lobes. Along typical aging, there is a loss of non-neuronal cells in the frontal lobe and the preservation of the number of neurons in the cortex. Our study made possible to determine the different degrees of modulation that sex and age evoke on cortical cellularity.
Palavras-chave
aging, cerebral cortex, isotropic fractionator, number of neurons, sexual dimorphism
URI
https://observatorio.fm.usp.br/handle/OPI/54564
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/15
Artigos e Materiais de Revistas Científicas - LIM/22
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